Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.
Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation.
Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner.
Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice.
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.
Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.
Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.
Molecular interactions between apoE and ABCA1: impact on apoE lipidation.
Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1.
Site-directed mutagenesis of an apolipoprotein E mutant, apo E5(Glu3
CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.
Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins.
Regulation of ApoE receptor proteolysis by ligand binding.
Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice.
Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids.
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.
Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF.
The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins.
Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.
Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Effects of exogenous apo E-3 and of cholesterol-enriched meals on the cellular metabolism of human chylomicrons and their remnants.
Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway.
Haptoglobin binds the antiatherogenic protein apolipoprotein E - impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes.
Defining the membrane proteome of NK cells.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Proteomics characterization of extracellular space components in the human aorta.
Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction.
Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex.
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β.
Proteomic characterization of the human sperm nucleus.
Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.
Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Search for amyloid-binding proteins by affinity chromatography.
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.
Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.
The importance of Wnt signalling for neurodegeneration in Parkinson's disease.
Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.
Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture.
Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model.
ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro.
Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro.
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.
Apolipoprotein E isoform-specific effects on lipoprotein receptor processing.
Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins.
The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.
Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells.
Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.
Effects of different isoforms of apoE on aggregation of the α-synuclein protein implicated in Parkinson's disease.
FRMD4A-cytohesin signaling modulates the cellular release of tau.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Apolipoprotein E mediates binding of normal very low density lipoprotein to heparin but is not required for high affinity receptor binding.
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.
Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease.
Architecture of the human interactome defines protein communities and disease networks.
α-Synuclein Interacts with Lipoproteins in Plasma.
Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity.
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.
High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Soluble LR11 competes with amyloid β in binding to cerebrospinal fluid-high-density lipoprotein.
α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Familial apolipoprotein E deficiency.
Behavior of human apolipoprotein E in aqueous solutions and at interfaces.
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2.
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth.
Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu).
Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study.
Isoform-specific binding of apolipoprotein E to beta-amyloid.
A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells.
Identification of disulfide-linked apolipoprotein species in human lipoproteins.
Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.
Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization.
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.
Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease.
Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma.
Association of human, rat, and rabbit apolipoprotein E with beta-amyloid.
Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide.
The HepG2 extracellular matrix contains separate heparinase- and lipid-releasable pools of ApoE. Implications for hepatic lipoprotein metabolism.
The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease.
Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.
Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase.
chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III
chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
chylomicron remnant + apoE => chylomicron remnant:apoE complex
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
LPL hydrolyses TGs from mature CMs
Nascent CMs transform into mature CMs
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
NREH hydrolyses atREs to atROL and FAs
CR:atREs binds apoE and HSPG
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed
Spherical HDL binds C and E apolipoproteins
The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK
FAM20C phosphorylates FAM20C substrates
Expression of APOE regulated by NR1H2 or NR1H3
APOE gene transcription is stimulated by ERBB4s80
Retinoid metabolism and transport
Amyloid fibrils have additional components