Heat-inducible transcription factor that functions downstream of HSFA1 to amplify heat-stress transcription and extend acquired thermotolerance during recovery from heat stress. HSFA2 binds heat shock elements in target promoters, activates stress-protective genes such as APX2 and heat shock protein genes, and participates in chromatin-level thermomemory circuits including the REF6-HSFA2 feedback loop described for transgenerational heat acclimation. Distinct from constitutively expressed HSFA1 master regulators, HSFA2 is strongly heat inducible and is especially important for acquired and sustained thermotolerance rather than basal heat tolerance.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0003700 DNA-binding transcription factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: HSFA2 is a bona fide transcription factor with DNA-binding activity specific for heat shock elements (HSE) with consensus sequence AGAAnnTTCT. This is a core molecular function supported by phylogenetic inference and extensive experimental evidence. Reason: This annotation correctly captures HSFA2's core molecular function as a DNA-binding transcription factor. The IBA evidence is supported by multiple experimental studies showing direct DNA binding to HSE sequences [PMID:19352026]. HSFA2 contains a conserved DNA-binding domain with helix-turn-helix motif characteristic of HSF family members [deep-research]. This is a CORE function. Supporting Evidence: PMID:19352026 Electrophoretic mobility shift assay demonstrated that the increase in protein complex formation onto the HSE was markedly suppressed during high-light stress and recovery from the stress in knockout HsfA2 plants file:ARATH/AT2G26150/AT2G26150-deep-research-perplexity.md HSFA2 functions fundamentally as a transcriptional activator that binds to heat shock element sequences in the promoters of target genes to modulate their expression |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: HSFA2 binds to HSE sequences in promoter regions to regulate RNA polymerase II-dependent transcription. This accurately captures the regulatory mechanism. Reason: This IBA annotation correctly represents HSFA2's function in binding cis-regulatory regions (HSEs) to control Pol II transcription. HSFA2 directly binds promoters of target genes like SGIP1, HSPs, and APX2 [PMID:30778176, deep-research]. This is a CORE molecular function. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: HSFA2 localizes to the nucleus where it performs its transcriptional regulatory function. Nuclear localization is essential for HSFA2's core function. Reason: HSFA2 accumulates in the nucleus during heat stress and this is where it binds chromatin and activates transcription [PMID:20521085, deep-research]. The protein contains an NLS and shuttles between cytoplasm and nucleus with nuclear function being critical. This is CORE cellular component. Supporting Evidence: |
| GO:0034605 cellular response to heat | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: HSFA2 participates in the cellular response to heat, but the broad heat-response term should be treated as non-core relative to the better supported acquired thermotolerance and thermomemory annotations. Reason: The broad cellular response to heat term is not wrong because HSFA2 is heat inducible and contributes to heat-stress transcriptional programs. It should not be replaced wholesale by heat acclimation here, because this IBA annotation does not itself establish the more specific acquired-memory process. Retain it as a broad, non-core heat-response annotation. |
| GO:0003677 DNA binding | IEA GO_REF:0000043 | ACCEPT | Summary: Generic DNA binding annotation based on InterPro domain. While technically correct, this is redundant with more specific annotations already present. Reason: HSFA2 binds DNA through its conserved HSF DNA-binding domain. However, the more specific GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding) better captures the actual function. Keeping this as it represents the general molecular capability, though not the most informative annotation. |
| GO:0003700 DNA-binding transcription factor activity | IEA GO_REF:0000002 | ACCEPT | Summary: Duplicate of IBA annotation already reviewed above. Electronic inference from InterPro domain. Reason: Same as IBA annotation - correctly captures core TF function. Redundant but consistent. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Electronic inference of nuclear localization from UniProt subcellular location. Reason: Duplicate of IBA annotation already reviewed. HSFA2 is indeed nuclear. Consistent and correct. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: HSFA2 does localize to cytoplasm under certain conditions, particularly under non-stress conditions due to its nuclear export signal. Reason: While HSFA2 shuttles between cytoplasm and nucleus [deep-research], its functional activity occurs in the nucleus. Cytoplasmic localization represents a regulatory state (sequestration) rather than the site of core function. The NES dominates over NLS under non-stress conditions causing cytoplasmic accumulation, but this is NON-CORE. |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000002 | ACCEPT | Summary: Generic term for transcriptional regulation. Correct but not specific to HSFA2's unique role. Reason: HSFA2 does regulate DNA-templated transcription as a core function. This broad term is accurate though less informative than the positive regulation term (GO:0045893) annotated elsewhere. |
