GND1

UniProt ID: A0A1D8PFS4
Organism: Candida albicans SC5314
Review Status: DRAFT
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Gene Description

TODO: Add description for GND1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: phosphogluconate dehydrogenase (decarboxylating) activity is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009051 pentose-phosphate shunt, oxidative branch
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: pentose-phosphate shunt, oxidative branch is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005829 cytosol
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0050661 NADP binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: NADP binding is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: phosphogluconate dehydrogenase (decarboxylating) activity is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006098 pentose-phosphate shunt
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: pentose-phosphate shunt is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0016491 oxidoreductase activity
IEA
GO_REF:0000043 		ACCEPT
Summary: Manual review: oxidoreductase activity is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0019521 D-gluconate metabolic process
IEA
GO_REF:0000043 		KEEP AS NON CORE
Summary: Manual review: D-gluconate metabolic process may be context-dependent or peripheral for GND1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0050661 NADP binding
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: NADP binding is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0009051 pentose-phosphate shunt, oxidative branch
IEA
GO_REF:0000120 		ACCEPT
Summary: Manual review: pentose-phosphate shunt, oxidative branch is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0062040 fungal biofilm matrix
IDA
PMID:27609602
Null mutants of Candida albicans for cell-wall-related genes... 		KEEP AS NON CORE
Summary: Manual review: fungal biofilm matrix may be context-dependent or peripheral for GND1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
Supporting Evidence:
PMID:27609602
Sep 7. Null mutants of Candida albicans for cell-wall-related genes form fragile biofilms that display an almost identical extracellular matrix proteome.
GO:0005777 peroxisome
IDA
PMID:22094058
Alternative splicing directs dual localization of Candida al... 		KEEP AS NON CORE
Summary: Manual review: peroxisome may be context-dependent or peripheral for GND1.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
Supporting Evidence:
PMID:22094058
Epub 2011 Dec 2. Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes.
GO:0005829 cytosol
IDA
PMID:22094058
Alternative splicing directs dual localization of Candida al... 		ACCEPT
Summary: Manual review: cytosol is consistent with known biology of GND1.
Reason: Retained as supported or plausible for this gene and evidence context.
Supporting Evidence:
PMID:22094058
Epub 2011 Dec 2. Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods.
PMID:22094058
Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes.
PMID:27609602
Null mutants of Candida albicans for cell-wall-related genes form fragile biofilms that display an almost identical extracellular matrix proteome.

📄 View Raw YAML

 
id: A0A1D8PFS4
gene_symbol: GND1
product_type: PROTEIN
taxon:
  id: NCBITaxon:237561
  label: Candida albicans SC5314
description: 'TODO: Add description for GND1'
existing_annotations:
- term:
    id: GO:0004616
    label: phosphogluconate dehydrogenase (decarboxylating) activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: phosphogluconate dehydrogenase (decarboxylating) activity is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009051
    label: pentose-phosphate shunt, oxidative branch
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: pentose-phosphate shunt, oxidative branch is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: cytosol is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0050661
    label: NADP binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: NADP binding is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0004616
    label: phosphogluconate dehydrogenase (decarboxylating) activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: phosphogluconate dehydrogenase (decarboxylating) activity is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006098
    label: pentose-phosphate shunt
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: pentose-phosphate shunt is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0016491
    label: oxidoreductase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: oxidoreductase activity is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0019521
    label: D-gluconate metabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: 'Manual review: D-gluconate metabolic process may be context-dependent or peripheral for GND1.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0050661
    label: NADP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: NADP binding is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0009051
    label: pentose-phosphate shunt, oxidative branch
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'Manual review: pentose-phosphate shunt, oxidative branch is consistent with known biology of GND1.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0062040
    label: fungal biofilm matrix
  evidence_type: IDA
  original_reference_id: PMID:27609602
  review:
    summary: 'Manual review: fungal biofilm matrix may be context-dependent or peripheral for GND1.'
    action: KEEP_AS_NON_CORE
    supported_by:
    - reference_id: PMID:27609602
      supporting_text: Sep 7. Null mutants of Candida albicans for cell-wall-related genes form fragile biofilms that display an almost identical extracellular matrix proteome.
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005777
    label: peroxisome
  evidence_type: IDA
  original_reference_id: PMID:22094058
  review:
    summary: 'Manual review: peroxisome may be context-dependent or peripheral for GND1.'
    action: KEEP_AS_NON_CORE
    supported_by:
    - reference_id: PMID:22094058
      supporting_text: Epub 2011 Dec 2. Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes.
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:22094058
  review:
    summary: 'Manual review: cytosol is consistent with known biology of GND1.'
    action: ACCEPT
    supported_by:
    - reference_id: PMID:22094058
      supporting_text: Epub 2011 Dec 2. Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes.
    reason: Retained as supported or plausible for this gene and evidence context.
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods.
  findings: []
- id: PMID:22094058
  title: Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes.
  findings: []
- id: PMID:27609602
  title: Null mutants of Candida albicans for cell-wall-related genes form fragile biofilms that display an almost identical extracellular matrix proteome.
  findings: []
status: DRAFT