id: A0A4W3GVU1
gene_symbol: A0A4W3GVU1
taxon:
  id: NCBITaxon:7868
  label: Callorhinchus milii
status: COMPLETE
description: >-
  The ESRP1-family assignment and retention of the characterized nuclear-localization peptide support
  the existing nuclear annotation.
source_documents:
  - genes/CALMI/A0A4W3GVU1/A0A4W3GVU1-uniprot.txt
  - genes/CALMI/A0A4W3GVU1/A0A4W3GVU1-goa.tsv
  - publications/PMID_28634384.md
  - genes/CALMI/A0A4W3GVU1/A0A4W3GVU1-hypotheses/prediction-nucleus-localization/openscientist.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005634
      label: nucleus
    predicted_term_type: GO_CC
    review:
      assessment: CNN
      confidence_score: 2
      summary: >-
        The target is an ESRP1-family RNA-binding protein with an ESRP1 RRM assignment and the sequence
        GLSPPPCKLPCLSPP. Experiments on mammalian ESRP1 identify this peptide region as sufficient for
        nuclear localization and show that splice isoforms lacking CKLP can instead be cytoplasmic (PMID:28634384).
        Retention of the nuclear peptide supports transfer to this Callorhinchus sequence, without claiming
        that every ESRP1 isoform is nuclear. The exact nucleus annotation is already present in both cached
        UniProt and GOA.
      supported_by:
        - reference_id: file:CALMI/A0A4W3GVU1/A0A4W3GVU1-uniprot.txt
          supporting_text: >-
            ID   A0A4W3GVU1_CALMI        Unreviewed;       684 AA. ... DR   GO; GO:0005634; C:nucleus;
            IEA:UniProtKB-SubCell. ... DR   InterPro; IPR050666; ESRP. ... DR   InterPro; IPR034427; ESRP1_RRM1.
            ... FT   DOMAIN          324..404 ... FT                   /note="RRM"
        - reference_id: PMID:28634384
          supporting_text: >-
            GLSPPPCKLPCLSPP
        - reference_id: file:CALMI/A0A4W3GVU1/A0A4W3GVU1-hypotheses/prediction-nucleus-localization/openscientist.md
          supporting_text: >-
            The nucleus prediction is correct and well-supported.
references:
  - id: file:CALMI/A0A4W3GVU1/A0A4W3GVU1-uniprot.txt
    title: A0A4W3GVU1-uniprot.txt
  - id: PMID:28634384
    title: Alternative splicing regulates distinct subcellular localization of Epithelial splicing
      regulatory protein 1 (Esrp1) isoforms.
  - id: file:CALMI/A0A4W3GVU1/A0A4W3GVU1-hypotheses/prediction-nucleus-localization/openscientist.md
    title: openscientist.md