ID E1BL04_BOVIN Unreviewed; 3561 AA. AC E1BL04; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 29-MAY-2024, sequence version 4. DT 10-JUN-2026, entry version 87. DE SubName: Full=Xin actin binding repeat containing 2 {ECO:0000313|Ensembl:ENSBTAP00000023600.7}; GN Name=XIRP2 {ECO:0000313|Ensembl:ENSBTAP00000023600.7, GN ECO:0000313|VGNC:VGNC:36986}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023600.7, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000023600.7} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023600.7}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000023600.7} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023600.7}; RG Ensembl; RL Submitted (JAN-2026) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}. CC -!- DOMAIN: Xin repeats bind F-actin. {ECO:0000256|PROSITE- CC ProRule:PRU00721}. CC -!- SIMILARITY: Belongs to the Xin family. {ECO:0000256|PROSITE- CC ProRule:PRU00721}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR FunCoup; E1BL04; 104. DR STRING; 9913.ENSBTAP00000023600; -. DR PaxDb; 9913-ENSBTAP00000023600; -. DR Ensembl; ENSBTAT00000023600.7; ENSBTAP00000023600.7; ENSBTAG00000017743.8. DR VEuPathDB; HostDB:ENSBTAG00000017743; -. DR VGNC; VGNC:36986; XIRP2. DR eggNOG; KOG1700; Eukaryota. DR GeneTree; ENSGT00530000063779; -. DR HOGENOM; CLU_000319_0_0_1; -. DR InParanoid; E1BL04; -. DR OrthoDB; 6129702at2759; -. DR Proteomes; UP000009136; Chromosome 2. DR Bgee; ENSBTAG00000017743; Expressed in rectus femoris and 30 other cell types or tissues. DR ExpressionAtlas; E1BL04; baseline. DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl. DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl. DR GO; GO:0001725; C:stress fiber; IEA:Ensembl. DR GO; GO:0030018; C:Z disc; IEA:Ensembl. DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central. DR GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl. DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central. DR GO; GO:1903829; P:positive regulation of protein localization; IEA:Ensembl. DR GO; GO:0110053; P:regulation of actin filament organization; IEA:Ensembl. DR InterPro; IPR012510; Actin-binding_Xin_repeat. DR InterPro; IPR030072; XIRP1/XIRP2. DR PANTHER; PTHR22591; XIN; 1. DR PANTHER; PTHR22591:SF1; XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1. DR Pfam; PF08043; Xin; 18. DR PROSITE; PS51389; XIN; 26. PE 3: Inferred from homology; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE- KW ProRule:PRU00721}; Cell junction {ECO:0000256|ARBA:ARBA00022949}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT REPEAT 569..584 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 604..619 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 644..659 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 681..696 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 719..734 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 759..774 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 797..812 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 835..850 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 869..884 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 903..918 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 940..955 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1045..1060 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1083..1098 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1122..1137 