IAA17 (AUXIN RESISTANT 3, AXR3; At1g04250) is an Aux/IAA transcriptional repressor of auxin-responsive genes. Like other canonical Aux/IAAs it is a short-lived nuclear protein with an EAR-motif domain I that recruits TOPLESS-family co-repressors, a domain II degron recognized by the SCF(TIR1/AFB) auxin receptors in an auxin-dependent manner, and a C-terminal PB1 domain that mediates homo-oligomerization and heterodimerization with AUXIN RESPONSE FACTORs, including the activators ARF5, ARF7 and ARF19. At low auxin IAA17 represses ARF-dependent transcription; auxin promotes SCF(TIR1)-dependent ubiquitination and proteasomal degradation of IAA17 (half-life of minutes), releasing ARFs. The semidominant axr3-1 mutation in domain II stabilizes the protein and causes pleiotropic auxin-related phenotypes including altered root growth, root hair and gravitropic defects, and increased apical dominance. IAA17 is itself rapidly induced by auxin, forming part of the negative feedback in the pathway.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000976 transcription cis-regulatory region binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Regulatory-DNA association is retained with yeast one-hybrid and phylogenetic scope limits. Reason: Publisher Supplementary Table 2 of PMID:25533953 contains the exact IAA12/AT1G04550–AT5G12870 (MYB46 promoter) positive (Sheet1 row445; reproduced in IAA12-source-analysis). Table5 confirms the AUX-IAA clone, and the Methods report repeated screens and sequence confirmation. This is heterologous yeast one-hybrid evidence for regulatory-DNA association, not a demonstrated endogenous MYB46 regulatory function or purified-protein DNA-contact mechanism. The previous explanation that an ARF must tether IAA12 in this assay was not demonstrated and is withdrawn. Absence of a recognized sequence-specific DNA-binding domain does not by itself negate the positive assay. For IAA17, retain the PAINT inherited-node judgment as non-core; the reviewed IAA12 experiment is a family experimental anchor, not a new direct assay on IAA17. No target-specific loss or defective ancestral-node placement has been established. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN001272225 SUPPORTS TRANSFER PAINT ancestral assertion retained; lack of a conventional DNA-binding domain alone is not evidence of lineage-specific loss. Native DNA-contact mechanism remains unresolved. Supporting Evidence: PMID:25533953 All interacting transcription factors were assembled into a cell wall interaction library and the screen was repeated to confirm the results and each clone was sequenced to reconfirm identity. file:ARATH/IAA12/IAA12-source-analysis/README.md PMID:25533953 publisher Supplementary Table 2, Sheet1, row 445 contains transcription factor AT1G04550 (IAA12), promoter AT5G12870 (MYB46), expression fields `ppp, x`, and one reporter activated. |
| GO:0003700 DNA-binding transcription factor activity | ISS PMID:11118137 Arabidopsis transcription factors: genome-wide comparative a... | MODIFY | Summary: Refine the historical transcription-factor classification to corepressor activity. Reason: PMID:11118137 is a genome-wide regulator classification, not a IAA17-specific DNA-binding/transactivation assay. The specific functional evidence supports repression through ARF association. Refine to transcription corepressor activity. The separately retained promoter-association term does not by itself establish an autonomous DNA-binding transcription-factor activity. Proposed replacements: transcription corepressor activity Supporting Evidence: PMID:14742873 GD-IAA17[I/mII] PMID:14742873 causing nearly complete repression in an auxin-independent manner |
| GO:0005515 protein binding | IPI PMID:11713520 Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA p... | MODIFY | Summary: Refine binding to the experimentally grounded regulatory partner class (UniProtKB:Q570C0). Reason: PMID:11713520 supplies this partner-specific interaction assertion; independent gene-specific ARF7/ARF5 or SCF experiments ground the functional partner class for IAA17. The specific molecular interaction is more informative than bare protein binding. Preserve assay scope: yeast/protoplast/pull-down interaction does not establish every tissue-specific transcriptional target, a fixed complex stoichiometry, or sufficiency for the whole auxin response. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:11713520 SCF(TIR1) interacts with AXR2/IAA7 and AXR3/IAA17 |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24407 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:O24407. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24408 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:O24408. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24409 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:O24409. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24410 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:O24410. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P33077 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:P33077. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P33078 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:P33078. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49677 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:P49677. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49678 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:P49678. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38822 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38822. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38824 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38824. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38826 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38826. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38827 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38827. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38828 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38828. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38830 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38830. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38831 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38831. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38832 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q38832. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8H174 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q8H174. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8LAL2 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q8LAL2. