id: E1BL04
gene_symbol: E1BL04
taxon:
  id: NCBITaxon:9913
  label: Bos taurus
status: COMPLETE
description: >-
  The three broad predictions agree with the actin-associated function of XIRP2 and are less specific
  than existing annotations.
source_documents:
  - genes/BOVIN/E1BL04/E1BL04-uniprot.txt
  - genes/BOVIN/E1BL04/E1BL04-goa.tsv
  - publications/PMID_15454575.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0030036
      label: actin cytoskeleton organization
    predicted_term_type: GO_BP
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target has Xin actin-binding repeats and an XIRP2 subfamily assignment. Experiments on Xin
        repeats, including human XIRP2 repeats, demonstrate actin binding and stabilization of the actin
        cytoskeleton (PMID:15454575), supporting transfer of the broad process to bovine XIRP2. The cached
        IBA annotation actin filament organization is more specific than actin cytoskeleton organization.
        The prediction is therefore supported but less precise.
      supported_by:
        - reference_id: file:BOVIN/E1BL04/E1BL04-uniprot.txt
          supporting_text: >-
            ID   E1BL04_BOVIN            Unreviewed;      3561 AA. ... DR   GO; GO:0051015; F:actin filament
            binding; IBA:GO_Central. ... DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
            ... DR   InterPro; IPR012510; Actin-binding_Xin_repeat. ... DR   PANTHER; PTHR22591:SF1; XIN
            ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1.
        - reference_id: PMID:15454575
          supporting_text: >-
            Human XIRP2 contains 28 Xin repeats with properties identical to those of Xin
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0030054
      label: cell junction
    predicted_term_type: GO_CC
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target is a Xin-repeat protein in the XIRP2 subfamily. Xin-family localization at muscle attachment
        sites and the repeat-mediated actin interactions provide a biological basis for junction association
        (PMID:15454575), consistent with the target focal-adhesion IBA. The cached annotations include
        focal adhesion and cell-cell junction, which specify junction types beyond the predicted cell
        junction. The broad prediction is supported but less precise.
      supported_by:
        - reference_id: file:BOVIN/E1BL04/E1BL04-uniprot.txt
          supporting_text: >-
            ID   E1BL04_BOVIN            Unreviewed;      3561 AA. ... DR   GO; GO:0051015; F:actin filament
            binding; IBA:GO_Central. ... DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
            ... DR   InterPro; IPR012510; Actin-binding_Xin_repeat. ... DR   PANTHER; PTHR22591:SF1; XIN
            ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1.
        - reference_id: PMID:15454575
          supporting_text: >-
            Human XIRP2 contains 28 Xin repeats with properties identical to those of Xin
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0003779
      label: actin binding
    predicted_term_type: GO_MF
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        Xin repeats are experimentally established actin-binding modules, and human XIRP2 repeats share
        this activity (PMID:15454575). The bovine target contains these repeats and has a curated IBA
        for actin filament binding. Actin binding is a broader molecular function than that existing annotation.
        It is biologically correct but adds no specificity.
      supported_by:
        - reference_id: file:BOVIN/E1BL04/E1BL04-uniprot.txt
          supporting_text: >-
            ID   E1BL04_BOVIN            Unreviewed;      3561 AA. ... DR   GO; GO:0051015; F:actin filament
            binding; IBA:GO_Central. ... DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
            ... DR   InterPro; IPR012510; Actin-binding_Xin_repeat. ... DR   PANTHER; PTHR22591:SF1; XIN
            ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1.
        - reference_id: PMID:15454575
          supporting_text: >-
            Human XIRP2 contains 28 Xin repeats with properties identical to those of Xin
references:
  - id: file:BOVIN/E1BL04/E1BL04-uniprot.txt
    title: E1BL04-uniprot.txt
  - id: PMID:15454575
    title: Xin repeats define a novel actin-binding motif.