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1155..1170 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1193..1208 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1228..1243 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1267..1282 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1303..1318 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1340..1355 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1378..1393 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1415..1430 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1449..1464 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1480..1495 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1518..1533 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REPEAT 1553..1568 FT /note="Xin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721" FT REGION 148..218 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 422..518 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2143..2192 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2295..2324 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2360..2397 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2417..2554 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2570..2591 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2821..2846 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3097..3196 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3531..3561 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1945..1972 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 165..174 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 191..217 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 422..433 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 436..450 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 451..462 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 463..476 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2143..2152 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2163..2180 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2308..2319 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2383..2394 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2417..2426 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2449..2464 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2471..2483 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2486..2502 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2511..2523 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2570..2580 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2582..2591 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2821..2830 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3114..3124 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3132..3152 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3153..3166 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 3551..3561 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 3561 AA; 404067 MW; 5D7D16EBF9556249 CRC64; MLELKLVLRT ICLVCVPHTV LHKDNLESSM FPMQKGSLNL LRQKWESSDY QKSEYSPRGS RCRLFQPQEN KLLEPEGEVA STPGPPDPPS LLRSVREEIL SVEPEEKCPE DKSDYSRDYG QLEVLKEDSL SGRHRIERFS IALDELRSVF EAPRSGNRQA GPAEYSRKEV EIERNLCSPT FKSHPGSQSD DSVKDSGKKD KETPYDKISS ESGHSHIVEV TTGPIKPASG FAEDTAVQSK SASDLQEVVS LKERMAKYQA AVSRGDCRSF SANMLEESEM CTVPGGLARV KKQFEKDKIA SSSNTFTQYQ YQHQNRSEQE VIRSSQVDIS RCSQEMERNE PEISEAHKID VLGTEMVSHL EKHTEEINQA SKLHQYVQET VIDTPEDEEI PKVSTKFLKE QFEKSVQEKV LYSDKELTPA KQIKMESESE