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | MODIFY | Summary: Refine the curated IAA17–ARF19 interaction to DNA-binding transcription factor binding. Reason: The original network interaction identifies ARF19. Independent curated UniProt CC:INTERACTION explicitly records this same pair, while the primary Aux/IAA–ARF study supports the regulatory interaction class. ARF19 is a DNA-binding transcription factor, so the specific molecular binding term is justified without asserting a particular downstream developmental program or obligatory native stoichiometry. The original paper/reference and partner payload are unchanged. Proposed replacements: DNA-binding transcription factor binding Supporting Evidence: file:ARATH/IAA17/IAA17-uniprot.txt P93830; Q8RYC8: ARF19; NbExp=6; IntAct=EBI-632243, EBI-529887; PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C5W9 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q9C5W9. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C5X0 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q9C5X0. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9XED8 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q9XED8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9XFM0 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q9XFM0. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9ZSY8 interaction record. Reason: PMID:21734647 is the systematic Aux/IAA–ARF yeast two-hybrid network, with selected BiFC validations. This row identifies UniProtKB:Q9ZSY8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:26611158 Germostatin resistance locus 1 encodes a PHD finger protein ... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–AGI_LocusCode:AT1G04250 interaction record. Reason: PMID:26611158 is the GSR1/ARF16/IAA17 biochemical interaction study in the seed-germination context. This row identifies AGI_LocusCode:AT1G04250. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:26611158 attenuates the intensity of interaction of IAA17/ARF16 by directly interacting with IAA17 to release ARF16 |
| GO:0005515 protein binding | IPI PMID:26611158 Germostatin resistance locus 1 encodes a PHD finger protein ... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–AGI_LocusCode:AT3G27490 interaction record. Reason: PMID:26611158 is the GSR1/ARF16/IAA17 biochemical interaction study in the seed-germination context. This row identifies AGI_LocusCode:AT3G27490. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:26611158 attenuates the intensity of interaction of IAA17/ARF16 by directly interacting with IAA17 to release ARF16 |
| GO:0005515 protein binding | IPI PMID:26611158 Germostatin resistance locus 1 encodes a PHD finger protein ... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–AGI_LocusCode:AT4G30080 interaction record. Reason: PMID:26611158 is the GSR1/ARF16/IAA17 biochemical interaction study in the seed-germination context. This row identifies AGI_LocusCode:AT4G30080. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:26611158 attenuates the intensity of interaction of IAA17/ARF16 by directly interacting with IAA17 to release ARF16 |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24407 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:O24407. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24409 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:O24409. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O64647 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:O64647. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P33077 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:P33077. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P33078 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:P33078. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49677 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:P49677. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49678 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:P49678. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38822 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q38822. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38824 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q38824. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38826 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q38826. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38828 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q38828. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38829 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q38829. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38831 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q38831. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q5XEN5 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q5XEN5. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8H174 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q8H174. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8LAL2 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q8LAL2. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8LPR5 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q8LPR5. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8RYC6 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q8RYC6. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | MODIFY | Summary: Refine the curated IAA17–ARF19 interaction to DNA-binding transcription factor binding. Reason: The original network interaction identifies ARF19. Independent curated UniProt CC:INTERACTION explicitly records this same pair, while the primary Aux/IAA–ARF study supports the regulatory interaction class. ARF19 is a DNA-binding transcription factor, so the specific molecular binding term is justified without asserting a particular downstream developmental program or obligatory native stoichiometry. The original paper/reference and partner payload are unchanged. Proposed replacements: DNA-binding transcription factor binding Supporting Evidence: file:ARATH/IAA17/IAA17-uniprot.txt P93830; Q8RYC8: ARF19; NbExp=6; IntAct=EBI-632243, EBI-529887; PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C5W9 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9C5W9. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C5X0 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9C5X0. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C9L2 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9C9L2. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FKM7 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9FKM7. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9M1U4 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9M1U4. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9S7W5 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9S7W5. