JAZ1, also known as TIFY10A, is a nuclear JASMONATE ZIM-domain repressor in Arabidopsis jasmonate signaling. In low-jasmonate states, JAZ proteins repress MYC transcription factors and recruit co-repressor machinery through the TIFY/ZIM domain. JA-Ile promotes COI1-JAZ1 interaction and JAZ1 degradation, releasing jasmonate-responsive transcription. Its roles in defense, flower and pollen development, wounding, and alkaline-stress responses are downstream or specialized outputs of this core jasmonate-repressor module.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005634 nucleus | IDA PMID:17637677 JAZ repressor proteins are targets of the SCF(COI1) complex ... | ACCEPT | Summary: JAZ1 is nuclear, consistent with its transcriptional repressor role. Reason: Nuclear localization is the correct cellular context for JAZ1 repression of transcription factors. |
| GO:0042802 identical protein binding | IPI PMID:19309455 The ZIM domain mediates homo- and heteromeric interactions b... | ACCEPT | Summary: The JAZ ZIM/TIFY domain mediates homo- and heteromeric JAZ interactions. Reason: Unlike generic protein binding, JAZ dimerization/oligomerization reflects the ZIM/TIFY interaction module that helps assemble JAZ-NINJA-TOPLESS repression complexes. |
| GO:0042802 identical protein binding | IPI PMID:21798944 Evidence for network evolution in an Arabidopsis interactome... | ACCEPT | Summary: High-throughput interactome evidence supports JAZ1 self or family protein interaction. Reason: This is consistent with documented ZIM/TIFY-domain JAZ interaction that contributes to corepressor assembly, not merely generic protein binding. Supporting Evidence: file:ARATH/JAZ1/JAZ1-uniprot.txt Q9LMA8; Q9LMA8: TIFY10A; NbExp=7 |
| GO:0042802 identical protein binding | IPI PMID:32612234 Extensive signal integration by the phytohormone protein net... | ACCEPT | Summary: Phytohormone network evidence supports JAZ1 protein interaction. Reason: This is consistent with documented ZIM/TIFY-domain JAZ interaction that contributes to corepressor assembly, not merely generic protein binding. Supporting Evidence: file:ARATH/JAZ1/JAZ1-uniprot.txt Q9LMA8; Q9LMA8: TIFY10A; NbExp=7 |
| GO:0042742 defense response to bacterium | IMP PMID:18547396 A critical role of two positively charged amino acids in the... | KEEP AS NON CORE | Summary: JAZ1 affects bacterial/coronatine defense responses through jasmonate signaling. Reason: Defense response is a downstream output of JAZ1 regulation of JA signaling. |
| GO:0009908 flower development | IMP PMID:17637677 JAZ repressor proteins are targets of the SCF(COI1) complex ... | KEEP AS NON CORE | Summary: JAZ1 affects flower development through JA signaling outputs. Reason: Flower development is a downstream physiological output rather than JAZ1's core repressor function. |
| GO:0009867 jasmonic acid mediated signaling pathway | IMP PMID:17637677 JAZ repressor proteins are targets of the SCF(COI1) complex ... | MODIFY | Summary: JAZ1 is part of jasmonate signaling, but its specific role is regulation/repression of that pathway. Reason: The more precise process term for JAZ1 is regulation of jasmonic acid mediated signaling. Proposed replacements: regulation of jasmonic acid mediated signaling pathway |
| GO:0009555 pollen development | IMP PMID:17637677 JAZ repressor proteins are targets of the SCF(COI1) complex ... | KEEP AS NON CORE | Summary: JAZ1 affects pollen-related JA developmental outputs. Reason: Pollen development is a downstream phenotype of JA signaling. |
| GO:1900067 regulation of cellular response to alkaline pH | IMP PMID:25375909 The positive regulatory roles of the TIFY10 proteins in plan... | KEEP AS NON CORE | Summary: TIFY10 proteins have reported roles in alkaline-stress response. Reason: This is a specialized organismal stress-output annotation, not a direct molecular mechanism or the central JAZ1 JA-repressor role. |
| GO:0009753 response to jasmonic acid | IEP PMID:17637677 JAZ repressor proteins are targets of the SCF(COI1) complex ... | KEEP AS NON CORE | Summary: JAZ1 expression and stability respond to jasmonate. Reason: The response term is correct but less mechanistic than regulation of JA signaling by a nuclear repressor. |
| GO:0031347 regulation of defense response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: JAZ1 family context supports regulation of defense outputs. Reason: Defense regulation is downstream of JAZ1 control of jasmonate transcriptional signaling. |
| GO:2000022 regulation of jasmonic acid mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: JAZ1 regulates jasmonate signaling as a repressor degraded by SCF(COI1). Reason: This captures the core biological process controlled by JAZ1. |
| GO:0009611 response to wounding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: JAZ1 participates in wound-responsive JA signaling. Reason: Wound response is a downstream JA output rather than the core repressor mechanism. |
| GO:0003714 transcription corepressor activity | IPI PMID:20360743 NINJA connects the co-repressor TOPLESS to jasmonate signall... | NEW | Summary: JAZ proteins repress MYC transcription factors through corepressor machinery. Reason: The seeded GO annotations do not capture JAZ1's direct transcriptional corepressor role. Supporting Evidence: file:ARATH/JAZ1/JAZ1-uniprot.txt Repressor of jasmonate responses. file:ARATH/JAZ1/JAZ1-deep-research-falcon.md PMID:17637677 JAZ1 protein acts to repress transcription of jasmonate-responsive genes PMID:20360743 In an unelicited state, JAZ proteins bind the transcription factor MYC2 and inactivate its function PMID:20360743 Secondly, interaction of JAZ1 with MYC3, a close relative to MYC2, was observed. PMID:20360743 We focused on an uncharacterized protein isolated in the TAP analysis (Fig. 1a), hereafter designated NINJA |
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Download this section (compressed HTML)Q: Should JAZ-family annotations use transcription corepressor activity directly, or should this be represented through a more specific JAZ-NINJA-TOPLESS complex model?
Q: Which JAZ1 defense and alkaline-stress annotations remain direct enough for gene-level GO annotation?
Experiment: Test native JAZ1 occupancy and MYC transcriptional repression before and after JA-Ile treatment using time-resolved chromatin and proteomics assays.
Experiment: Separate TIFY-domain dimerization effects from NINJA/TOPLESS recruitment using JAZ1 domain mutants in native expression contexts.
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