id: A0A061AL94
gene_symbol: mcm-4
taxon:
  id: NCBITaxon:6239
  label: Caenorhabditis elegans
status: COMPLETE
description: >-
  A0A061AL94 is a 74-residue mcm-4 gene product record. Functions and localization of full-length MCM-4
  cannot be assumed to apply intact to this short sequence.
source_documents:
  - genes/CAEEL/A0A061AL94/A0A061AL94-uniprot.txt
  - genes/CAEEL/A0A061AL94/A0A061AL94-goa.tsv
  - publications/PMID_21146520.md
  - genes/CAEEL/A0A061AL94/A0A061AL94-hypotheses/prediction-transcription-initiation/openscientist.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0006367
      label: transcription initiation at RNA polymerase II promoter
    predicted_term_type: GO_BP
    review:
      assessment: NPI
      error_type: FREQUENCY_BIAS
      confidence_score: 0
      summary: >-
        The record links this 74-residue sequence to mcm-4, whose full-length Caenorhabditis elegans
        product is experimentally established in DNA replication and replication checkpoint control
        (PMID:21146520). The focused report showed that A0A061AL94 is the isolated C-terminal MCM4
        winged-helix fragment and that reviewed full-length MCM4 supports replication terms, not Pol
        II transcription-initiation terms. The GO:0006367 prediction is best explained as a frequency-biased
        conflation of winged-helix DNA-binding domains and the word initiation, and is absent from the
        cached annotations.
      supported_by:
        - reference_id: file:CAEEL/A0A061AL94/A0A061AL94-uniprot.txt
          supporting_text: >-
            ID   A0A061AL94_CAEEL        Unreviewed;        74 AA. ... GN   Name=mcm-4 {ECO:0000313|EMBL:CDR32822.1,
            ... DR   Pfam; PF21128; WHD_MCM4; 1.
        - reference_id: PMID:21146520
          supporting_text: >-
            associates with chromatin in late anaphase
        - reference_id: file:CAEEL/A0A061AL94/A0A061AL94-hypotheses/prediction-transcription-initiation/openscientist.md
          supporting_text: >-
            GO:0006367 should **not** be applied to this gene product.
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005634
      label: nucleus
    predicted_term_type: GO_CC
    review:
      assessment: UNC
      confidence_score: 1
      summary: >-
        Full-length C. elegans MCM-4 associates with chromatin and functions in nuclear DNA replication
        (PMID:21146520). The accession being evaluated encodes only 74 residues, so transfer of nuclear
        localization requires evidence that this fragment retains targeting or complex-association determinants
        or represents an incomplete model of the full-length product. The inspected sources do not resolve
        that relationship experimentally. Nucleus is absent from the cached annotations and is uncertain
        for the deposited sequence, despite being appropriate for full-length MCM-4.
      supported_by:
        - reference_id: file:CAEEL/A0A061AL94/A0A061AL94-uniprot.txt
          supporting_text: >-
            ID   A0A061AL94_CAEEL        Unreviewed;        74 AA. ... GN   Name=mcm-4 {ECO:0000313|EMBL:CDR32822.1,
            ... DR   Pfam; PF21128; WHD_MCM4; 1.
        - reference_id: PMID:21146520
          supporting_text: >-
            associates with chromatin in late anaphase
references:
  - id: file:CAEEL/A0A061AL94/A0A061AL94-uniprot.txt
    title: A0A061AL94-uniprot.txt
  - id: PMID:21146520
    title: C. elegans MCM-4 is a general DNA replication and checkpoint component with an
      epidermis-specific requirement for growth and viability.
  - id: file:CAEEL/A0A061AL94/A0A061AL94-hypotheses/prediction-transcription-initiation/openscientist.md
    title: openscientist.md