Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.
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Mouse CNNM4 localizes to the basolateral membrane of ameloblasts and intestinal epithelia and extrudes Mg2+ in a Na+-dependent manner; knockout mice have defective intestinal Mg2+ absorption and amelogenesis.
"Functional analyses at the molecular and organismal levels revealed a common role for CNNM4 in mediating transcellular Mg2+ transport by basolateral Mg2+ extrusion."
Dynamic dimer-of-dimers architecture defines Mg(2+) transport in human CNNM4.
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Full-length human CNNM4 forms an MgATP-dependent asymmetric tetramer and its conformational cycle promotes Mg2+/Na+ exchange.
"Tetramerization is MgATP-dependent, with the intracellular modules remaining highly dynamic otherwise."
CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells.
Mutations in CNNM4 cause Jalili syndrome, consisting of autosomal-recessive cone-rod dystrophy and amelogenesis imperfecta.
Dog CNNM4 sequence comparison with human CNNM4 and CNNM2
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A0A8I3PI07 is a full-length CNNM4 ortholog (93% identity to human CNNM4, 66% to CNNM2) with a ~21-aa C-terminal insertion outside the transport and CBS regions.
"The benchmark accession is a full-length CNNM4 gene model, not a fragment."