BAK1/SERK3 is an Arabidopsis plasma-membrane leucine-rich repeat receptor-like kinase that acts mainly as a co-receptor kinase. It forms ligand-induced receptor complexes with brassinosteroid receptor BRI1 and multiple pattern-recognition receptors such as FLS2/EFR/CERK-related immune complexes, then contributes kinase activity and scaffold/co-receptor functions needed for brassinosteroid signaling, pattern-triggered immunity, receptor complex phosphorylation, endocytosis, and signaling attenuation. BAK1 also participates in cell-death regulation, but broad pathogen-defense phenotypes are downstream outputs of its receptor-complex role rather than separate core functions.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0140426 pathogen-associated molecular pattern receptor signaling pathway | IMP PMID:17626179 The receptor-like kinase SERK3/BAK1 is a central regulator o... | NEW | Summary: BAK1/SERK3 functions as a co-receptor kinase in FLS2/EFR/CERK-family pattern-recognition receptor complexes. Reason: PMID:17626179 shows that loss of SERK3/BAK1 reduces early flg22-dependent responses and that BAK1 rapidly enters a ligand-dependent complex with FLS2, directly supporting IMP curation to the PAMP receptor signaling pathway. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. PMID:17626179 AtSERK3/BAK1 rapidly enters an elicitor-dependent complex with FLAGELLIN SENSING 2 (FLS2), the receptor for the bacterial PAMP flagellin and its peptide derivative flg22. |
| GO:0002229 defense response to oomycetes | IMP PMID:17583510 The BRI1-associated kinase 1, BAK1, has a brassinolide-indep... | KEEP AS NON CORE | Summary: BAK1 contributes to defense response to oomycetes through pattern-recognition receptor and cell-death signaling complexes. Reason: The phenotype/process is supported as a downstream immune output, but BAK1's core role is receptor-like kinase co-receptor signaling rather than being a pathogen-response effector itself. |
| GO:0009626 plant-type hypersensitive response | IMP PMID:18667726 Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE proteins s... | KEEP AS NON CORE | Summary: BAK1 contributes to plant-type hypersensitive response through pattern-recognition receptor and cell-death signaling complexes. Reason: The phenotype/process is supported as a downstream immune output, but BAK1's core role is receptor-like kinase co-receptor signaling rather than being a pathogen-response effector itself. |
| GO:0009742 brassinosteroid mediated signaling pathway | IMP PMID:18667726 Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE proteins s... | ACCEPT | Summary: BAK1/SERK3 is a BRI1-associated co-receptor kinase required for normal brassinosteroid signaling outputs. Reason: Brassinosteroid receptor-complex signaling is one of the two best-supported core biological roles of BAK1. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0009742 brassinosteroid mediated signaling pathway | IGI PMID:22253607 Genetic evidence for an indispensable role of somatic embryo... | ACCEPT | Summary: BAK1/SERK3 is a BRI1-associated co-receptor kinase required for normal brassinosteroid signaling outputs. Reason: Brassinosteroid receptor-complex signaling is one of the two best-supported core biological roles of BAK1. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0042742 defense response to bacterium | IMP PMID:17583510 The BRI1-associated kinase 1, BAK1, has a brassinolide-indep... | KEEP AS NON CORE | Summary: BAK1 contributes to defense response to bacterium through pattern-recognition receptor and cell-death signaling complexes. Reason: The phenotype/process is supported as a downstream immune output, but BAK1's core role is receptor-like kinase co-receptor signaling rather than being a pathogen-response effector itself. |
| GO:0050832 defense response to fungus | IMP PMID:17583510 The BRI1-associated kinase 1, BAK1, has a brassinolide-indep... | KEEP AS NON CORE | Summary: BAK1 contributes to defense response to fungus through pattern-recognition receptor and cell-death signaling complexes. Reason: The phenotype/process is supported as a downstream immune output, but BAK1's core role is receptor-like kinase co-receptor signaling rather than being a pathogen-response effector itself. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but protein kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0004672 protein kinase activity | IDA PMID:21680842 Direct ubiquitination of pattern recognition receptor FLS2 a... | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but protein kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000003 | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but protein serine/threonine kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:12150929 BAK1, an Arabidopsis LRR receptor-like protein kinase, inter... | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but protein serine/threonine kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000116 | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but protein tyrosine kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0004714 transmembrane receptor protein tyrosine kinase activity | IEA GO_REF:0000003 | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but transmembrane receptor protein tyrosine kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005102 signaling receptor binding | IPI PMID:26320950 Differential Function of Arabidopsis SERK Family Receptor-li... | ACCEPT | Summary: BAK1 binds ligand-activated receptors such as BIR-regulated LRR-RLK complexes as a signaling co-receptor. Reason: Signaling receptor binding is a specific molecular role for BAK1 as an LRR-RLK co-receptor. