{
  "accession": "Q567K5",
  "retrieved_at": "2026-09-10T14:34:42.354362+00:00",
  "prediction_url": "https://rest.uniprot.org/uniprotkb/protnlm/Q567K5",
  "prediction_status": 200,
  "prediction": {
    "entryType": "UniProtKB unreviewed (TrEMBL)",
    "primaryAccession": "Q567K5",
    "uniProtkbId": "Q567K5_DANRE",
    "entryAudit": {
      "firstPublicDate": "1111-11-10",
      "lastAnnotationUpdateDate": "1111-11-10",
      "lastSequenceUpdateDate": "1111-11-10",
      "entryVersion": 1,
      "sequenceVersion": 1
    },
    "annotationScore": 0.0,
    "proteinExistence": "5: Uncertain",
    "proteinDescription": {
      "recommendedName": {
        "fullName": {
          "value": "Uncharacterized protein"
        }
      }
    },
    "comments": [
      {
        "texts": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0008006",
                "source": "Google",
                "id": "ProtNLM2",
                "properties": [
                  {
                    "key": "model_score",
                    "value": "0.07"
                  },
                  {
                    "key": "phmmer_accession",
                    "value": "Q9X248"
                  },
                  {
                    "key": "phmmer_score",
                    "value": "132.0"
                  }
                ]
              }
            ],
            "value": "Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis"
          }
        ],
        "commentType": "FUNCTION"
      }
    ],
    "references": [
      {
        "referenceNumber": 1,
        "citation": {
          "id": "CI-FC84BSHK1H4IL",
          "citationType": "unpublished observations"
        },
        "referencePositions": [
          "required field"
        ]
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    ],
    "uniProtKBCrossReferences": [
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        "id": "GO:0016491",
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          {
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            "value": "F:oxidoreductase activity"
          },
          {
            "key": "GoEvidenceType",
            "value": ":-"
          }
        ],
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          {
            "evidenceCode": "ECO:0008006",
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            "id": "ProtNLM2",
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              {
                "key": "model_score",
                "value": "0.93"
              },
              {
                "key": "string_match_text",
                "value": "GO:0004090"
              },
              {
                "key": "string_match_location",
                "value": "GO"
              },
              {
                "key": "string_match_type",
                "value": "hydrated"
              }
            ]
          }
        ]
      }
    ],
    "extraAttributes": {
      "countByCommentType": {
        "FUNCTION": 1
      }
    }
  },
  "uniprot_url": "https://rest.uniprot.org/uniprotkb/Q567K5.json",
  "uniprot_status": 200,
  "uniprot": {
    "entryType": "UniProtKB unreviewed (TrEMBL)",
    "primaryAccession": "Q567K5",
    "secondaryAccessions": [
      "A0A8M1N5D6"
    ],
    "uniProtkbId": "Q567K5_DANRE",
    "entryAudit": {
      "firstPublicDate": "2005-05-10",
      "lastAnnotationUpdateDate": "2026-09-02",
      "lastSequenceUpdateDate": "2005-05-10",
      "entryVersion": 147,
      "sequenceVersion": 1
    },
    "annotationScore": 2.0,
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      "scientificName": "Danio rerio",
      "commonName": "Zebrafish",
      "synonyms": [
        "Brachydanio rerio"
      ],
      "taxonId": 7955,
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        {
          "evidenceCode": "ECO:0000313",
          "source": "EMBL",
          "id": "AAH93141.1"
        }
      ],
      "lineage": [
        "Eukaryota",
        "Metazoa",
        "Chordata",
        "Craniata",
        "Vertebrata",
        "Euteleostomi",
        "Actinopterygii",
        "Neopterygii",
        "Teleostei",
        "Ostariophysi",
        "Cypriniformes",
        "Danionidae",
        "Danioninae",
        "Danio"
      ]
    },
    "proteinExistence": "2: Evidence at transcript level",
    "proteinDescription": {
      "submissionNames": [
        {
          "fullName": {
            "evidences": [
              {
                "evidenceCode": "ECO:0000313",
                "source": "EMBL",
                "id": "AAH93141.1"
              }
            ],
            "value": "Dicarbonyl/L-xylulose reductase"
          }
        }
      ]
    },
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      {
        "geneName": {
          "evidences": [
            {
              "evidenceCode": "ECO:0000313",
              "source": "EMBL",
              "id": "AAH93141.1"
            },
            {
              "evidenceCode": "ECO:0000313",
              "source": "ZFIN",
              "id": "ZDB-GENE-030131-7002"
            }
          ],
          "value": "dcxr"
        }
      }
    ],
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      {
        "texts": [
          {
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                "evidenceCode": "ECO:0000256",
                "source": "ARBA",
                "id": "ARBA00011881"
              }
            ],
            "value": "Homotetramer"
          }
        ],
        "commentType": "SUBUNIT"
      },
      {
