Method for ISS annotations
Phylogenetic Annotation (IBA)
UniProt-GOA annotation (ISO)
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Rhea-based UniProt to GO mapping
Automatic Gene Ontology annotation by MGI
Manual transfer of experimentally verified GO annotation data to orthologs by UniProt
UniProt-based electronic GO annotation (UniRule/ARBA/InterPro)
DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter.
The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.
Murine Sall1 represses transcription by recruiting a histone deacetylase complex.
Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
Class II histone deacetylases: versatile regulators.
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development.
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.
Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo.
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases.
Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation.
Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.
HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment.
Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.
REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.
The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
Mnt transcriptional repressor is functionally regulated during cell cycle progression.
Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation.
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity.
Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.
Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.
Adipose tissue mass is modulated by SLUG (SNAI2).
Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription.
Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development.
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.
The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex.
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development.
HDAC2 negatively regulates memory formation and synaptic plasticity.
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.
Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts.
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.
Chromatin regulation by Brg1 underlies heart muscle development and disease.
A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein.
Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.
A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.
KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription.
The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
lincRNAs act in the circuitry controlling pluripotency and differentiation.
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity.
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation.
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.
Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.
Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.
Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death.
Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.
Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis.
Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes.
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.
Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.
Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.
Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability.
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.
The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
Reactome pathway annotation
UniProt record for mouse Hdac1
OpenAI deep research report on mouse Hdac1
Falcon deep research report on mouse Hdac1
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HDAC1 is a complex-integrated nuclear lysine deacetylase in SIN3, NuRD, CoREST, and related chromatin regulatory complexes.
"HDAC1 is best annotated as a complex-integrated nuclear lysine deacetylase; modern evidence supports that most HDAC1 is embedded in corepressor complexes that specify function and genomic binding."