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:12150928 BRI1/BAK1, a receptor kinase pair mediating brassinosteroid ... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:12150929 BAK1, an Arabidopsis LRR receptor-like protein kinase, inter... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:15548744 Heterodimerization and endocytosis of Arabidopsis brassinost... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:16473966 The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 ... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:16857903 Brassinosteroids regulate dissociation of BKI1, a negative r... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:17625569 A flagellin-induced complex of the receptor FLS2 and BAK1 in... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:17626179 The receptor-like kinase SERK3/BAK1 is a central regulator o... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:19452453 Proteomic profiling of tandem affinity purified 14-3-3 prote... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:19532123 Membrane steroid-binding protein 1 (MSBP1) negatively regula... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:19616764 Regulation of cell death and innate immunity by two receptor... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:20018686 A receptor-like cytoplasmic kinase, BIK1, associates with a ... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:21499263 Stem-cell-triggered immunity through CLV3p-FLS2 signalling. | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:22087006 Brassinosteroids inhibit pathogen-associated molecular patte... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:22184234 Deactivation of the Arabidopsis BRASSINOSTEROID INSENSITIVE ... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:24114786 Structural basis for flg22-induced activation of the Arabido... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:24388849 The leucine-rich repeat receptor kinase BIR2 is a negative r... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:24556575 Structure of the pseudokinase domain of BIR2, a regulator of... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:24625928 A bacterial tyrosine phosphatase inhibits plant pattern reco... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:26308901 Allosteric receptor activation by the plant peptide hormone ... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:27229311 Signature motif-guided identification of receptors for pepti... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:27317676 The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for B... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:29320478 An extracellular network of Arabidopsis leucine-rich repeat ... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:30806640 Map of physical interactions between extracellular domains o... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:32327536 STRESS INDUCED FACTOR 2 Regulates Arabidopsis Stomatal Immun... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:33514716 Perception of a divergent family of phytocytokines by the Ar... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005515 protein binding | IPI PMID:35087541 The Phloem Intercalated With Xylem-Correlated 3 Receptor-Lik... | MARK AS OVER ANNOTATED | Summary: The cited study reports a BAK1 interaction in brassinosteroid or immune receptor-complex context. Reason: Generic protein binding is true but not informative for BAK1; the biologically useful curation is receptor kinase/co-receptor complex binding and signaling. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: ATP binding is expected for the BAK1 kinase domain. Reason: This is compatible with kinase activity but less informative than receptor Ser/Thr kinase activity. |
| GO:0033612 receptor serine/threonine kinase binding | IPI PMID:19616764 Regulation of cell death and innate immunity by two receptor... | ACCEPT | Summary: BAK1 physically associates with receptor serine/threonine kinases in immune and growth signaling receptor complexes. Reason: This specific binding term captures BAK1 co-receptor complex assembly better than generic protein binding. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. PMID:19616764 Upon recognition of bacterial flagellin, the plant receptor FLS2 heterodimerizes with brassinosteroid insensitive 1-associated receptor kinase 1 (BAK1). |
| GO:0033612 receptor serine/threonine kinase binding | IPI PMID:26320950 Differential Function of Arabidopsis SERK Family Receptor-li... | ACCEPT | Summary: BAK1 physically associates with receptor serine/threonine kinases in immune and growth signaling receptor complexes. Reason: This specific binding term captures BAK1 co-receptor complex assembly better than generic protein binding. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. PMID:26320950 BAK1 could co-immunoprecipitate both ER and ERL1 when expressed under the control of their native promoters in transgenic Arabidopsis plants, indicating that they associate in vivo. |
| GO:0042802 identical protein binding | IPI PMID:20018686 A receptor-like cytoplasmic kinase, BIK1, associates with a ... | MARK AS OVER ANNOTATED | Summary: High-throughput or interaction evidence suggests BAK1 self-association or same-protein network context. Reason: Identical protein binding is not the informative molecular function for BAK1 and should not be treated as a core annotation. |