| GO:0043565 sequence-specific DNA binding | IEA GO_REF:0000002 | ACCEPT | Summary: HSFA2 binds specific HSE sequences (AGAAnnTTCT consensus). Accurate molecular function. Reason: HSFA2 exhibits sequence-specific DNA binding to heat shock elements. This is a CORE molecular function supported by EMSA and ChIP experiments [PMID:19352026]. |
| GO:0003677 DNA binding | IPI PMID:39102897 Suppression of SMXL4 and SMXL5 confers enhanced thermotolera... | ACCEPT | Summary: Physical interaction evidence for DNA binding from recent 2024 study on SMXL4/5 regulation of HSFA2. Reason: This experimental evidence (IPI - inferred from physical interaction) supports HSFA2's DNA binding activity. The study reports that HSFA2 directly bound the SMXL4 and SMXL5 promoters during heat-stress recovery, consistent with HSFA2 acting as an HSE-binding transcription factor. Supporting Evidence: PMID:39102897 In addition, HSFA2 directly bound to the SMXL4 and SMXL5 promoters, inducing their expression during recovery from HS. |
| GO:0000976 transcription cis-regulatory region binding | IDA PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: Direct experimental evidence from transgenerational thermomemory study showing HSFA2 binds promoter regions. Reason: PMID:30778176 demonstrates HSFA2 directly binds to the SGIP1 promoter and activates its expression in heat-acclimated plants. This is CORE molecular function with strong experimental support (IDA - direct assay). Supporting Evidence: PMID:30778176 Further, we detected direct binding of HSFA2 to the SGIP1 promoter HSEs in vitro. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: Direct assay evidence from transgenerational memory study confirming transcription factor activity. Reason: Strong experimental evidence for HSFA2's transcriptional activation function. CORE molecular function. Supporting Evidence: PMID:30778176 Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6). |
| GO:0009408 response to heat | IEP PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | KEEP AS NON CORE | Summary: HSFA2 expression pattern shows induction by heat. However, this general term does not capture HSFA2's specific role in MEMORY/RECOVERY versus immediate response. Reason: While HSFA2 is induced by heat (IEP - inferred from expression pattern), this annotation misses the critical distinction that HSFA2 functions in ACQUIRED thermotolerance and transgenerational memory, not immediate heat response. The more specific GO:0010286 (heat acclimation) better captures HSFA2's role. Marking as NON-CORE because the term conflates HSFA2 with HSFA1. Supporting Evidence: PMID:30778176 HSFA2 remained upregulated in the progeny of heat-stressed plants at both transcript (a) and protein (b) levels. |
| GO:0010286 heat acclimation | IMP PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: This is THE core biological process for HSFA2. Heat acclimation captures the acquired/extended thermotolerance and transgenerational memory function. Reason: EXCELLENT annotation with strong mutant phenotype evidence (IMP). PMID:30778176 shows HSFA2 is required for transgenerational thermomemory and the REF6-HSFA2 feedback loop that enables heritable heat acclimation. This is HSFA2's PRIMARY CORE FUNCTION distinguishing it from HSFA1 [deep-research, notes]. Supporting Evidence: PMID:30778176 The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. |
| GO:0043565 sequence-specific DNA binding | IDA PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: Direct assay evidence for sequence-specific binding to HSEs. Duplicate but consistent with other annotations. Reason: CORE molecular function - sequence-specific binding to heat shock elements. Supporting Evidence: PMID:30778176 we detected direct binding of HSFA2 to the SGIP1 promoter HSEs in vitro |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: Direct evidence that HSFA2 activates transcription of target genes like SGIP1, REF6. Reason: HSFA2 functions as a transcriptional activator, not repressor. Strong experimental evidence. CORE function. Supporting Evidence: PMID:30778176 The expression of SGIP1 was dramatically decreased in hsfa2 plants |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: Mutant phenotype evidence supporting transcriptional activation role. Reason: Consistent with IDA annotation above. CORE function with mutant phenotype support. Supporting Evidence: PMID:30778176 The expression of SGIP1 was dramatically decreased in hsfa2 plants |
