Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.
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AIP overexpression destabilizes Aurora-A.
"Ectopic expression of AIP with Aurora-A in NIH 3T3 and COS cells results in the down-regulation of ectopically expressed Aurora-A protein levels, and this down-regulation is demonstrated to be the result of destabilization of Aurora-A through a proteasome-dependent protein degradation pathway."
A proteome-scale map of the human interactome network.
Ribosome. The structure of the human mitochondrial ribosome.
Structure and Function of the Mitochondrial Ribosome.
APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.
A reference map of the human binary protein interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
Hydrolysis of GTP and dissociation of 28S and 39S subunits
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
MRRF binds 55S ribosome:mRNA:tRNA
55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA
MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site
ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide
55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58)
Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.
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AURKAIP1 is mitoribosomal protein MRPS38.
"The newly identified MRPs are MRPS37 (Coiled-coil-helix-coiled-coil-helix domain containing protein 1-CHCHD1), MRPS38 (Aurora kinase A interacting protein1, AURKAIP1), MRPS39 (Pentatricopeptide repeat-containing protein 3, PTCD3), in the small subunit and MRPL59 (CR-6 interacting factor 1, CRIF1) in"
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AURKAIP1 knockdown impairs mitochondrial protein synthesis.
"Furthermore, we have demonstrated the essential roles of CHCHD1, AURKAIP1, and CRIF1in mitochondrial protein synthesis by siRNA knock-down studies, which had significant effects on the expression of mitochondrially encoded proteins."
Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.
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AURKAIP1 promotes ubiquitin-independent proteasomal degradation of Aurora-A.
"In an attempt to investigate the mechanism of AURKAIP1-mediated Aurora-A degradation, we report here that AURKAIP1 targets Aurora-A for degradation in a proteasome-dependent but Ub (ubiquitin)-independent manner."
Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
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Antizyme1 mediates AURKAIP1-dependent Aurora-A degradation.
"In an attempt to understand how AURKAIP1 promotes Aurora-A degradation through Ub-independent pathway, we demonstrate here that antizyme1 (Az1), a well-studied mediator of Ub-independent protein degradation pathway, regulates Aurora-A protein stability."
The mitoribosome-specific protein mS38 is preferentially required for synthesis of cytochrome c oxidase subunits.
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Yeast mS38 is preferentially required for COX1-3 translation initiation.
"Additionally, the absence of mS38 preferentially disturbs translation initiation of COX1, COX2, and COX3 mRNAs, without affecting the levels of mRNA-specific translational activators."
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mS38 is proposed as an intrinsic ribosomal translational regulator.
"We propose that mS38 confers the mitochondrial ribosome an intrinsic capacity of translational regulation, probably acquired during evolution from bacterial ribosomes to facilitate the translation of mitochondrial mRNAs, which lack typical anti-Shine-Dalgarno sequences."
COX24 codes for a mitochondrial protein required for processing of the COX1 transcript.
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Yeast COX24 is required for COX1 RNA processing.
"Here we show that the low molecular weight protein product of open reading frame YLR204W, for which we propose the name COX24, is also involved in processing of COX1 RNA intermediates."
UniProt entry Q9NWT8 (AKIP_HUMAN)
Affinage mechanistic annotation for AURKAIP1 (human)