Exact Q8IRM9 is the 230-residue CG32706-PA protein, with an ABT1/Esf2-specific InterPro classification and RRM at residues 62–140. PMID:15964808(https://pubmed.ncbi.nlm.nih.gov/15964808/), DOI https://doi.org/10.1128/MCB.25.13.5523-5534.2005, is cached with full text and experimentally establishes the yeast homolog’s early rRNA-processing and processome-assembly function. The GOA IBA sources include yeast Esf2; this is a conserved family transfer with a characterized mechanism, not a donor-count argument. The provided ProtNLM paragraph is already reflected in those existing annotations.
The original phmmer donor O74362 is fission-yeast Esf2, whose identical UniProt functional paragraph is itself by-similarity. The direct experimental anchor is the budding-yeast paper, not repetition of the donor paragraph. PMID:18245331(https://pubmed.ncbi.nlm.nih.gov/18245331/) remains abstract-only: both PMC and EuropePMC full-text attempts failed. The specific defense-versus-endurance mutant classification cannot be checked, so its experimental GO annotation remains UNDECIDED.
The selected frozen UniProt record is retained in CG32706-uniprot-source.json, with the complete original prediction metadata in CG32706-predictions-source.json. It maps the exact accession to this FlyBase gene; current sequence identity does not establish the historical predictor input. Gene-level experiments support conserved functions unless a relevant isoform difference is established. Falcon research was requested with perplexity-lite fallback alongside publication caching. Primary publications and sequence observations, rather than AI summaries or ARBA assertions, support the curated conclusions.
The completed Falcon report was inspected. It supports the Esf2 family-based ribosome-biogenesis inference and identifies additional yeast Dbp8 cofactor experiments, but no direct fly reaction. The broad SSU-processome/18S narrative claims are CNN; the precise requirement at yeast-named A0/A1/A2 sites is separately UNC because target site correspondence and requirement are not established. Broad conservation does not validate exact site names.
The full Falcon output was inspected. It supports the conserved Esf2 mechanism while identifying uncertainty about exact fly RNA contacts; no yeast experiment is labeled as direct fly evidence.