| GO:1990841 promoter-specific chromatin binding | IDA PMID:30778176 An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates t... | ACCEPT | Summary: Key annotation capturing HSFA2's chromatin-level regulatory mechanism. Reason: Excellent annotation. HSFA2 binds chromatin at specific target promoters in the heat-acclimation/thermomemory program, including the REF6-HSFA2 regulatory loop reported in PMID:30778176. This captures the chromatin-associated regulatory dimension of HSFA2 function without over-specifying HSFA2 as the enzyme that writes histone marks. Supporting Evidence: PMID:30778176 Further, we detected direct binding of HSFA2 to the SGIP1 promoter HSEs in vitro. |
| GO:0000976 transcription cis-regulatory region binding | IPI PMID:22037706 Enhanced Y1H assays for Arabidopsis. | ACCEPT | Summary: Enhanced Y1H assay evidence. High-throughput yeast one-hybrid screen. Reason: This is from an enhanced Y1H assay screen for Arabidopsis transcription factor-promoter interactions. While high-throughput, the IPI evidence supports cis-regulatory binding. CORE function. Supporting Evidence: PMID:22037706 Enhanced Y1H assays for Arabidopsis. |
| GO:0000976 transcription cis-regulatory region binding | IPI PMID:25533953 An Arabidopsis gene regulatory network for secondary cell wa... | ACCEPT | Summary: Evidence from secondary cell wall synthesis regulatory network study. Reason: While this annotation comes from a study focused on secondary cell wall synthesis rather than HSFA2's primary heat stress role, the molecular function "transcription cis-regulatory region binding" is indeed a core activity of HSFA2 as a transcription factor. The annotation is technically correct even if derived from a non-core biological context. Supporting Evidence: PMID:25533953 An Arabidopsis gene regulatory network for secondary cell wall synthesis. |
| GO:0000976 transcription cis-regulatory region binding | IPI PMID:27650334 Transcriptional Regulation of Arabidopsis Polycomb Repressiv... | ACCEPT | Summary: Evidence from Polycomb repressive complex study on transcriptional regulation. Reason: While this study focuses on PRC2 regulation rather than HSFA2's primary heat stress role, the molecular function "transcription cis-regulatory region binding" accurately describes HSFA2's core activity as a transcription factor. The annotation is correct even if identified in a different biological context. Supporting Evidence: PMID:27650334 Sep 20. Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation. |
| GO:0000976 transcription cis-regulatory region binding | IPI PMID:30356219 Transcriptional regulation of nitrogen-associated metabolism... | ACCEPT | Summary: Evidence from nitrogen metabolism and growth regulation study. Reason: While this study focuses on nitrogen metabolism rather than HSFA2's primary heat stress role, the molecular function "transcription cis-regulatory region binding" accurately describes HSFA2's core activity as a transcription factor. The annotation is correct even if identified in a different biological context. Supporting Evidence: PMID:30356219 Oct 24. Transcriptional regulation of nitrogen-associated metabolism and growth. |
| GO:0000976 transcription cis-regulatory region binding | IPI PMID:31806676 A PXY-Mediated Transcriptional Network Integrates Signaling ... | ACCEPT | Summary: Evidence from vascular development signaling network study. Reason: While this study focuses on vascular development rather than HSFA2's primary heat stress role, the molecular function "transcription cis-regulatory region binding" accurately describes HSFA2's core activity as a transcription factor. The annotation is correct even if identified in a different biological context. Supporting Evidence: PMID:31806676 A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. |
| GO:0071456 cellular response to hypoxia | HEP PMID:31519798 Integrative Analysis from the Epigenome to Translatome Uncov... | KEEP AS NON CORE | Summary: High-throughput expression profiling showing HSFA2 responsive to hypoxia. Reason: HSFA2 is indeed induced by hypoxia/anoxia and contributes to anoxia tolerance [PMID:20089772]. However, hypoxia response is NOT HSFA2's primary function - it's a secondary stress response that overlaps mechanistically with heat stress. The core function remains heat stress memory and acquired thermotolerance. Marking NON-CORE. Supporting Evidence: PMID:31519798 Sep 13. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. PMID:20089772 Among the transcription factors induced by both heat and anoxia, the heat shock factor A2 (HsfA2), known to be involved in Arabidopsis acclimation to heat and to other abiotic stresses, was strongly induced by anoxia. |
| GO:0005634 nucleus | ISM GO_REF:0000122 | ACCEPT | Summary: Computational prediction of nuclear localization from AtSubP analysis. Reason: Consistent with experimental evidence. HSFA2 is indeed nuclear. Third independent annotation for nucleus - all consistent. |