        "texts": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000256",
                "source": "ARBA",
                "id": "ARBA00006484"
              }
            ],
            "value": "Belongs to the short-chain dehydrogenases/reductases (SDR) family"
          }
        ],
        "commentType": "SIMILARITY"
      }
    ],
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      {
        "type": "Active site",
        "location": {
          "start": {
            "value": 149,
            "modifier": "EXACT"
          },
          "end": {
            "value": 149,
            "modifier": "EXACT"
          }
        },
        "description": "Proton acceptor",
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "PROSITE-ProRule",
            "id": "PRU10001"
          }
        ]
      }
    ],
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      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "ARBA",
            "id": "ARBA00022857"
          }
        ],
        "id": "KW-0521",
        "category": "Ligand",
        "name": "NADP"
      },
      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000256",
            "source": "ARBA",
            "id": "ARBA00023002"
          }
        ],
        "id": "KW-0560",
        "category": "Molecular function",
        "name": "Oxidoreductase"
      }
    ],
    "references": [
      {
        "referenceNumber": 1,
        "citation": {
          "id": "CI-CBS8FM2MC4ED2",
          "citationType": "submission",
          "authoringGroup": [
            "NIH - Zebrafish Gene Collection (ZGC) project"
          ],
          "publicationDate": "APR-2005",
          "submissionDatabase": "EMBL/GenBank/DDBJ databases"
        },
        "referencePositions": [
          "NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"
        ],
        "referenceComments": [
          {
            "evidences": [
              {
                "evidenceCode": "ECO:0000313",
                "source": "EMBL",
                "id": "AAH93141.1"
              }
            ],
            "value": "Ovary",
            "type": "TISSUE"
          }
        ],
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          {
            "evidenceCode": "ECO:0000313",
            "source": "EMBL",
            "id": "AAH93141.1"
          }
        ]
      }
    ],
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      {
        "database": "EMBL",
        "id": "BC093141",
        "properties": [
          {
            "key": "ProteinId",
            "value": "AAH93141.1"
          },
          {
            "key": "Status",
            "value": "-"
          },
          {
            "key": "MoleculeType",
            "value": "mRNA"
          }
        ]
      },
      {
        "database": "RefSeq",
        "id": "NP_001017619.2",
        "properties": [
          {
            "key": "NucleotideSequenceId",
            "value": "NM_001017619.2"
          }
        ]
      },
      {
        "database": "AlphaFoldDB",
        "id": "Q567K5",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "SMR",
        "id": "Q567K5",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "STRING",
        "id": "7955.ENSDARP00000019859",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "PaxDb",
        "id": "7955-ENSDARP00000019859",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "PeptideAtlas",
        "id": "Q567K5",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "GeneID",
        "id": "550282",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "KEGG",
        "id": "dre:550282",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "AGR",
        "id": "ZFIN:ZDB-GENE-030131-7002",
        "properties": [
          {
            "key": "Description",
            "value": "-"
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        ]
      },
      {
        "database": "CTD",
        "id": "51181",
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          {
            "key": "Description",
            "value": "-"
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        ]
      },
      {
        "database": "ZFIN",
        "id": "ZDB-GENE-030131-7002",
        "properties": [
          {
            "key": "GeneName",
            "value": "dcxr"
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        ]
      },
      {
        "database": "eggNOG",
        "id": "KOG1207",
        "properties": [
          {
            "key": "ToxonomicScope",
            "value": "Eukaryota"
          }
        ]
      },
      {
        "database": "GeneTree",
        "id": "ENSGT00940000154873",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "OMA",
        "id": "FPQWGAY",
        "properties": [
          {
            "key": "Fingerprint",
            "value": "-"
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        ]
      },
      {
        "database": "OrthoDB",
        "id": "1393670at2759",
        "properties": [
          {
            "key": "Description",
            "value": "-"
          }
        ]
      },
      {
        "database": "Reactome",
        "id": "R-DRE-5661270",
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          {
            "key": "PathwayName",
            "value": "Formation of xylulose-5-phosphate"
          }
        ]
      },
      {
        "database": "Bgee",
        "id": "ENSDARG00000079271",
        "properties": [
          {
            "key": "ExpressionPatterns",
            "value": "Expressed in mature ovarian follicle and 26 other cell types or tissues"
          }