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9XED8 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9XED8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9XFM0 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9XFM0. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:28650476 CrY2H-seq: a massively multiplexed assay for deep-coverage i... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9ZSY8 interaction record. Reason: PMID:28650476 is the CrY2H-seq heterologous binary-interaction screen, not an endogenous complex or physiological-function assay. This row identifies UniProtKB:Q9ZSY8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:28650476 a network of 8,577 interactions among 1,453 transcription factors |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:A0A2H1ZEF6 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:A0A2H1ZEF6. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:C0SUW7 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:C0SUW7. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:F4JL11 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:F4JL11. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O04294 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O04294. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O22179 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O22179. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24407 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O24407. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24408 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O24408. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24409 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O24409. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O24410 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O24410. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:O80533 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:O80533. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P33077 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:P33077. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P33078 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:P33078. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49677 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:P49677. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49678 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:P49678. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38822 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38822. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38824 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38824. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38826 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38826. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38827 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38827. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38828 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38828. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38829 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38829. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38830 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38830. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38831 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38831. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q38832 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q38832. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q5XEN5 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q5XEN5. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8H174 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q8H174. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8LAJ7 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q8LAJ7. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8LAL2 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q8LAL2. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8RV83 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q8RV83. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8RYC6 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q8RYC6. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | MODIFY | Summary: Refine the curated IAA17–ARF19 interaction to DNA-binding transcription factor binding. Reason: The original network interaction identifies ARF19. Independent curated UniProt CC:INTERACTION explicitly records this same pair, while the primary Aux/IAA–ARF study supports the regulatory interaction class. ARF19 is a DNA-binding transcription factor, so the specific molecular binding term is justified without asserting a particular downstream developmental program or obligatory native stoichiometry. The original paper/reference and partner payload are unchanged. Proposed replacements: DNA-binding transcription factor binding Supporting Evidence: file:ARATH/IAA17/IAA17-uniprot.txt P93830; Q8RYC8: ARF19; NbExp=6; IntAct=EBI-632243, EBI-529887; PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q8VZS3 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q8VZS3. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q94JM3 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q94JM3. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C5W9 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9C5W9. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C5X0 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9C5X0. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C8Y3 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9C8Y3. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9C9L2 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9C9L2. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FIW5 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FIW5. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FK47 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FK47. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FKM7 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FKM7. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FPE8 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FPE8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FTA2 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FTA2. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FVU9 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FVU9. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9FWY7 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9FWY7. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9LQW3 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9LQW3. