Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor.
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
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PAG recruits CSK to membranes and inhibits Src kinases
"Expression of PAG in COS cells results in recruitment of endogenous Csk, altered Src kinase activity, and impaired phosphorylation of Src-specific substrates"
Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk.
Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
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Human CSK phosphorylates Lck Tyr-505 and suppresses Lck activity
"Here we characterize a human cytosolic 50 kDa protein tyrosine kinase, p50csk, which specifically phosphorylates Tyr-505 of p56lck and a synthetic peptide containing this site"
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin.
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.
Structural basis for the recognition of c-Src by its inactivator Csk.
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CSK substrate specificity for SFK tails is enforced by a kinase-kinase docking interface
"Csk cannot phosphorylate substrates that lack this docking mechanism because the conventional substrate binding site used by most tyrosine kinases to recognize substrates is destabilized in Csk by a deletion in the activation loop"
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).
The tyrosine kinase Csk dimerizes through Its SH3 domain.
The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.
Architecture of the human interactome defines protein communities and disease networks.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.
Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).
Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.
Sustained activation of SRC kinase by SHP2
Inactivation of Lck by Csk
Interaction of Csk with PAG
Integrin alphaIIb beta3 activation
Interaction of integrin alphaIIb beta3 with Fibrinogen
Clustering of Integrin alphaIIb beta3 complexes
Regulation of T cell activation by CD28 family
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
Interaction of SHP-1 or SHP-2 with phospho PD-1
Activated integrin alphaIIb beta3 binds SHC1
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
SHC1 dissociates from integrin alphaIIb beta3
PTPN22 dissociates from CSK
RHOH binds effectors at the plasma membrane
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
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Phosphotyrosine signalling machinery predates the choanoflagellate-metazoan split
"These findings support a model in which the full set of pTyr signalling machinery evolved before the separation of the choanoflagellate and metazoan lineages."
Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.
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A functional Csk-Src regulatory system exists in the choanoflagellate Monosiga ovata
"we show that the src gene family and its C-terminal Src kinase (Csk)-mediated regulatory system already were established in the unicellular M. ovata"
Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation.
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M. brevicollis Csk phosphorylates the Src tail but does not inhibit choanoflagellate Src as in mammals
"We cloned and expressed the M. brevicollis homolog of c-Src C-terminal kinase (MbCsk) and showed that it phosphorylates the C terminus of MbSrc1, yet this phosphorylation does not inhibit MbSrc to the same degree seen in the mammalian Src/Csk pair"
Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase.
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Csk-mediated Src inhibition reported for Capsaspora and M. brevicollis proteins (abstract only read)
"Our results suggest that negative regulation of Src by Csk is more ancient than previously thought and that it might be conserved across all holozoan species"