ID   A0A6I8TLE4_AEDAE        Unreviewed;      1442 AA.
AC   A0A6I8TLE4;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   10-JUN-2026, entry version 19.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AAEL019982-PE};
GN   Name=5579847 {ECO:0000313|EnsemblMetazoa:AAEL019982-PE};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL019982-PE, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EnsemblMetazoa:AAEL019982-PE}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019982-PE};
RG   Aedes aegypti Genome Working Group (AGWG);
RA   Matthews B.J.;
RT   "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AAEL019982-PE}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019982-PE};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EnsemblMetazoa; AAEL019982-RE; AAEL019982-PE; AAEL019982.
DR   OrthoDB; 5572587at2759; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd13262; PH_RasSynGAP-like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.506.10; GTPase Activation - p120gap, domain 1; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR057606; SynGAP1-like_PH.
DR   PANTHER; PTHR10194:SF60; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 1.
DR   Pfam; PF25321; PH_RASGAP; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT   REGION          132..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          959..988
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1211..1316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1421..1442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..749
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        968..983
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1258..1270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1421..1430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1431..1442
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1442 AA;  160969 MW;  29739A894824F325 CRC64;
     MMRRRAPNRF SCINFPSRVE GWLDFYETEG QSARSVNVPW GPLYCVLQQD EQTLTSYCSE
     ELSIFPLTPK KDAKLTDVLF AELPRVRLDQ PPKLQNMKTI WETAHPTLQE EPEEDGAEHH
     IQHNTSLRSA LDTSYEKACR RGSAPSTPIL GQKSESTSRF TNFFSKRSFR SNPLKRTKSV
     TKLERSKRGQ GGLRGSRSHE SLLSNHAVMS TIDLSCIGAI GVVPVHASVL GRRHCFQVRG
     GPRGERYYSC GSRQERDLWI YSLRKSIAPN AENTRRTDNS LKMWVYEAKA LPPKKKYFCE
     INLDKTLYGR TSVKLRTELL FWGEYFDFPD VPDINVITVN VYREGEKKKK RDKHALVGSV
     KIPIHEVTSR TFSEDWYPII SDKHDSISKN SSKEPIPTLR IKCRFQSIDI LPFGVYQDFL
     DYLKENYKKV CEMLEPVIGV KAKEDIGQAL VLLMHAQGMA AAFLTDVVAL DLLRVGDQRL
     TFRGNSLATK SMEAFLKLTG EQYLQDTLSS PISEIISSDR DCEVDPLKAN GSLSRQQQAL
     RNAVKTAWNS IADSSKSFPT QLRDCFSTFR ERLQMLDRED MADNLISASI FLRFLCPAIL
     SPSLFNITNE LPSARATRNL TLVAKTLQTL ANFTRFQGKE NFMEFLNDFL ENEAPRMKQF
     LHDISTRSEN PMQESILDWA VYIDQGKQLS ILHTLLAESI QKLPASKQID LHPLPNILES
     ITAAKETNSF ITTQQQNPQP QPHPNQENQS LSIAPLKSTE RGIIRGVLTP TSLEKNIFRY
     NDPTVRPLLS QNQSSNSLQH SHSTSSINSA TNLHVVSPTI QHHNMSSTNN SNDNKYQYQV
     GSMRTYGTVS QYYNNSSNIG SLKNEKEKSP VLNCGIRAST LPRNNPITVS NGTLSGEPEE
     PNNPTNLIQI GFDPSNAFNR KSPTPLLKSS THINGSRSRN LNGSQLSLLS DIGKNPLSLG
     IPHSEMVTST TPTPTQTQSN PSNMPMSLDD LEDLLNYADE QNIENQKGKE QLTSKGSNIS
     IGQISNICSS GYQSITTQSQ SSSPVELGQQ QIEYVANKVP PPRKINNKYG YISQRFTPAN
     NSNMTNLNNN NDQDDHYAPL PYKNPLYHQT ANGNTGSALN AYNNNLIIGS NVTSGNSGLI
     NGGGVYKSHL STIGSGGNLH TSSSDERLSN NDNYRDLDSL NTVNGNGYDS FGGLHGRRLG
     SSRMPRTNPL MQYKREEPLD IQPVGSYPTG GSNARDHHHH SNSGGGNSRY QRRMSIDSGR
     TLSDSSTDTE SGPKPHHHSV SLGLVGPGTV HLGLMGSGGA HSESKRRYHR TSTSKSVEQC
     EREIQRLQAS VDELRQKLEE SELKEVSEDR EAISHHSDSK IRSIIGRLLA MEEELRREQY
     KMSLVLSHKQ RVIEAQGQQI AALDAANNRL LTALSSLRNR YENQSNQSDT SSPAPNASAS
     SC
//