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9LSI4 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9LSI4. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9LTC4 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9LTC4. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9M1U4 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9M1U4. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9MAH8 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9MAH8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9S7W5 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9S7W5. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9XFM0 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9XFM0. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:Q9ZSY8 interaction record. Reason: PMID:32612234 is the phytohormone binary-interaction network; cached abstract describes the screen but not each pair-specific assay. This row identifies UniProtKB:Q9ZSY8. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions |
| GO:0005515 protein binding | IPI PMID:9342315 Protein-protein interactions among the Aux/IAA proteins. | REMOVE | Summary: Policy removal of bare protein binding; retain the IAA17–UniProtKB:P49677 interaction record. Reason: PMID:9342315 is the IAA1-bait Aux/IAA interaction and cDNA-cloning study. This row identifies UniProtKB:P49677. The measured interaction is not declared false. Bare GO:0005515 does not specify the regulatory function, so it is removed under the repository protein-binding exception. A physical interaction alone does not establish an endogenous obligatory complex, a partner-specific physiological output, or a new biological process. Pair provenance remains in this reason and the unchanged source fields. Supporting Evidence: PMID:9342315 Screening an Arabidopsis lambda-ACT cDNA library using IAA1 as a bait reveals heterotypic interactions of IAA1 with known and newly discovered members of the Arabidopsis Aux/IAA gene family |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Retain nuclear localization with the actual assay or inference scope. Reason: PMID:22912871 directly images IAA17-GFP as a nuclear positive control in Arabidopsis mesophyll protoplasts; PMID:11283339 independently tests nuclear accumulation. The IAA8-focused title does not exclude these IAA17 experiments. Retain nucleus without replacing it with a finer compartment. Supporting Evidence: PMID:22912871 IAA7-GFP and IAA17-GFP localized exclusively to the nucleus |
| GO:0005634 nucleus | IDA PMID:15994909 RAC GTPases in tobacco and Arabidopsis mediate auxin-induced... | ACCEPT | Summary: Retain nuclear localization with the actual assay or inference scope. Reason: PMID:22912871 directly images IAA17-GFP as a nuclear positive control in Arabidopsis mesophyll protoplasts; PMID:11283339 independently tests nuclear accumulation. The IAA8-focused title does not exclude these IAA17 experiments. Retain nucleus without replacing it with a finer compartment. Supporting Evidence: PMID:22912871 IAA7-GFP and IAA17-GFP localized exclusively to the nucleus |
| GO:0005634 nucleus | IDA PMID:22912871 IAA8 involved in lateral root formation interacts with the T... | ACCEPT | Summary: Retain nuclear localization with the actual assay or inference scope. Reason: PMID:22912871 directly images IAA17-GFP as a nuclear positive control in Arabidopsis mesophyll protoplasts; PMID:11283339 independently tests nuclear accumulation. The IAA8-focused title does not exclude these IAA17 experiments. Retain nucleus without replacing it with a finer compartment. Supporting Evidence: PMID:22912871 IAA7-GFP and IAA17-GFP localized exclusively to the nucleus |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: Retain nuclear localization with the actual assay or inference scope. Reason: PMID:22912871 directly images IAA17-GFP as a nuclear positive control in Arabidopsis mesophyll protoplasts; PMID:11283339 independently tests nuclear accumulation. The IAA8-focused title does not exclude these IAA17 experiments. Retain nucleus without replacing it with a finer compartment. Supporting Evidence: PMID:22912871 IAA7-GFP and IAA17-GFP localized exclusively to the nucleus |
| GO:0005634 nucleus | ISM GO_REF:0000122 | ACCEPT | Summary: Retain nuclear localization with the actual assay or inference scope. Reason: PMID:22912871 directly images IAA17-GFP as a nuclear positive control in Arabidopsis mesophyll protoplasts; PMID:11283339 independently tests nuclear accumulation. The IAA8-focused title does not exclude these IAA17 experiments. Retain nucleus without replacing it with a finer compartment. Supporting Evidence: PMID:22912871 IAA7-GFP and IAA17-GFP localized exclusively to the nucleus |
| GO:0006355 regulation of DNA-templated transcription | IBA GO_REF:0000033 | MODIFY | Summary: Refine transcriptional regulation to the demonstrated repressive direction. Reason: IAA17 functions as an Aux/IAA repressor of ARF-dependent transcription; negative regulation is the supported specific process. For IAA12 and IAA17 it is already represented elsewhere in this review; refinement does not manufacture new coverage. IAA19 assignment combines its direct ARF7 interaction, dominant repressor phenotypes and feedback experiments, rather than treating auxin-induced expression alone as participation. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: PANTHER:PTN001272225 SUPPORTS TRANSFER The inherited broad claim is retained as true; target-specific repression/signaling evidence supports a narrower term. No ancestral-node error, loss or donor circularity is asserted. Proposed replacements: negative regulation of DNA-templated transcription Supporting Evidence: PMID:14742873 GD-IAA17[I/mII] PMID:14742873 causing nearly complete repression in an auxin-independent manner |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000002 | MODIFY | Summary: Refine transcriptional regulation to the demonstrated repressive direction. Reason: IAA17 functions as an Aux/IAA repressor of ARF-dependent transcription; negative regulation is the supported specific process. For IAA12 and IAA17 it is already represented elsewhere in this review; refinement does not manufacture new coverage. IAA19 assignment combines its direct ARF7 interaction, dominant repressor phenotypes and feedback experiments, rather than treating auxin-induced expression alone as participation. Proposed replacements: negative regulation of DNA-templated transcription Supporting Evidence: PMID:14742873 GD-IAA17[I/mII] PMID:14742873 causing nearly complete repression in an auxin-independent manner |
