ID A0A8I3PI07_CANLF Unreviewed; 796 AA. AC A0A8I3PI07; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 10-JUN-2026, entry version 21. DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091}; GN Name=CNNM4 {ECO:0000313|Ensembl:ENSCAFP00845032040.1}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845032040.1, ECO:0000313|Proteomes:UP000805418}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00845032040.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Labrador retriever {ECO:0000313|Ensembl:ENSCAFP00845032040.1}; RA Eory L., Zhang W., Schoenebeck J.; RT "Long-read based genome assembly of a Labrador retriever dog."; RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCAFP00845032040.1} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845032040.1}; RG Ensembl; RL Submitted (JAN-2026) to UniProtKB. CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU369091}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU369091}. CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484, CC ECO:0000256|RuleBase:RU369091}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005626114.1; XM_005626057.3. DR RefSeq; XP_038407044.1; XM_038551116.1. DR RefSeq; XP_038536331.1; XM_038680403.1. DR AlphaFoldDB; A0A8I3PI07; -. DR FunCoup; A0A8I3PI07; 35. DR Ensembl; ENSCAFT00845040911.1; ENSCAFP00845032040.1; ENSCAFG00845023175.1. DR GeneID; 481346; -. DR KEGG; cfa:481346; -. DR CTD; 26504; -. DR GeneTree; ENSGT00940000156317; -. DR OrthoDB; 5353557at2759; -. DR Proteomes; UP000805418; Chromosome 10. DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl. DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:Ensembl. DR GO; GO:0010960; P:magnesium ion homeostasis; IBA:GO_Central. DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central. DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1. DR FunFam; 3.10.580.10:FF:000001; Putative metal transporter CNNM3 isoform 2; 1. DR Gene3D; 3.10.580.10; CBS-domain; 1. DR InterPro; IPR045095; ACDP. DR InterPro; IPR000644; CBS_dom. DR InterPro; IPR046342; CBS_dom_sf. DR InterPro; IPR018490; cNMP-bd_dom_sf. DR InterPro; IPR002550; CNNM. DR InterPro; IPR057492; Ig_CNNM1/2/4_N. DR InterPro; IPR044751; Ion_transp-like_CBS. DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1. DR PANTHER; PTHR12064:SF26; METAL TRANSPORTER CNNM4; 1. DR Pfam; PF00571; CBS; 1. DR Pfam; PF25562; CNBH_CNNM2_C; 1. DR Pfam; PF01595; CNNM; 1. DR Pfam; PF25511; Ig_CNNM4_N; 1. DR SUPFAM; SSF51206; cAMP-binding domain-like; 1. DR SUPFAM; SSF54631; CBS-domain pair; 1. DR PROSITE; PS51371; CBS; 1. DR PROSITE; PS51846; CNNM; 1. PE 3: Inferred from homology; KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE- KW ProRule:PRU00703}; Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000805418}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU01193}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE- KW ProRule:PRU01193}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT SIGNAL 1..37 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 38..796 FT /note="Metal transporter" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5047977805" FT TRANSMEM 182..206 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT TRANSMEM 240..261 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT TRANSMEM 267..286 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT TRANSMEM 298..318 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT DOMAIN 178..358 FT /note="CNNM transmembrane" FT /evidence="ECO:0000259|PROSITE:PS51846" FT DOMAIN 445..511 FT /note="CBS" FT /evidence="ECO:0000259|PROSITE:PS51371" SQ SEQUENCE 796 AA; 88787 MW; 43CB0FBCF810AD79 CRC64; MAPVGGGGLP GGGPARGRLL LAALLLPVLM WARGARGQGD PQRGAILGMR LASCNKTCGM NPDGIIFVSE GSTVNLRLYG QRLGSISSNL ISFTEVDNSE AVHNSTNCPE LTKDLVVQQL VNLSRGNTSG MLVVLTKFLR RSENMKLYAL CTRAGVDGPW QRWTDKDSLL FMVEEGGRVL PLWLHILLIM VLLVLSGIFS GLNLGLMALD PMELRIVQNC GTQKERRYAR KIEPIRRKGN YLLCSLLLGN VLVNTSLTIL LDNLIGSGLM AVASSTIGIV IFGEIVPQAL CSRHGLAVGA NTIILTKFFM LLTFPLSFPI SKLLDFVLGQ EIRTVYNREK LMEMLKVTEP YNDLVKEELN MIQGALELRT KTVEDIMTQL QDCFMIRSDA ILDFNTMSEI MESGYTRIPV FEDEQSNIVD ILYVKDLAFV DPDDCTPLKT ITRFYNHPVH FVFHDTKLDA MLEEFKKGKS HLAIVQKVNN EGEGDPFYEV LGLVTLEDVI EEIIKSEILD ESDMYTDNRS RKRVSEKNKR DFSAFKDADN ELKVKISPQL LLAAHRFLAT EVPQFSPSLI SEKILLRLLK YPDVIQELKF DEHNKYYIRH YLYTRNKPAD YFILILQGKV EVEAGKENMK FETGAFSYYG TMALSSPTTV PSTQVGCPPG KRNSLLSWLS DHSPSHPTTL SRSASLSYPD RTELSSTATL AGSSNQFGSS ILGQYISDFS VRALMDLQYI KITRQQYQNG LLASRMENCP QFPLDGCTIC TDNLAGKSEL PVVDETTTLL NERNSLLHKA SHESAI //