ID   A0A1S3BTE3_CUCME        Unreviewed;       492 AA.
AC   A0A1S3BTE3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   10-JUN-2026, entry version 43.
DE   RecName: Full=mitogen-activated protein kinase {ECO:0000256|ARBA:ARBA00012411};
DE            EC=2.7.11.24 {ECO:0000256|ARBA:ARBA00012411};
GN   Name=LOC103492960 {ECO:0000313|RefSeq:XP_008451774.1};
OS   Cucumis melo (Muskmelon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX   NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP001652600, ECO:0000313|RefSeq:XP_008451774.1};
RN   [1] {ECO:0000313|RefSeq:XP_008451774.1}
RP   IDENTIFICATION.
RC   TISSUE=Stem {ECO:0000313|RefSeq:XP_008451774.1};
RG   RefSeq;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC         H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00048312};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC         ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00047592};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
CC       protein kinase family. MAP kinase subfamily.
CC       {ECO:0000256|ARBA:ARBA00008832}.
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DR   RefSeq; XP_008451774.1; XM_008453552.3.
DR   AlphaFoldDB; A0A1S3BTE3; -.
DR   SMR; A0A1S3BTE3; -.
DR   GeneID; 103492960; -.
DR   KEGG; cmo:103492960; -.
DR   eggNOG; KOG0660; Eukaryota.
DR   InParanoid; A0A1S3BTE3; -.
DR   OrthoDB; 661390at71240; -.
DR   Proteomes; UP001652600; Chromosome 7.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   CDD; cd07859; STKc_TDY_MAPK; 1.
DR   FunFam; 1.10.510.10:FF:000017; Mitogen-activated protein kinase; 1.
DR   FunFam; 3.30.200.20:FF:000046; Mitogen-activated protein kinase; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR003527; MAP_kinase_CS.
DR   InterPro; IPR050117; MAPK.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   PANTHER; PTHR24055; MITOGEN-ACTIVATED PROTEIN KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS01351; MAPK; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP001652600};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          25..316
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          437..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         54
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   492 AA;  56591 MW;  78CB6224B11DE97E CRC64;
     MPQDHPKKEA KEVNFFTEYG DANRYKILEV VGRGSYGVVC SAIDMQTGEK VAIKRIHDIF
     DHASDAIRIL REVKLLRLLR HPDIVDIKRI MLPPSKKEFR DIYVVFELME SDLHQVIKAN
     DDLTREHHQF FLYQMLRALK FMHTANVYHR DLKPKNILAN ANCKLKICDF GLARVAFSDT
     PTTVFWTDYV ATRWYRAPEL CGSFCSKYTP AIDIWSVGCI FAEVLMGKPL FPGKSVAHQL
     DLITDLLGTP SLETIAGVRN EKVRKYLTEM KKKSAVPFSQ RFPKADPTAI RLLERLLAFN
     PKDRPSAVEA LADPYFKGLA KVEREPSCQP ISRSEFEFER QKLTKDDVRE LLYREILEYH
     PQIREDYLNG TETTKLHYPS VTGHFKSQFT FHKENNGKSA PVLPLERKHF SLPRSTVCTN
     LVSPDHESVR RNPKVCNNSM GLPDRTFGNP SKAYHPPKVP TGRVAGPILP YEHRNIKDVY
     SKLTSQIRSL DF
//