| GO:0009733 response to auxin | IEP PMID:17919906 Salicylic acid inhibits pathogen growth in plants through re... | MODIFY | Summary: Refine the broad auxin response to auxin-activated signaling. Reason: IAA17 itself performs the repressive ARF-regulatory step of auxin signaling; it is not merely an auxin-induced transcript. The primary mechanism and mutant/interaction experiments support GO:0009734, already present for IAA17. The row-specific PMID:17919906 is retained as provenance; expression evidence alone is not the reason for this refinement. Proposed replacements: auxin-activated signaling pathway Supporting Evidence: PMID:11283339 increase the half-life of the iaa17/axr3-1 protein by sevenfold |
| GO:0009733 response to auxin | IMP PMID:9478901 Changes in auxin response from mutations in an AUX/IAA gene. | MODIFY | Summary: Refine the broad auxin response to auxin-activated signaling. Reason: IAA17 itself performs the repressive ARF-regulatory step of auxin signaling; it is not merely an auxin-induced transcript. The primary mechanism and mutant/interaction experiments support GO:0009734, already present for IAA17. The row-specific PMID:9478901 is retained as provenance; expression evidence alone is not the reason for this refinement. Proposed replacements: auxin-activated signaling pathway Supporting Evidence: PMID:11283339 increase the half-life of the iaa17/axr3-1 protein by sevenfold |
| GO:0009733 response to auxin | TAS PMID:12036262 Genetics of Aux/IAA and ARF action in plant growth and devel... | MODIFY | Summary: Refine the broad auxin response to auxin-activated signaling. Reason: IAA17 itself performs the repressive ARF-regulatory step of auxin signaling; it is not merely an auxin-induced transcript. The primary mechanism and mutant/interaction experiments support GO:0009734, already present for IAA17. The row-specific PMID:12036262 is retained as provenance; expression evidence alone is not the reason for this refinement. Proposed replacements: auxin-activated signaling pathway Supporting Evidence: PMID:11283339 increase the half-life of the iaa17/axr3-1 protein by sevenfold |
| GO:0009734 auxin-activated signaling pathway | TAS PMID:11283339 IAA17/AXR3: biochemical insight into an auxin mutant phenoty... | ACCEPT | Summary: IAA17 is an auxin-regulated transcriptional signaling repressor. Reason: The original PMID:11283339 combines protein stability, nuclear accumulation and ARF interaction studies. The axr3-1 domain-II allele extends protein half-life; it is a stabilized gain-of-function repressor. This is a mechanistic signaling role, not annotation to the proteolysis of IAA17 merely as a substrate. Supporting Evidence: PMID:11283339 increase the half-life of the iaa17/axr3-1 protein by sevenfold |
| GO:0042802 identical protein binding | IPI PMID:21734647 The auxin signalling network translates dynamic input into r... | KEEP AS NON CORE | Summary: Retain experimentally annotated self-association without requiring a universal homodimer. Reason: PMID:21734647 supplies the original IAA17 self-interaction assertion. Aux/IAA PB1-mediated oligomerization is compatible with this observation, but identical-protein binding is not the main transcriptional activity and does not establish an obligatory native stoichiometry. For network sources, retain the curated pair-level assertion with heterologous assay limits; no unmeasured in-planta self-complex is inferred. Supporting Evidence: PMID:21734647 In this network, the vast majority of the Aux/IAAs interact with all the ARF activators PMID:11283339 the iaa17/axr3-1 mutation does not affect homodimerization |
| GO:0042802 identical protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | KEEP AS NON CORE | Summary: Retain experimentally annotated self-association without requiring a universal homodimer. Reason: PMID:32612234 supplies the original IAA17 self-interaction assertion. Aux/IAA PB1-mediated oligomerization is compatible with this observation, but identical-protein binding is not the main transcriptional activity and does not establish an obligatory native stoichiometry. For network sources, retain the curated pair-level assertion with heterologous assay limits; no unmeasured in-planta self-complex is inferred. Supporting Evidence: PMID:32612234 a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein-protein interactions PMID:11283339 the iaa17/axr3-1 mutation does not affect homodimerization |
| GO:1900057 positive regulation of leaf senescence | IMP PMID:25324183 INDOLE-3-ACETIC ACID INDUCIBLE 17 positively modulates natur... | KEEP AS NON CORE | Summary: IAA17 positively modulates natural leaf senescence in the tested Arabidopsis context. Reason: PMID:25324183 explicitly reports earlier senescence in overexpression plants and delayed senescence in knockout plants, with melatonin effects and SEN4/SAG12 expression changes. Retain this contextual process without generalizing to every tissue or claiming that IAA17 directly binds melatonin. The abstract supports the direction; no missing full-text negative is invented. Supporting Evidence: PMID:25324183 AtIAA17 knockout mutants displayed delayed leaf senescence with higher chlorophyll content |
| GO:0045892 negative regulation of DNA-templated transcription | IDA PMID:14742873 Aux/IAA proteins contain a potent transcriptional repression... | NEW | Summary: Inherited, experimentally supported negative-transcription proposal retained. Reason: This row predates the current audit. PMID:14742873 directly tests IAA17 domain-I repression constructs. The existing broad GO:0006355 rows are refined to this already represented specific term; this inherited proposal is not counted as newly added coverage and no extra process assertion is created. Supporting Evidence: PMID:14742873 GD-IAA17[I/mII] PMID:14742873 causing nearly complete repression in an auxin-independent manner |
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Download this section (compressed HTML)Q: Should Aux/IAA proteins carry contributes_to auxin binding / auxin receptor activity, given that the Aux/IAA degron completes the auxin-binding pocket of TIR1/AFB?
Q: Is the reported role of IAA17 in leaf senescence a direct consequence of ARF repression in leaves, and which ARFs mediate it?
Q: Does Aux/IAA regulatory-DNA association observed in yeast one-hybrid assays involve direct sequence-specific DNA contacts or an unidentified bridging component in that assay, and what is its native significance?
Experiment: Map in planta IAA17-ARF partner preference (e.g. ARF7/ARF19 in lateral root founder cells versus ARF5) using tissue-specific proximity labelling or FRET-FLIM.
Hypothesis: IAA17 preferentially represses specific activator ARFs in the root, explaining axr3-1 root phenotypes.
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