id: A0A6I8TLE4
gene_symbol: A0A6I8TLE4
taxon:
  id: NCBITaxon:7159
  label: Aedes aegypti
status: COMPLETE
description: >-
  The RasGAP domain and conserved-site assignments support GTPase activation. The same molecular function
  is already recorded in UniProt.
source_documents:
  - genes/AEDAE/A0A6I8TLE4/A0A6I8TLE4-uniprot.txt
  - genes/AEDAE/A0A6I8TLE4/A0A6I8TLE4-goa.tsv
  - publications/PMID_12787671.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005096
      label: GTPase activator activity
    predicted_term_type: GO_MF
    review:
      assessment: CNN
      confidence_score: 2
      summary: >-
        The target contains a RasGAP domain and the RasGAP conserved-site signature, alongside PH and
        C2 domains. Mutational analysis of characterized RasGAPs establishes that conserved RasGAP elements
        stimulate GTP hydrolysis by the bound GTPase (PMID:12787671); this supports transfer of the broad
        GTPase activator activity to the target without specifying a substrate beyond the available evidence.
        The exact GO term is present in the cached UniProt record, although the local GOA export is empty.
        Correctness rests on the domain and mechanistic evidence, while the existing annotation establishes
        overlap only.
      supported_by:
        - reference_id: file:AEDAE/A0A6I8TLE4/A0A6I8TLE4-uniprot.txt
          supporting_text: >-
            ID   A0A6I8TLE4_AEDAE        Unreviewed;      1442 AA. ... DR   GO; GO:0005096; F:GTPase activator
            activity; IEA:UniProtKB-KW. ... DR   InterPro; IPR023152; RasGAP_CS. ... DR   InterPro; IPR001936;
            RasGAP_dom. ... DR   PANTHER; PTHR10194:SF60; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
        - reference_id: PMID:12787671
          supporting_text: >-
            The finger loop is crucial for the stabilization of the transition state
references:
  - id: file:AEDAE/A0A6I8TLE4/A0A6I8TLE4-uniprot.txt
    title: A0A6I8TLE4-uniprot.txt
  - id: PMID:12787671
    title: Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.