ETLKPSSIVG TSSTSYTSTS QRKETSTTRY SDHSATSSTL AQINATPSEK TEEFPPPPPD MLQPPVDVTA FSQSPELPNP PRKPPVPKEL YSKQRNLYEL NRLYKHIHPE LRKNLEKDYI SEVSEIVSRQ MNAGSSVSAD VQQARYVFEN TNDSSQKGLN SEREHVEWDE ILKGEVQSMR WIFENQPLDS INNGSPDEDN ISKGIADQEI IAGGDVKYTT WMFETQPIDT LGDHSSGTEK HAEKIPELAR GDVHTARWMF ETKPLDSMNK LHQSQEESIA TAIKDITGGD VKTVRYMFET QHLDQLGQLH SVDEMHLLQL RSELKEIKGN VKRSIKYFET QPLYVIRDGS GQMLEIKTVH REDVEKGDVR TARWMFETQP LDTINKDITE IKVVRGISME ENVKGGVHRA KWLFETQPLE KIKEETEEVI VEKETVIGTD VSKKCWMFET QPLDILKEVP DADHLKSEEI IGGDVQTTKQ LFETLPIEAL KDSPDVGKLQ KITASEEEKG DVRHQKWIFE TQPLEEIRED KKEYIRTVKL EEVDRGDVRN YTHIFESNNL IKFDASHKIE VEGVTRGAVE LNKSLFETTP LYAIQDHLGK YHQVKTVQQE EILRGDVRSC RWLFETRPID QFDESIHKYQ IIRGISAQEI QTGNVKSAKW LFETQPLDSI KHFSNMEEVE RKTEQVTDIV KGDVKTCRWL FETQPMESLY EKVSLMTGSK EIHKGDVKAC TWLFETQPLD TIKDDSEATV KLQTVKQEEI HGGDVRTTCF LFETENLDSI QGEEGKEIKA IEMDIQAGDV SSMRHKFESQ SLDSISSGSE EVLRKIKTLK AEDIQKGNVL NCRWLFENQP IDMIKESQEG DELVKTVTDI QGGNVRKGCF IFETFSLDEI KEESDYISTK KTITEEVIKG DVKSYRMLFE TQPLYAIQDR EGFYHEVTTV KKEEVIHGDV RGTRWLFETK PLDSINESET VYVIKSVTQE DIQKGDVSSV RYRFETQPLD QIAKESRDIV PTVDCIQGGD VRKSKQFFES ENLDKNTYVR TVSVNEIQKG NVKTSTWLFE THTLDELRGE GSEYENIKTV TQEDMQKGDV KQAVWLFENQ TLDSIKEADE SITKITKEEI PPADVKTTTW LFETTPLHRF TENRVEKVEI IGKSIKETLG ELYSQKVIEA PGIIIEADEV GDVRMAKYKL MNQASPEIQK EEIIKVDLRN IMVNLLSKRD CKKREILVSE EEKGNVNLTK TQLLNRSTEF HAEKEEIVSG DVQQAIKNLF SEERSVKKGI LIQEDERGDI NMTIYCLLHE NAGDTIKREE IVGGDVKRTI HNLLSSISNN KISERAKIDA SERGNVQFFT TCIETGALDY LRQLQTGSNE ILTGRKQEKE EEIIGGDVEG TKLLLKKRQS QVERTVNETD IIPGDVRNTV KVFLTEPQNT SCKLPKEEII KGDVKSTLNS LSQAVSQKTV AKTEEIIKGD MLTTLKSLKE SSQKWKDSKQ PDVVPGDIEK AIECLEKTAR TRTEILKKEL ILDDLEASLR NLKETQTAFK EVNKSAVKDE VQTVMAGSKE EQKTGTHQVA VQRDKKSILQ PRPGPFEPAA RWQEGADILN QTINKSCHGD LMKERTEVNL PKAPKGPVKI VIDREQNNDA LEKNLRKLSN SHQVGIWTDN MTEQHLRDEH VSGQLTSTLS VREHRKTKEA ETEREQKKEA VFLQSIDKTI GKQQTETGQL RNDYQKIEAF PVKSPKNTKN TKTSTDTQSS RPGLTQGPVN RMVGETREVS EDFQKQTLLK QEKQYSNKDI MKKNVTLQPG WQTLPVNQDM SNVTEVKVSQ KSHNQLKAID KKQTDIHLKS QDFLMKTNTS KDLKMAMEMS FNPIKFNPEN NAKENEFPLP PPSPPPPLPS NASSEIEFPL PPPPPLMMLP EKNVFPPSLS TEKIQAEFEN FPGLPLPPPP EDEKFERECL STFPPPPPPP PAPALKPAHL LSSSVQEKHN GTFIQYSQEE ASSSQAKITT GKSGGRLPPP TLPKPKFPKQ IEDIKNHSSP KVDLENSLPD TECKMTPSKD QKRVITATSS EHIETMQNVS SKSLDKRKQL SMDSTRSFSQ AVPESSPPKK KPIAPLIKSH SFPAGSGQQS PKPYMRKFKT PLMIAEEKYR QQREELEKQR QGSSGYNIVR TESQNQNISE LKKEVLLQKT KEEVPLTGMD SEVTAAQTNP VSQSLSQDLR VCTDNQLSTT PAVTFSAKRL QHVPATLEGK DTMKKEVLQS SKGMIQSKSA CEIKQSQQEY RTQQTQQKHL EQLHLPKSQP VSPSFKVKTM KVPILGHKLD ETNHSYESHK KQSEVDIQTI TKQQYQETGR TEARTEGSSY KHSVTEKHYQ LPAKEKRATI QLPTETTGKS HESKLKIVHE KQREFRESES GKFLGSEETI QGPPMIGPKK ESLIAETKQE HLNISAQKVV EQKVTEAHLD SQTQNFQQTH TQSFESQVEH KKLPQPNNNL QEEKYLGVKG IQQKQVFSNT KESKQEITQN KSLFSSAKES QQDDGKRAVN VLEFLRKREE LQQILSRVKE FEAEPDKNGL KTFQMLLKII PVWLLSEEKR EYGVHIAMEN NIEKIKEEIT HIKTQAEDML VSCENTIQTA MISSKAGKQR NKATSLNETL SKVSNANVSY NKNTQQKENT IVEKAEHHQV ATHQETTAHH QVKTHQEIKL DDAKVPPPSL KTRPSSPTFI TIESTARRTQ TSPKDELSQS PKKDSFAELS PRPSQPTRIL KANTSPSPPK SRSEQLVKLK DTTAKLSRGI IPCSSITPVP IVEKRSEIIT SPATLRRQIK IEARGRDSPP TITIPITVNH ADSGSFKESM EAQEEVRKVE NRSTYVHKDG VNSATDIVPD TECFDAVEII RKVEGPRLSE HAQRYEAANR TVEMAENFMS DHEHEINRWF RGFEDGLSFD TQSNRRAYIN GEANRNIKQE SRSFKEEFGL TSSESTSFTG FSHSRPRELQ EMMPVKLPSI RSETRSLSEH FSGVDAFESQ VVGSKTTVSS SHGSEAGRSR FDFKHAPPTY EDVIAGHILD VSDSPKELRR NFQQTWQESE RVIKNSGYAT SDASATEMET TFQEESAFIR ETATPRQGNM HTLSKDGLSN GVPSSRQAEF S //