ID   A0A4W3GVU1_CALMI        Unreviewed;       684 AA.
AC   A0A4W3GVU1;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   10-JUN-2026, entry version 29.
DE   RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN   Name=esrp1 {ECO:0000313|Ensembl:ENSCMIP00000007130.1};
OS   Callorhinchus milii (Ghost shark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX   NCBI_TaxID=7868 {ECO:0000313|Ensembl:ENSCMIP00000007130.1, ECO:0000313|Proteomes:UP000314986};
RN   [1] {ECO:0000313|Proteomes:UP000314986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17185593; DOI=10.1126/science.1130708;
RA   Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA   Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA   Brenner S.;
RT   "Ancient noncoding elements conserved in the human genome.";
RL   Science 314:1892-1892(2006).
RN   [2] {ECO:0000313|Proteomes:UP000314986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17407382;
RA   Venkatesh B., Kirkness E.F., Loh Y.H., Halpern A.L., Lee A.P., Johnson J.,
RA   Dandona N., Viswanathan L.D., Tay A., Venter J.C., Strausberg R.L.,
RA   Brenner S.;
RT   "Survey sequencing and comparative analysis of the elephant shark
RT   (Callorhinchus milii) genome.";
RL   PLoS Biol. 5:E101-E101(2007).
RN   [3] {ECO:0000313|Proteomes:UP000314986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24402279; DOI=10.1038/nature12826;
RG   International Elephant Shark Genome Sequencing Consortium;
RA   Venkatesh B., Lee A.P., Ravi V., Maurya A.K., Lian M.M., Swann J.B.,
RA   Ohta Y., Flajnik M.F., Sutoh Y., Kasahara M., Hoon S., Gangu V., Roy S.W.,
RA   Irimia M., Korzh V., Kondrychyn I., Lim Z.W., Tay B.H., Tohari S.,
RA   Kong K.W., Ho S., Lorente-Galdos B., Quilez J., Marques-Bonet T.,
RA   Raney B.J., Ingham P.W., Tay A., Hillier L.W., Minx P., Boehm T.,
RA   Wilson R.K., Brenner S., Warren W.C.;
RT   "Elephant shark genome provides unique insights into gnathostome
RT   evolution.";
RL   Nature 505:174-179(2014).
RN   [4] {ECO:0000313|Ensembl:ENSCMIP00000007130.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [5] {ECO:0000313|Ensembl:ENSCMIP00000007130.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ESRP family.
CC       {ECO:0000256|ARBA:ARBA00008866}.
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DR   AlphaFoldDB; A0A4W3GVU1; -.
DR   FunCoup; A0A4W3GVU1; 16.
DR   STRING; 7868.ENSCMIP00000007130; -.
DR   Ensembl; ENSCMIT00000007353.1; ENSCMIP00000007130.1; ENSCMIG00000003925.1.
DR   GeneTree; ENSGT00940000157187; -.
DR   InParanoid; A0A4W3GVU1; -.
DR   OMA; FTLTFHV; -.
DR   Proteomes; UP000314986; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12736; RRM1_ESRP1; 1.
DR   CDD; cd12742; RRM3_ESRP1_ESRP2; 1.
DR   FunFam; 3.30.70.330:FF:000041; Epithelial splicing regulatory protein 1; 1.
DR   FunFam; 3.30.70.330:FF:000070; Epithelial splicing regulatory protein 1; 1.
DR   FunFam; 3.30.70.330:FF:000056; epithelial splicing regulatory protein 1 isoform X1; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR050666; ESRP.
DR   InterPro; IPR034427; ESRP1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR013520; Ribonucl_H.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF28441; RRM_11; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314986};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}.
FT   DOMAIN          324..404
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
SQ   SEQUENCE   684 AA;  76499 MW;  D4A0B0B778A55D9D CRC64;
     MTASLDYLVA LFGVTTGAHG RRLGSDEKEL VLLLWQVVDL TNKKVGKVHE VFIKPNNLEL
     TEQCTEETGI TMENLTAAEP LEEVLQQFNR SLSNELNIGV DTSFCLCTFG QLHIRQVLHP
     EACNKNVTLP ECFYSFFDLR KELKKCCPGS PDLHKLDLNS ADLNLEDNAE NNRFGVSDIT
     ATSNVILAII SEPYNHRFTD PERINHKFET GTCSKMEIID DNTIVRARGL PWQSSDQDVA
     RFFRGLNIAK GGAALCLNSQ GRRNGEALVR FVNEEHRDLA LQRHKHHMGN RYIEVYKATG
     EDFLKIAGGT SNEVAHFLSK ENQVIVRMRG LPFTATTEEV LTFFGPKCPV TGGKEGILFV
     KYPDGRPTGD AFVSFACEEY AQNALKKHKD MLGKRYIELF RSTAAEVQQV LNRYTSVPLI
     PIAPAPIIPM LPQPFVCKTN MRDCIRMRGL PYAANIEDIL HFLGEFTCDI RPHGVHMVLN
     QQGRPSGDAF IQMKSTDRAF LTSQRCHKRT MKDRYVEVFQ CSAEEMNFVL LGGTLNRNGL
     SPPPCKLPCL SPPTYTTFPT QTAVISAEAA ALYQQPVLLS PRALQPSTAY YPTSAQLYMN
     YSSYYPSPPG SPTSISYFPA SAAASTVPPQ LGTFVRMQGL AYNTGVKEIL NFFQGYQYPA
     EDCQGLVLDQ ARTLFTHPKE WVCI
//