PPP1R15B (CReP) review notes

Literature search (no deep-research provider available)

Sources checked: UniProt Q5SWA1 (curated FUNCTION, SUBUNIT, DISEASE); all 11 GOA-cited PMIDs cached via
just fetch-gene-pmids; PMID:14638860 (Jousse et al. 2003, CReP discovery; already cached for the ISR module).
Context only: integrated stress response module, crep_pp1_regulator annoton (module proposed in ai4curation/ai-gene-review#5904).

Key findings

• Constitutive eIF2alpha phosphatase subunit: PMID:14638860 (work largely in rodent cells)
• Human genetics: PMID:26307080
• Substrate recruitment: PMID:38159565; PMID:38159565
• Localization: no PPP1R15B-specific compartment found in these sources; ER rests only on IBA (GADD34-type targeting).

Source defect found

DisProt IPI rows (PMID:34847777, PMID:38159565) list UniProtKB:Q9BY44 (EIF2A, eIF-2A) as the eIF2 partner;
correct partner is EIF2S1 (P05198) (and EIF2S3 for the trimer contacts). Same issue as PPP1R15A.

Decisions

• PP1c protein-binding rows -> protein phosphatase 1 binding; TRIM23 HuRI row removed.
• negative regulation of protein phosphorylation (IMP) -> GO:0036496 (acts by dephosphorylation).
• molecular adaptor activity -> enzyme-substrate adaptor activity (GO:0140767).