| GO:0042802 identical protein binding | IPI PMID:29320478 An extracellular network of Arabidopsis leucine-rich repeat ... | MARK AS OVER ANNOTATED | Summary: High-throughput or interaction evidence suggests BAK1 self-association or same-protein network context. Reason: Identical protein binding is not the informative molecular function for BAK1 and should not be treated as a core annotation. |
| GO:0046982 protein heterodimerization activity | IPI PMID:15548744 Heterodimerization and endocytosis of Arabidopsis brassinost... | ACCEPT | Summary: BAK1 forms heteromeric receptor complexes with BRI1/FLS2-family receptors after ligand perception. Reason: Protein heterodimerization is a supported molecular feature of BAK1 receptor complex formation. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. PMID:15548744 BRI1 and AtSERK3 preferentially heterodimerize in the endosomes. |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | MODIFY | Summary: BAK1 has catalytic activity as a membrane receptor-like Ser/Thr kinase, but protein serine kinase activity is less precise for this protein. Reason: The transmembrane receptor protein serine/threonine kinase activity term captures both the catalytic activity and receptor-like membrane context. Proposed replacements: transmembrane receptor protein serine/threonine kinase activity Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005768 endosome | IDA PMID:15548744 Heterodimerization and endocytosis of Arabidopsis brassinost... | KEEP AS NON CORE | Summary: BAK1 receptor complexes can undergo endocytic trafficking after signaling activation. Reason: Endosome/endosome membrane localization is a supported trafficking state but secondary to the plasma membrane co-receptor role. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | ISM GO_REF:0000122 | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | IDA PMID:12150928 BRI1/BAK1, a receptor kinase pair mediating brassinosteroid ... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | EXP PMID:12150929 BAK1, an Arabidopsis LRR receptor-like protein kinase, inter... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | HDA PMID:14506206 Large-scale analysis of in vivo phosphorylated membrane prot... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | EXP PMID:15548744 Heterodimerization and endocytosis of Arabidopsis brassinost... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | HDA PMID:17644812 A high content in lipid-modified peripheral proteins and int... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | IDA PMID:18182375 Proteomics studies of brassinosteroid signal transduction us... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | IDA PMID:19616764 Regulation of cell death and innate immunity by two receptor... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | EXP PMID:26071421 Phytosulfokine Regulates Growth in Arabidopsis through a Res... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0005886 plasma membrane | HDA PMID:28887381 Global Analysis of Membrane-associated Protein Oligomerizati... | ACCEPT | Summary: BAK1 is a single-pass plasma-membrane receptor-like kinase/co-receptor. Reason: Plasma membrane localization is central to BAK1 function in cell-surface receptor complexes. Supporting Evidence: file:ARATH/BAK1/BAK1-deep-research-falcon.md Falcon report summarizes BAK1/SERK3 as an LRR receptor-like kinase co-receptor for brassinosteroid and immune receptor complexes. |
| GO:0010008 endosome membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: BAK1 receptor complexes can undergo endocytic trafficking after signaling activation. Reason: Endosome/endosome membrane localization is a supported trafficking state but secondary to the plasma membrane co-receptor role. |
| GO:0010008 endosome membrane | EXP PMID:15548744 Heterodimerization and endocytosis of Arabidopsis brassinost... | KEEP AS NON CORE | Summary: BAK1 receptor complexes can undergo endocytic trafficking after signaling activation. Reason: Endosome/endosome membrane localization is a supported trafficking state but secondary to the plasma membrane co-receptor role. |
| GO:0032991 protein-containing complex | IPI PMID:16473966 The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 ... | KEEP AS NON CORE | Summary: BAK1 participates in protein-containing receptor complexes with BRI1, FLS2/EFR/CERK-related receptors, and regulatory partners. Reason: The generic complex term is directionally correct but less informative than specific receptor kinase/co-receptor complex annotations. |
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Download this section (compressed HTML)Q: Which BAK1 protein-binding annotations should be replaced by more specific GO terms for receptor kinase/co-receptor complex assembly?
Q: Which immune and brassinosteroid receptor complexes require BAK1 catalytic activity versus scaffold/co-receptor binding only?
Experiment: Compare ligand-induced phosphoproteomes in native BAK1, kinase-dead BAK1, and receptor-specific mutant backgrounds after brassinolide and flg22 treatments.
Hypothesis: BAK1 catalytic activity produces receptor-complex-specific phosphorylation signatures in brassinosteroid and PAMP signaling.
Type: phosphoproteomics
Experiment: Use endogenous tagged BAK1 affinity purification under ligand-specific treatments followed by quantitative MS and targeted validation of receptor/RLCK partners.
Hypothesis: Different BAK1 receptor-complex partners explain the diverse generic protein-binding annotations.
Type: interaction specificity
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