ID   OLM2A_MOUSE             Reviewed;         681 AA.
AC   Q8BHP7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   02-SEP-2026, entry version 137.
DE   RecName: Full=Olfactomedin-like protein 2A;
DE   AltName: Full=Photomedin-1;
DE   Flags: Precursor;
GN   Name=Olfml2a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Urinary bladder;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   PROTEIN SEQUENCE OF 33-42 AND 301-310, SUBUNIT, CLEAVAGE SITE,
RP   GLYCOSYLATION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=15836428; DOI=10.1042/bj20050120;
RA   Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Fukuda S.,
RA   Kawai J., Sugiura N., Kimata K., Hayashizaki Y., Sekiguchi K.;
RT   "Identification and characterization of photomedins: novel olfactomedin-
RT   domain-containing proteins with chondroitin sulphate-E-binding activity.";
RL   Biochem. J. 389:675-684(2005).
CC   -!- SUBUNIT: Homodimer. Binds to heparin and chondroitin sulfate E.
CC       {ECO:0000269|PubMed:15836428}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15836428}.
CC   -!- TISSUE SPECIFICITY: Expressed in lung, eye, testis, uterus, ovary, and
CC       to a lesser extent in heart, skeletal muscle, mammary gland, skin and
CC       prostate. Within the eye, mainly present in photoreceptor layers (at
CC       protein level). {ECO:0000269|PubMed:15836428}.
CC   -!- PTM: Seems to be cleaved at Lys-301 after secretion.
CC       {ECO:0000269|PubMed:15836428}.
CC   -!- PTM: O-glycosylated but not N-glycosylated.
CC       {ECO:0000269|PubMed:15836428}.
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DR   EMBL; AK035313; BAC29029.1; -; mRNA.
DR   EMBL; AL844588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL935155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS16013.1; -.
DR   RefSeq; NP_766442.1; NM_172854.2.
DR   AlphaFoldDB; Q8BHP7; -.
DR   SMR; Q8BHP7; -.
DR   BioGRID; 232309; 1.
DR   FunCoup; Q8BHP7; 248.
DR   STRING; 10090.ENSMUSP00000058761; -.
DR   GlyGen; Q8BHP7; 2 sites, 1 N-linked glycan (2 sites).
DR   iPTMnet; Q8BHP7; -.
DR   PhosphoSitePlus; Q8BHP7; -.
DR   PaxDb; 10090-ENSMUSP00000058761; -.
DR   ProteomicsDB; 289987; -.
DR   Antibodypedia; 16348; 149 antibodies from 26 providers.
DR   Ensembl; ENSMUST00000057279.6; ENSMUSP00000058761.6; ENSMUSG00000046618.8.
DR   GeneID; 241327; -.
DR   KEGG; mmu:241327; -.
DR   UCSC; uc008jnv.1; mouse.
DR   AGR; MGI:2444741; -.
DR   CTD; 169611; -.
DR   MGI; MGI:2444741; Olfml2a.
DR   VEuPathDB; HostDB:ENSMUSG00000046618; -.
DR   eggNOG; KOG3545; Eukaryota.
DR   GeneTree; ENSGT00940000157194; -.
DR   HOGENOM; CLU_024107_0_0_1; -.
DR   InParanoid; Q8BHP7; -.
DR   OMA; FRNEHAY; -.
DR   OrthoDB; 8626508at2759; -.
DR   PhylomeDB; Q8BHP7; -.
DR   BioGRID-ORCS; 241327; 4 hits in 78 CRISPR screens.
DR   PRO; PR:Q8BHP7; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8BHP7; protein.
DR   Bgee; ENSMUSG00000046618; Expressed in lumbar dorsal root ganglion and 90 other cell types or tissues.
DR   ExpressionAtlas; Q8BHP7; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR   GO; GO:0050840; F:extracellular matrix binding; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR   GO; GO:0030198; P:extracellular matrix organization; IDA:MGI.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR050605; Olfactomedin-like_domain.
DR   PANTHER; PTHR23192:SF29; OLFACTOMEDIN-LIKE PROTEIN 2A; 1.
DR   PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000269|PubMed:15836428"
FT   CHAIN           33..681
FT                   /note="Olfactomedin-like protein 2A"
FT                   /id="PRO_0000311429"
FT   DOMAIN          423..681
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   REGION          216..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..226
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..315
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..353
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..400
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..413
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            300..301
FT                   /note="Cleavage"
FT   DISULFID        424..611
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   681 AA;  76547 MW;  89B22A48BECC66BD CRC64;
     MEAAAVLPRY LQLRLLLVLL LLVLLRAGPV WPDSKVFSDL DQVRMTSEGS DCRCKCIMRP
     LSKDACSRVR SGRARVEDFY TVETVSSGAD CRCSCTAPPS SLNPCENEWK MEKLKKQAPE
     LLKLQSMVDL LEGALYSMDL MKVHAYIQKV ASQMNTLEES IKANLSLENK VVKDSVHHLS
     EQLKSYENQS AIMMSIKKEL SSLGLQLLQR DAAAVPATAP ASSPDSKAQD TAGGQGRDLN
     KYGSIQKSFS DKGLAKPPKE KLLKVEKLRK ESIKGRIPQP TARPRALAQQ QAVIRGFTYY
     KAGRQEARQE ARQEAPKAAA DSTLKGTSWL EKLPPKIEAK LPEPNSAKHD DVRLQASEGG
     NLTPDITTTT TSTSSSTTTT TGTTSTTSTT STTSTTTPSP ITTPWPTEPP LHPEVPSQGR
     EDSCEGTLRA VDPPVKHHSY GRHEGAWMKD PAALDDRIYV TNYYYGNSLV EFRNLENFKQ
     GRWSNMYKLP YNWIGTGHVV YQGAFYYNRA FTKNIIKYDL RQRFVASWAL LPDVVYEDTT
     PWKWRGHSDI DFAVDESGLW VIYPAVDEHD ETQHEVIVLS RLDPADLSVH RETTWKTRLR
     RNSYGNCFLV CGILYTVDTY NQHEGQVAYA FDTHTGTDAH PQLPFLNEYS YTTQVDYNPK
     ERVLYAWDNG HQLTYTLHFV V
//