Gene Ontology electronic annotation based on InterPro domain mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Nucleotide sequence of the tail tube structural gene of bacteriophage T4.
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Determines the nucleotide sequence of bacteriophage T4 gene 19 and confirms the N- and C-terminal amino acid sequences of purified tail tube protein gp19.
"The nucleotide sequence of gene 19 of bacteriophage T4, the structural gene of the tail tube protein, was determined by both the dideoxy and the Maxam-Gilbert methods. The predicted Mr of tube protein gene product 19 is 18,842."
UniProtKB record for P13333 (19_BPT4)
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gp19 forms the central rigid hexameric tail tube atop the gp48 and gp54 rings and serves as the DNA ejection channel when driven through the host outer membrane by gp18 sheath contraction.
"Forms the central cylindrical rigid tube, which is surrounded by the outer contractile sheath assembled from gp18 subunits. The tail tube first 2 annuli are formed by gp48 and gp54, which are in continuation of the spike complex. During infection, contraction of the sheath drives the central tube through the host outer membrane, creating a channel for DNA ejection from the capsid into the host cell."
Deep research summary for Bacteriophage T4 gene 19 (gp19)
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gp19 polymerizes into stacked hexameric rings around the tape measure protein gp29 to form the inner tail tube conduit for dsDNA translocation.
"gp19 polymerizes into stacked hexameric rings around the tape measure protein (TMP) gp29, which occupies the lumen during assembly and is anchored in the baseplate"