id: A0A8C9H4D2 gene_symbol: OLFML2A taxon: id: NCBITaxon:591936 label: Piliocolobus tephrosceles status: COMPLETE description: >- The OLFML2A subfamily assignment and experimentally grounded mouse Olfml2a annotations support inferred extracellular matrix localization and involvement in matrix organization. These are ortholog-based gene-product inferences; secretion and function of the deposited 439-residue primate sequence have not been demonstrated. source_documents: - genes/9PRIM/A0A8C9H4D2/A0A8C9H4D2-uniprot.txt - genes/9PRIM/A0A8C9H4D2/A0A8C9H4D2-goa.tsv - publications/PMID_15836428.md - genes/9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-uniprot.txt - genes/9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-matrix-organization-quickgo.json - publications/PMID_18757743.md predictions: - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0031012 label: extracellular matrix predicted_term_type: GO_CC review: assessment: COR confidence_score: 2 summary: >- The primate target and mouse photomedin-1 (Olfml2a; Q8BHP7) share the OLFML2A PANTHER subfamily PTHR23192:SF29. Mouse photomedin-1 was experimentally secreted as a disulfide-bonded dimer; the photomedins bound chondroitin sulphate-E and heparin, supporting association with extracellular glycosaminoglycans (PMID:15836428). This supports an inferred matrix-associated location for the OLFML2A gene product rather than transferring a generic olfactomedin-domain property. The 439-residue primate record lacks an annotated signal peptide, so secretion of that deposited sequence is not demonstrated; the assignment relies on conserved ortholog biology, not on an observed targeting signal in this record. Matrix association is absent from the cached target annotations, making COR appropriate for this explicitly inferred localization. Matrix organization is assessed separately using the mouse experimental process annotation. supported_by: - reference_id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-uniprot.txt supporting_text: >- ID A0A8C9H4D2_9PRIM Unreviewed; 439 AA. ... DR InterPro; IPR003112; Olfac-like_dom. ... DR PANTHER; PTHR23192:SF29; OLFACTOMEDIN-LIKE PROTEIN 2A; 1. ... FT DOMAIN 181..439 ... FT /note="Olfactomedin-like" - reference_id: PMID:15836428 supporting_text: >- preferentially bound to chondroitin sulphate-E and heparin - reference_id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-uniprot.txt supporting_text: >- ID OLM2A_MOUSE Reviewed; 681 AA. ... DE AltName: Full=Photomedin-1; ... GN Name=Olfml2a; ... CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15836428}. ... DR GO; GO:0031012; C:extracellular matrix; IDA:MGI. ... DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. ... DR PANTHER; PTHR23192:SF29; OLFACTOMEDIN-LIKE PROTEIN 2A; 1. ... FT SIGNAL 1..32 ... FT DOMAIN 423..681 ... FT /note="Olfactomedin-like" - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0030198 label: extracellular matrix organization predicted_term_type: GO_BP review: assessment: COR confidence_score: 2 summary: >- Mouse photomedin-1 (Olfml2a; Q8BHP7) has an MGI IDA annotation to extracellular matrix organization, with the relation acts_upstream_of_or_within. The QuickGO record identifies PMID:18757743 as its source: a study that includes functional ECM-assembly assays. This is distinct from the secretion and glycosaminoglycan-binding evidence in PMID:15836428. The experimentally grounded curated process annotation, together with the matching OLFML2A PANTHER subfamily PTHR23192:SF29, supports transfer of a broad involvement in matrix organization to the primate gene product. COR denotes this ortholog-based inference, not a demonstrated matrix-remodeling mechanism or an assay of the deposited 439-residue sequence. The process is absent from the cached target annotations. supported_by: - reference_id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-uniprot.txt supporting_text: >- ID A0A8C9H4D2_9PRIM Unreviewed; 439 AA. ... DR InterPro; IPR003112; Olfac-like_dom. ... DR PANTHER; PTHR23192:SF29; OLFACTOMEDIN-LIKE PROTEIN 2A; 1. ... FT DOMAIN 181..439 ... FT /note="Olfactomedin-like" - reference_id: PMID:15836428 supporting_text: >- preferentially bound to chondroitin sulphate-E and heparin - reference_id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-uniprot.txt supporting_text: >- ID OLM2A_MOUSE Reviewed; 681 AA. ... DE AltName: Full=Photomedin-1; ... GN Name=Olfml2a; ... CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15836428}. ... DR GO; GO:0030198; P:extracellular matrix organization; IDA:MGI. ... DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. ... DR PANTHER; PTHR23192:SF29; OLFACTOMEDIN-LIKE PROTEIN 2A; 1. ... FT SIGNAL 1..32 ... FT DOMAIN 423..681 ... FT /note="Olfactomedin-like" - reference_id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-matrix-organization-quickgo.json supporting_text: >- "geneProductId": "UniProtKB:Q8BHP7", "qualifier": "acts_upstream_of_or_within", "goId": "GO:0030198", "goName": null, "goEvidence": "IDA" ... "reference": "PMID:18757743" ... "assignedBy": "MGI" ... "symbol": "Olfml2a" - reference_id: PMID:18757743 supporting_text: >- These assays screened the candidate proteins for ECM-assembling activities references: - id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-uniprot.txt title: A0A8C9H4D2-uniprot.txt - id: PMID:15836428 title: 'Identification and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity.' - id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-uniprot.txt title: Q8BHP7-uniprot.txt - id: file:9PRIM/A0A8C9H4D2/A0A8C9H4D2-prediction-evidence/Q8BHP7-matrix-organization-quickgo.json title: Q8BHP7-matrix-organization-quickgo.json - id: PMID:18757743 title: Transcriptome-based systematic identification of extracellular matrix proteins.