id: Q9RSY6
gene_symbol: Q9RSY6
taxon:
  id: NCBITaxon:243230
  label: Deinococcus radiodurans
status: COMPLETE
description: >-
  The bS1 ribosomal-protein architecture supports both predictions, which are less specific than the existing
  curated RNA-binding and ribosomal-subunit annotations.
source_documents:
  - genes/DEIRA/Q9RSY6/Q9RSY6-uniprot.txt
  - genes/DEIRA/Q9RSY6/Q9RSY6-goa.tsv
  - publications/PMID_9451450.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0003676
      label: nucleic acid binding
    predicted_term_type: GO_MF
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The sequence contains multiple S1 RNA-binding domains and is assigned to the bacterial bS1 family.
        Experimental work on E. coli S1 demonstrates RNA binding (PMID:9451450), consistent with the target
        curated IBA for mRNA binding. Nucleic acid binding is a broader molecular function than mRNA binding.
        The prediction is supported but loses the established substrate specificity.
      supported_by:
        - reference_id: file:DEIRA/Q9RSY6/Q9RSY6-uniprot.txt
          supporting_text: >-
            ID   Q9RSY6_DEIRA            Unreviewed;       629 AA. ... DR   GO; GO:0022627; C:cytosolic
            small ribosomal subunit; IBA:GO_Central. ... DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
            ... DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central. ... DR   GO;
            GO:0006412; P:translation; IBA:GO_Central. ... DR   InterPro; IPR050437; Ribos_protein_bS1-like.
            ... DR   InterPro; IPR003029; S1_domain. ... DR   PANTHER; PTHR10724; 30S RIBOSOMAL PROTEIN
            S1; 1. ... DR   PANTHER; PTHR10724:SF7; SMALL RIBOSOMAL SUBUNIT PROTEIN BS1C; 1. ... FT   DOMAIN          122..193
            ... FT                   /note="S1 motif" ... FT   DOMAIN          211..277 ... FT                   /note="S1
            motif" ... FT   DOMAIN          298..366 ... FT                   /note="S1 motif" ... FT   DOMAIN          383..453
            ... FT                   /note="S1 motif" ... FT   DOMAIN          470..539 ... FT                   /note="S1
            motif"
        - reference_id: PMID:9451450
          supporting_text: >-
            The binding of S1 to poly(A) occurred
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005840
      label: ribosome
    predicted_term_type: GO_CC
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target bS1 family assignment and repeated S1-domain architecture support its role in the bacterial
        small ribosomal subunit. This placement is also represented by the curated IBA for cytosolic small
        ribosomal subunit, with the established RNA-binding behavior of S1 providing functional context
        (PMID:9451450). Ribosome is a broader compartment than the annotated subunit. The prediction is
        supported but less precise.
      supported_by:
        - reference_id: file:DEIRA/Q9RSY6/Q9RSY6-uniprot.txt
          supporting_text: >-
            ID   Q9RSY6_DEIRA            Unreviewed;       629 AA. ... DR   GO; GO:0022627; C:cytosolic
            small ribosomal subunit; IBA:GO_Central. ... DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
            ... DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central. ... DR   GO;
            GO:0006412; P:translation; IBA:GO_Central. ... DR   InterPro; IPR050437; Ribos_protein_bS1-like.
            ... DR   InterPro; IPR003029; S1_domain. ... DR   PANTHER; PTHR10724; 30S RIBOSOMAL PROTEIN
            S1; 1. ... DR   PANTHER; PTHR10724:SF7; SMALL RIBOSOMAL SUBUNIT PROTEIN BS1C; 1. ... FT   DOMAIN          122..193
            ... FT                   /note="S1 motif" ... FT   DOMAIN          211..277 ... FT                   /note="S1
            motif" ... FT   DOMAIN          298..366 ... FT                   /note="S1 motif" ... FT   DOMAIN          383..453
            ... FT                   /note="S1 motif" ... FT   DOMAIN          470..539 ... FT                   /note="S1
            motif"
        - reference_id: PMID:9451450
          supporting_text: >-
            The binding of S1 to poly(A) occurred
references:
  - id: file:DEIRA/Q9RSY6/Q9RSY6-uniprot.txt
    title: Q9RSY6-uniprot.txt
  - id: PMID:9451450
    title: Identification of ribosomal protein S1 as a poly(A) binding protein in Escherichia coli.