id: A0A2I0M3K7
gene_symbol: A0A2I0M3K7
taxon:
  id: NCBITaxon:8932
  label: Columba livia
status: COMPLETE
description: >-
  The short TRUB2-family sequence supports a pseudouridine-synthase relationship, but tRNA substrate specificity
  is unresolved.
source_documents:
  - genes/COLLI/A0A2I0M3K7/A0A2I0M3K7-uniprot.txt
  - genes/COLLI/A0A2I0M3K7/A0A2I0M3K7-goa.tsv
  - publications/PMID_27974379.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0106029
      label: tRNA pseudouridine synthase activity
    predicted_term_type: GO_MF
    review:
      assessment: UNC
      confidence_score: 1
      summary: >-
        The target has TRUB2-specific family assignments and a partial pseudouridine-synthase architecture
        in only 142 residues. Human TRUB2/RPUSD3 perturbation implicates these proteins in mitochondrial
        mRNA pseudouridylation (PMID:27974379); this does not establish the tRNA-specific activity predicted
        here. Generic pseudouridine synthase activity in the cached annotations is not equivalent to tRNA
        pseudouridine synthase activity. A complete catalytic sequence and evidence for tRNA as a substrate
        are needed, while the available study does not by itself exclude additional tRNA activity.
      supported_by:
        - reference_id: file:COLLI/A0A2I0M3K7/A0A2I0M3K7-uniprot.txt
          supporting_text: >-
            ID   A0A2I0M3K7_COLLI        Unreviewed;       142 AA. ... DR   InterPro; IPR039048; Trub2.
            ... DR   PANTHER; PTHR13195:SF0; PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL; 1. ... FT   DOMAIN          1..54
            ... FT                   /note="Pseudouridine synthase II N-terminal"
        - reference_id: PMID:27974379
          supporting_text: >-
            TRUB2/RPUSD3 were similarly involved in pseudouridylating specific residues in mitochondrial
            mRNAs
references:
  - id: file:COLLI/A0A2I0M3K7/A0A2I0M3K7-uniprot.txt
    title: A0A2I0M3K7-uniprot.txt
  - id: PMID:27974379
    title: A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell
      viability.