id: Q567K5
gene_symbol: dcxr
taxon:
  id: NCBITaxon:7955
  label: Danio rerio
status: COMPLETE
description: The emitted oxidoreductase GO term is broadly correct but less informative than L-xylulose/carbonyl
  reductase activity. The accompanying FabG acyl-carrier-protein reaction crosses a substrate-specificity
  boundary.
source_documents:
- genes/DANRE/dcxr/dcxr-protnlm-source.json
- genes/DANRE/dcxr/dcxr-notes.md
references:
- id: GO_REF:0000015
  title: Use of the ND evidence code for Gene Ontology (GO) terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: PMID:11882650
  title: Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization
    in kidney.
  findings:
  - statement: Purified mammalian DCXR proteins reduce alpha-dicarbonyls and interconvert xylitol and
      L-xylulose; this supports ortholog-based chemistry rather than a zebrafish assay.
    supporting_text: 'homotetramers with NADPH-linked reductase activity for alpha-dicarbonyl

      compounds, catalyzed the oxidoreduction between xylitol and l-xylulose'
  - statement: The characterized L-xylulose reaction belongs to uronate metabolism, providing the basis
      for broad glucose-metabolism association.
    supporting_text: 'which is involved in the uronate cycle

      of glucose metabolism'
  full_text_unavailable: true
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary report checked against the cached abstract/full text; the evidence scope is
      stated in the finding.
- id: file:DANRE/dcxr/dcxr-bioinformatics/RESULTS.md
  title: Conservation of the DCXR catalytic site
- id: file:DANRE/dcxr/dcxr-fabg-prediction-donor.json
  title: UniProt record identifying the bacterial FabG function donor
- id: file:DANRE/dcxr/dcxr-protnlm-source.json
  title: Frozen exact-input ProtNLM output and UniProt sequence for Q567K5
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-10
  source_reference_id: file:DANRE/dcxr/dcxr-protnlm-source.json
  predicted_term:
    id: GO:0016491
    label: oxidoreductase activity
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: DCXR is an oxidoreductase, but the generic term omits the supported NADPH-linked L-xylulose/carbonyl
      specificity already represented in GOA. The correct broad class does not validate the separate FabG
      function paragraph.
    supported_by:
    - reference_id: PMID:11882650
      supporting_text: 'homotetramers with NADPH-linked reductase activity for alpha-dicarbonyl

        compounds, catalyzed the oxidoreduction between xylitol and l-xylulose'
    - reference_id: file:DANRE/dcxr/dcxr-bioinformatics/RESULTS.md
      supporting_text: '| 1–244 | 1–244 | 169 |'