| GO:0005515 protein binding | IPI PMID:20388662 Cytosol-localized heat shock factor-binding protein, AtHSBP,... | KEEP AS NON CORE | Summary: Physical interaction with HSBP (heat shock factor binding protein). Reason: The physical interaction with HSBP is real, but the available GO term is the generic protein binding term and no precise HSBP-binding term is available here. This should not be treated as a core molecular function; HSFA2's core activity is DNA binding and transcriptional activation in heat-acclimation programs. Supporting Evidence: PMID:20388662 Apr 13. Cytosol-localized heat shock factor-binding protein, AtHSBP, functions as a negative regulator of heat shock response by translocation to the nucleus and is required for seed development in Arabidopsis. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:19352026 Analysis of the regulation of target genes by an Arabidopsis... | ACCEPT | Summary: Direct assay evidence from target gene regulation analysis showing HSFA2 activates HSP and stress response genes. Reason: PMID:19352026 demonstrates HSFA2 activates target genes like Hsp18.1-CI, GolS1, and Bag6 through binding to TATA-proximal HSEs. CORE transcriptional activation function. Supporting Evidence: PMID:19352026 Epub 2009 Apr 7. Analysis of the regulation of target genes by an Arabidopsis heat shock transcription factor, HsfA2. |
| GO:0071456 cellular response to hypoxia | IEP PMID:21398256 The AP2/ERF transcription factor AtERF73/HRE1 modulates ethy... | KEEP AS NON CORE | Summary: Expression pattern evidence from ERF73/HRE1 hypoxia study. Reason: HSFA2 expression is modulated during hypoxia [PMID:20089772] but hypoxia response is NOT the primary function. Marking NON-CORE as this is secondary to heat stress memory function. Supporting Evidence: PMID:21398256 Mar 10. The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis. |
| GO:0005515 protein binding | IPI PMID:20521085 Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modi... | KEEP AS NON CORE | Summary: Physical interaction with SUMO1 for sumoylation. Reason: The physical interaction with SUMO1 is real, but generic protein binding is not a core HSFA2 molecular function. The biologically informative finding from PMID:20521085 is covalent SUMOylation of HSFA2 at Lys-315, so that process is represented below as a separate NEW biological-process annotation rather than as a cross-aspect replacement for this MF binding row. Supporting Evidence: PMID:20521085 Further investigation allowed us to determine that Lys 315 of AtHsfA2 is the main SUMOylation site. |
| GO:0016925 protein sumoylation | IDA PMID:20521085 Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modi... | NEW | Summary: HSFA2 is covalently SUMOylated at Lys-315, and this post-translational modification modulates HSFA2 transcriptional activity during acquired thermotolerance. Reason: The existing IPI protein-binding annotation captures the SUMO1 physical interaction only generically. PMID:20521085 directly supports SUMOylation of HSFA2 at Lys-315 and links AtSUMO1 to reduced HSFA2 activation of heat-shock promoters, making protein sumoylation the specific biological-process annotation warranted by this evidence. Supporting Evidence: PMID:20521085 In this work we show SUMOylation of the heat shock transcription factor, AtHsfA2, in connection with the plant's response to heat stress and acquired thermotolerance. PMID:20521085 Further investigation allowed us to determine that Lys 315 of AtHsfA2 is the main SUMOylation site. |
| GO:0005634 nucleus | IDA PMID:20521085 Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modi... | ACCEPT | Summary: Direct microscopy/localization evidence from sumoylation study. Reason: Strong experimental evidence (IDA) for nuclear localization. Consistent with other annotations. CORE cellular component. Supporting Evidence: |
| GO:0010286 heat acclimation | IMP PMID:20521085 Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modi... | ACCEPT | Summary: Mutant phenotype evidence from sumoylation study showing hsfa2 has heat-sensitive phenotype in acquired thermotolerance. Reason: Excellent annotation. PMID:20521085 shows hsfa2 mutants have impaired acquired thermotolerance, directly demonstrating HSFA2's CORE role in heat acclimation. This is PRIMARY CORE FUNCTION. Supporting Evidence: PMID:20521085 The phenotype of seedlings overexpressing AtSUMO1 resembled the phenotype of AtHsfA2 knock out seedlings, which were more sensitive than wild type seedlings to repeated heat treatment. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:20521085 Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modi... | ACCEPT | Summary: Direct assay showing HSFA2 activates transcription, with sumoylation modulating this activity. Reason: CORE transcriptional activation function confirmed by direct assay. Supporting Evidence: PMID:20521085 Overexpression of AtSUMO1 led to a decrease in AtHsfA2 transcriptional activation of heat shock promoters. |
