mcm-4

Review rationale: No evidence places C. elegans mcm-4, or this 74-residue C-terminal winged-helix fragment of it (canonical MCM-4 residues 750-823), in Pol II transcription initiation. The characterized mcm-4 functions are DNA replication and the replication checkpoint (PMID:21146520), and neither the gene's existing annotations nor its re-reviewed gene record contain a transcription term, so the prediction is novel but unsupported. It is not refuted outright: vertebrate MCM subunits copurify with the Pol II holoenzyme (PMID:10454562), but that association was mapped to an N-terminal segment of MCM2 (residues 168-230; PMID:12392551), it is complex co-purification rather than evidence that MCM-4 performs a step of initiation, and nothing ties it to the MCM4 C-terminal winged-helix region that makes up this product. Whether the fragment is even translated is unknown. The OpenScientist analysis judged the prediction NPI from the replicative-helicase identity of MCM-4; its targeted moonlighting search found no primary evidence for an MCM role in Pol II transcription and did not retrieve the holoenzyme co-purification reports (PMID:10454562, PMID:12392551), which leave the term unsupported rather than refuted.

Review rationale: Nucleus is not novel at the gene level: the canonical mcm-4 product Q95XQ8 carries GO:0005634 by IDA from PMID:21146520, where MCM-4::mCherry was nuclear and associated with chromatin from late anaphase, and GOA keeps the gene's annotations on that representative product. Correctness for this accession is unresolved. A0A061AL94 is only the C-terminal winged-helix region (canonical residues 750-823) from an internal-start gene model, its translation in vivo has not been shown, and the gene review deliberately does not transfer full-length MCM-4 localization or replication functions to it. The prediction therefore agrees with the gene's annotation but lacks support for the deposited sequence itself.