Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
-
KCTD11/REN identified as Hedgehog antagonist deleted in medulloblastoma
"we identify REN(KCTD11) as a suppressor of Hedgehog signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma"
-
Functions as tumor suppressor in cerebellar development
"REN(KCTD11) inhibits medulloblastoma cell proliferation and colony formation in vitro and suppresses xenograft tumor growth in vivo"
-
BTB domain required for growth-suppressing properties
"REN(KCTD11) seems to inhibit medulloblastoma growth by negatively regulating the Hedgehog pathway"
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
-
KCTD11 is substrate adaptor for CRL3 E3 ligase targeting HDAC1
"This mechanism is turned off by HDAC1 degradation through an E3 ubiquitin ligase complex formed by Cullin3 and REN"
-
HDAC1 degradation leads to GLI1 hyperacetylation and inactivation
"acetylation of Gli proteins functions as an unexpected key transcriptional checkpoint of Hedgehog signalling"
-
Mechanism of Hedgehog pathway suppression elucidated
"HDAC-mediated deacetylation promotes transcriptional activation and sustains a positive autoregulatory loop through Hedgehog-induced upregulation of HDAC1"
Molecular organization of the cullin E3 ligase adaptor KCTD11
-
Structural characterization of KCTD11-CUL3 interaction
"sKCTD11 is still able to bind Cul3, although to much lesser extent than lKCTD11, and to perform its biological activity"
-
BTB domain mediates oligomerization and CUL3 binding
"the protein likely forms stable tetramers"
Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma
-
KCASH subfamily (KCTD11/KCTD21/KCTD6) identified
"We identify and characterize here two REN(KCTD11) homologues, defining a new family of proteins named KCASH"
-
KCTD11 can hetero-oligomerize with KCTD6 and KCTD21
"the novel genes (KCASH2(KCTD21) and KCASH3(KCTD6)) share with REN(KCTD11) a number of features"
Cullin 3 recognition is not a universal property among KCTD proteins
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states
-
Electron microscopy demonstrates KCTD BTB domains form pentamers
"present electron microscopy data highlight the occurrence of well-defined pentameric states for all domains"
-
KCTD6(BTB)-Cullin3 complex visualized with five-pointed pinwheel shape
"negative-stain electron micrographs of KCTD6(BTB) in complex with Cullin3 show the presence of assemblies with a five-pointed pinwheel shape"
Deep research review of KCTD11 function
Cyberian deep research on KCTD11 function