AUR1 (YKL004W) notes

UniProt P36107, catalytic subunit of IPC synthase (EC 2.7.1.227); with Kei1 forms the IPC synthase complex; multipass Golgi membrane protein [UniProt:P36107].

• Genetic/biochemical identification PMID:9092515; aureobasidin A target PMID:9092515.
• Kinetics on PI and ceramide; AbA-resistant mutant has reduced Vmax PMID:19047657.
• Golgi, active site lumenal PMID:10888667.
• Kei1 essential subunit [PMID:19726565 "Aur1 and Kei1 proteins form a complex in vivo"; "Kei1 is essential for both the activity and the Golgi localization of IPC synthase"].

Pathway context

• YeastPathways: phytoceramide + PI -> IPC + DAG: correct; Aur1 is the catalytic subunit. EC now 2.7.1.227.
• RCA cytosol is wrong (lumenal Golgi active site).
• IBA "mannosyl diphosphorylinositol ceramide metabolic process" is from a PANTHER node that includes IPT1 (S000002479), the M(IP)2C synthase paralog; Aur1 makes IPC, not M(IP)2C.