Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
A variant form of beta-actin in a mutant of KB cells resistant to cytochalasin B.
Antisense oligodeoxynucleotide complementary to smooth muscle alpha-actin inhibits endothelial-mesenchymal transformation during chick cardiogenesis.
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.
Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts.
Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy.
Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-beta1.
Development of glomerular endothelial cells, podocytes and mesangial cells in the human fetus and infant.
Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.
De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction.
Analysis of ACTA2 in European Moyamoya disease patients.
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
Smooth muscle α actin (Acta2) and myofibroblast function during hepatic wound healing.
Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin.
The defining pathology of the new clinical and histopathologic entity ACTA2-related cerebrovascular disease.
All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity.
SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle α-actin from the chaperonin-containing TCP1 folding complex.
Architecture of the human interactome defines protein communities and disease networks.
Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction.
A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms.
Visceral myopathy: Clinical and molecular survey of a cohort of seven new patients and state of the art of overlapping phenotypes.
Genomic Editing of a Pathogenic Sequence Variant in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice.
Immature Acta2(R179C/+) smooth muscle cells cause moyamoya-like cerebrovascular lesions in mice prevented by boosting OXPHOS.
Release Of ADP From Myosin
ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4
DGC complex binds AGRN and HSPG2
CDH1-associated CTNNA1 binds VCL
CDH1 forms homotypic trans-dimers
CDH1-associated CTNNA1 binds F-actin
ACTA2 computed analysis - structural-MF census, actin-surface residue tallies, disease-variant distances, WITH/FROM resolution, reference projection
UniProt P62736 ACTA2 cached record