GIP1

UniProt ID: Q9M0N8
Organism: Arabidopsis thaliana
Review Status: DRAFT
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Gene Description

TODO: Add description for GIP1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0000930 gamma-tubulin complex
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: gamma-tubulin complex is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005819 spindle
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: spindle is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0031021 interphase microtubule organizing center
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: interphase microtubule organizing center is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051415 microtubule nucleation by interphase microtubule organizing center
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: microtubule nucleation by interphase microtubule organizing center is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0090307 mitotic spindle assembly
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: mitotic spindle assembly is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0000931 gamma-tubulin ring complex
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: gamma-tubulin ring complex is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005634 nucleus
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005635 nuclear envelope
IEA
GO_REF:0000044 		KEEP AS NON CORE
Summary: Manual review: nuclear envelope may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005815 microtubule organizing center
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: microtubule organizing center is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005819 spindle
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: spindle is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005874 microtubule
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: microtubule is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009524 phragmoplast
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: phragmoplast is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0033566 gamma-tubulin complex localization
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: gamma-tubulin complex localization is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005515 protein binding
IPI
PMID:18178112
Identification of a novel small Arabidopsis protein interact... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GIP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005739 mitochondrion
ISM
GO_REF:0000122 		REMOVE
Summary: Manual review: mitochondrion is not sufficiently supported as a direct function of GIP1.
Reason: Removed due weak mechanistic support or likely misannotation for this gene.
GO:0000776 kinetochore
IDA
PMID:26124146
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for ce... 		KEEP AS NON CORE
Summary: Manual review: kinetochore may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005635 nuclear envelope
IDA
PMID:26124146
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for ce... 		KEEP AS NON CORE
Summary: Manual review: nuclear envelope may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005640 nuclear outer membrane
IDA
PMID:26124146
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for ce... 		KEEP AS NON CORE
Summary: Manual review: nuclear outer membrane may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0034080 CENP-A containing chromatin assembly
IGI
PMID:26124146
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for ce... 		KEEP AS NON CORE
Summary: Manual review: CENP-A containing chromatin assembly may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0042393 histone binding
IPI
PMID:26124146
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for ce... 		KEEP AS NON CORE
Summary: Manual review: histone binding may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005515 protein binding
IPI
PMID:22404201
Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integr... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GIP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005515 protein binding
IPI
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for GIP1.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0000226 microtubule cytoskeleton organization
IMP
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		KEEP AS NON CORE
Summary: Manual review: microtubule cytoskeleton organization may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0000930 gamma-tubulin complex
IDA
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		ACCEPT
Summary: Manual review: gamma-tubulin complex is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005635 nuclear envelope
IDA
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		KEEP AS NON CORE
Summary: Manual review: nuclear envelope may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005828 kinetochore microtubule
IDA
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		KEEP AS NON CORE
Summary: Manual review: kinetochore microtubule may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0007052 mitotic spindle organization
IMP
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		ACCEPT
Summary: Manual review: mitotic spindle organization is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009524 phragmoplast
IDA
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		ACCEPT
Summary: Manual review: phragmoplast is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009574 preprophase band
IDA
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		KEEP AS NON CORE
Summary: Manual review: preprophase band may be context-dependent or peripheral for GIP1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0072686 mitotic spindle
IDA
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for... 		ACCEPT
Summary: Manual review: mitotic spindle is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051418 microtubule nucleation by microtubule organizing center
IDA
PMID:22404201
Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integr... 		ACCEPT
Summary: Manual review: microtubule nucleation by microtubule organizing center is consistent with known biology of GIP1.
Reason: Retained as supported or plausible for this gene and evidence context.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000122
AtSubP analysis
PMID:18178112
Identification of a novel small Arabidopsis protein interacting with gamma-tubulin complex protein 3.
PMID:22404201
Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex.
PMID:22427335
The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability.
PMID:26124146
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture.

📄 View Raw YAML

 
id: Q9M0N8
gene_symbol: GIP1
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:3702
  label: Arabidopsis thaliana
description: 'TODO: Add description for GIP1'
existing_annotations:
- term:
    id: GO:0000930
    label: gamma-tubulin complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: gamma-tubulin complex is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: spindle is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0031021
    label: interphase microtubule organizing center
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: interphase microtubule organizing center is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051415
    label: microtubule nucleation by interphase microtubule organizing center
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: microtubule nucleation by interphase microtubule organizing center is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0090307
    label: mitotic spindle assembly
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: mitotic spindle assembly is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0000931
    label: gamma-tubulin ring complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: gamma-tubulin ring complex is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005635
    label: nuclear envelope
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: nuclear envelope may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005815
    label: microtubule organizing center
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: microtubule organizing center is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: spindle is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005874
    label: microtubule
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: microtubule is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009524
    label: phragmoplast
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: phragmoplast is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0033566
    label: gamma-tubulin complex localization
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: gamma-tubulin complex localization is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18178112
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GIP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: ISM
  original_reference_id: GO_REF:0000122
  review:
    summary: 'Manual review: mitochondrion is not sufficiently supported as a direct function of GIP1.'
    action: REMOVE
    reason: Removed due weak mechanistic support or likely misannotation for this gene.
- term:
    id: GO:0000776
    label: kinetochore
  evidence_type: IDA
  original_reference_id: PMID:26124146
  review:
    summary: 'Manual review: kinetochore may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005635
    label: nuclear envelope
  evidence_type: IDA
  original_reference_id: PMID:26124146
  review:
    summary: 'Manual review: nuclear envelope may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005640
    label: nuclear outer membrane
  evidence_type: IDA
  original_reference_id: PMID:26124146
  review:
    summary: 'Manual review: nuclear outer membrane may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0034080
    label: CENP-A containing chromatin assembly
  evidence_type: IGI
  original_reference_id: PMID:26124146
  review:
    summary: 'Manual review: CENP-A containing chromatin assembly may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0042393
    label: histone binding
  evidence_type: IPI
  original_reference_id: PMID:26124146
  review:
    summary: 'Manual review: histone binding may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22404201
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GIP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for GIP1.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0000226
    label: microtubule cytoskeleton organization
  evidence_type: IMP
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: microtubule cytoskeleton organization may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0000930
    label: gamma-tubulin complex
  evidence_type: IDA
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: gamma-tubulin complex is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005635
    label: nuclear envelope
  evidence_type: IDA
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: nuclear envelope may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005828
    label: kinetochore microtubule
  evidence_type: IDA
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: kinetochore microtubule may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0007052
    label: mitotic spindle organization
  evidence_type: IMP
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: mitotic spindle organization is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009524
    label: phragmoplast
  evidence_type: IDA
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: phragmoplast is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009574
    label: preprophase band
  evidence_type: IDA
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: preprophase band may be context-dependent or peripheral for GIP1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0072686
    label: mitotic spindle
  evidence_type: IDA
  original_reference_id: PMID:22427335
  review:
    summary: 'Manual review: mitotic spindle is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051418
    label: microtubule nucleation by microtubule organizing center
  evidence_type: IDA
  original_reference_id: PMID:22404201
  review:
    summary: 'Manual review: microtubule nucleation by microtubule organizing center is consistent with known biology of GIP1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000122
  title: AtSubP analysis
  findings: []
- id: PMID:18178112
  title: Identification of a novel small Arabidopsis protein interacting with gamma-tubulin complex protein 3.
  findings: []
- id: PMID:22404201
  title: Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex.
  findings: []
- id: PMID:22427335
  title: The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability.
  findings: []
- id: PMID:26124146
  title: Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture.
  findings: []