        ]
      },
      {
        "database": "GO",
        "id": "GO:0004090",
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          {
            "key": "GoTerm",
            "value": "F:carbonyl reductase (NADPH) activity"
          },
          {
            "key": "GoEvidenceType",
            "value": "IBA:GO_Central"
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        ]
      },
      {
        "database": "GO",
        "id": "GO:0050038",
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            "key": "GoTerm",
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            "key": "GoEvidenceType",
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        ]
      },
      {
        "database": "GO",
        "id": "GO:0006006",
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            "key": "GoTerm",
            "value": "P:glucose metabolic process"
          },
          {
            "key": "GoEvidenceType",
            "value": "IBA:GO_Central"
          }
        ]
      },
      {
        "database": "GO",
        "id": "GO:0005997",
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          {
            "key": "GoTerm",
            "value": "P:xylulose metabolic process"
          },
          {
            "key": "GoEvidenceType",
            "value": "IBA:GO_Central"
          }
        ]
      },
      {
        "database": "CDD",
        "id": "cd05351",
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          {
            "key": "EntryName",
            "value": "XR_like_SDR_c"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "FunFam",
        "id": "3.40.50.720:FF:000214",
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          {
            "key": "EntryName",
            "value": "L-xylulose reductase"
          },
          {
            "key": "MatchStatus",
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        ]
      },
      {
        "database": "Gene3D",
        "id": "3.40.50.720",
        "properties": [
          {
            "key": "EntryName",
            "value": "NAD(P)-binding Rossmann-like Domain"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "InterPro",
        "id": "IPR051737",
        "properties": [
          {
            "key": "EntryName",
            "value": "L-xylulose/Carbonyl_redctase"
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        ]
      },
      {
        "database": "InterPro",
        "id": "IPR036291",
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          {
            "key": "EntryName",
            "value": "NAD(P)-bd_dom_sf"
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        ]
      },
      {
        "database": "InterPro",
        "id": "IPR020904",
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          {
            "key": "EntryName",
            "value": "Sc_DH/Rdtase_CS"
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        ]
      },
      {
        "database": "InterPro",
        "id": "IPR002347",
        "properties": [
          {
            "key": "EntryName",
            "value": "SDR_fam"
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        ]
      },
      {
        "database": "PANTHER",
        "id": "PTHR44252",
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          {
            "key": "EntryName",
            "value": "D-ERYTHRULOSE REDUCTASE"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "PANTHER",
        "id": "PTHR44252:SF3",
        "properties": [
          {
            "key": "EntryName",
            "value": "D-ERYTHRULOSE REDUCTASE-RELATED"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "Pfam",
        "id": "PF13561",
        "properties": [
          {
            "key": "EntryName",
            "value": "adh_short_C2"
          },
          {
            "key": "MatchStatus",
            "value": "1"
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        ]
      },
      {
        "database": "PRINTS",
        "id": "PR00081",
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          {
            "key": "EntryName",
            "value": "GDHRDH"
          }
        ]
      },
      {
        "database": "PRINTS",
        "id": "PR00080",
        "properties": [
          {
            "key": "EntryName",
            "value": "SDRFAMILY"
          }
        ]
      },
      {
        "database": "SUPFAM",
        "id": "SSF51735",
        "properties": [
          {
            "key": "EntryName",
            "value": "NAD(P)-binding Rossmann-fold domains"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      },
      {
        "database": "PROSITE",
        "id": "PS00061",
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          {
            "key": "EntryName",
            "value": "ADH_SHORT"
          },
          {
            "key": "MatchStatus",
            "value": "1"
          }
        ]
      }
    ],
    "sequence": {
      "value": "MEISFRGKRALVTGAGKGIGRATALALARCGSEVTAVTRTKADLDSLVQECPSIKPVCVDLSDWDATKEALNNVGPVDLLVNNAACAKLQPFLDVTPDQFDMSFNINVKAALHVAQIVARGMKARGTGGSIVNVSSQASQCALKDHAVYCATKAALDMLTRVMALELGPHQIRVNSVNPTVVMTEMGKIGWSDPEKARSMTSRIPLGKFAEVEDVVNSILFLLSDKSAMTSGVMLPVDGGFLAC",
      "length": 244,
      "molWeight": 25822,
      "crc64": "FB333497E8326409",
      "md5": "2D0B2F95B187F3B7DE77C08B95885EF9"
    },
    "extraAttributes": {
      "countByCommentType": {
        "SUBUNIT": 1,
        "SIMILARITY": 1
      },
      "countByFeatureType": {
        "Active site": 1
      },
      "uniParcId": "UPI00004F9AE9"
    }
  }
}