| GO:0001666 response to hypoxia | IMP PMID:20089772 The heat-inducible transcription factor HsfA2 enhances anoxi... | KEEP AS NON CORE | Summary: Mutant phenotype evidence showing HSFA2 contributes to anoxia tolerance, particularly heat-dependent acclimation to anoxia. Reason: PMID:20089772 shows hsfa2 mutants lose heat-dependent acclimation to anoxia, and HSFA2 overexpression enhances anoxia tolerance. However, this is NOT HSFA2's primary function - it reflects mechanistic overlap between heat and anoxia stress responses through shared HSP targets. The paper explicitly states "considerable overlap between the molecular mechanisms of heat and anoxia tolerance." Marking NON-CORE. Supporting Evidence: PMID:20089772 Heat-dependent acclimation to anoxia is lost in an HsfA2 knockout mutant (hsfa2) |
| GO:0009408 response to heat | IEP PMID:20089772 The heat-inducible transcription factor HsfA2 enhances anoxi... | KEEP AS NON CORE | Summary: Expression pattern showing HSFA2 induced by heat in the anoxia tolerance study. Reason: Duplicate of earlier GO:0009408 annotation. HSFA2 is heat-induced but this general term doesn't capture the MEMORY/ACQUIRED aspect of HSFA2's specific role. NON-CORE as it conflates with HSFA1's immediate response role. Supporting Evidence: PMID:20089772 A significant overlap between the anoxic and the heat responses was observed by whole-genome microarray analysis. |
| GO:0034605 cellular response to heat | IEP PMID:20089772 The heat-inducible transcription factor HsfA2 enhances anoxi... | KEEP AS NON CORE | Summary: Expression profiling showing HSFA2 responds to heat at cellular level. This is a broad, valid heat-response annotation rather than the specific thermomemory/acclimation process. Reason: PMID:20089772 supports heat-inducible HSFA2 expression in anoxia and oxidative-stress contexts. That evidence is sufficient to retain the broad cellular response to heat annotation, but not to replace this entry with the more specific heat acclimation term. Supporting Evidence: PMID:20089772 A significant overlap between the anoxic and the heat responses was observed by whole-genome microarray analysis. |
| GO:0042542 response to hydrogen peroxide | IEP PMID:20089772 The heat-inducible transcription factor HsfA2 enhances anoxi... | KEEP AS NON CORE | Summary: HSFA2 is induced by H2O2 which triggers its activation under anoxia. Reason: PMID:20089772 shows H2O2 produced at onset of anoxia induces HSFA2, and H2O2 treatment confers anoxia tolerance. HSFA2 is indeed H2O2-responsive [deep-research], but this is NOT the core function. It's a regulatory input signal. Marking NON-CORE. Supporting Evidence: PMID:20089772 Exogenous H 2 O 2 treatment induces HsfA2 and confers anoxia tolerance |
| GO:0034620 cellular response to unfolded protein | IEP PMID:19244141 The cytosolic protein response as a subcomponent of the wide... | KEEP AS NON CORE | Summary: Expression pattern evidence from cytosolic unfolded protein response study. Reason: HSFA2 responds to unfolded protein stress as part of its general role in proteostasis through HSP induction. However, this is downstream of its primary heat stress memory function. The unfolded protein response is a consequence/component of heat stress, not HSFA2's defining feature. NON-CORE. Supporting Evidence: PMID:19244141 The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis. |
| GO:0034620 cellular response to unfolded protein | IMP PMID:19244141 The cytosolic protein response as a subcomponent of the wide... | KEEP AS NON CORE | Summary: Mutant phenotype evidence for role in unfolded protein response. Reason: Same as IEP annotation above - this is a component of the broader heat stress response but not HSFA2's defining core function. NON-CORE. Supporting Evidence: PMID:19244141 The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis. |
| GO:0009408 response to heat | IEP PMID:15247379 Role of Hsp17.4-CII as coregulator and cytoplasmic retention... | KEEP AS NON CORE | Summary: Expression pattern evidence from tomato HsfA2 study (ortholog). Reason: Cross-species evidence from tomato. Third instance of GO:0009408. Same issue - too general to capture HSFA2's specific MEMORY role. NON-CORE. Supporting Evidence: PMID:15247379 Jul 9. Role of Hsp17.4-CII as coregulator and cytoplasmic retention factor of tomato heat stress transcription factor HsfA2. |
| GO:0003700 DNA-binding transcription factor activity | ISS PMID:11118137 Arabidopsis transcription factors: genome-wide comparative a... | ACCEPT | Summary: Sequence similarity evidence from genome-wide transcription factor analysis. Reason: ISS (inferred from sequence similarity) annotation based on conserved HSF domain. Consistent with all other TF activity annotations. CORE molecular function. Supporting Evidence: PMID:11118137 Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. |
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