{
  "filename": "ploop_geometry_alphafold.png",
  "iteration": 2,
  "description": "Figure: AlphaFold Cys-to-Arg geometry PTEN vs auxilins",
  "timestamp": "2026-07-09 12:55:05",
  "code": "\nimport matplotlib.pyplot as plt\nprot=['PTEN\\n(active)','Human DNAJC6\\n(auxilin)','Zebrafish\\ndnajc6']\ndcys=[4.8,7.3,7.6]; argid=['Arg130 (P-loop)','Arg199 (non-P-loop)','Arg253 (non-P-loop)']\ncolors=['green','crimson','crimson']\nfig,ax=plt.subplots(figsize=(7.5,4.2))\nb=ax.bar(prot,dcys,color=colors,alpha=0.85)\nax.axhline(6.0,ls='--',color='gray')\nax.text(2.02,6.05,'~6 \u00c5: cradle-forming limit',ha='right',fontsize=8,color='gray')\nax.set_ylabel('Catalytic Cys S\u03b3 \u2192 nearest Arg guanidinium (C\u03b6), \u00c5')\nax.set_title('AlphaFold geometry: P-loop arginine is absent from the\\ncatalytic register in both auxilin orthologs (pseudophosphatase)')\nfor rect,d,lab in zip(b,dcys,argid):\n    ax.text(rect.get_x()+rect.get_width()/2, d+0.15, f'{d} \u00c5\\n{lab}', ha='center',fontsize=8)\nax.set_ylim(0,9)\nplt.tight_layout(); plt.savefig('ploop_geometry_alphafold.png',dpi=130,bbox_inches='tight')\nprint(\"saved ploop_geometry_alphafold.png\")\n"
}