K9IFT7

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0002227 innate immune response in mucosa	IEA GO_REF:0000118	ACCEPT	Summary: Retain the inferred mucosal innate-defense role of a salivary beta-defensin. Reason: The beta-defensin fold and conserved secretory architecture support an inherited innate effector function. The target transcript was obtained from salivary gland and the native vampirome study reports defensin-family expression in accessory glands, consistent with an oral mucosal context. No lineage-specific loss is established; lack of a purified bat assay does not itself make the inherited term too specific. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt Belongs to the beta-defensin family. PMID:23411029 Accessory glands were enriched with antimicrobials
GO:0005615 extracellular space	IEA GO_REF:0000118	ACCEPT	Summary: Retain extracellular localization of the secreted defensin precursor. Reason: The 1–23 signal peptide and UniProt secretion assignment support the extracellular mature peptide. Extracellular region and extracellular space are compatible; a broad parent is not an erroneous location. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt SUBCELLULAR LOCATION: Secreted
GO:0031731 CCR6 chemokine receptor binding	IEA GO_REF:0000118	KEEP AS NON CORE	Summary: Retain CCR6 binding as a plausible non-core beta-defensin transfer. Reason: The focused OpenScientist defensin report supports DEFB1-like placement well enough to keep the CCR6 TreeGrafter row, but found no direct assay of K9IFT7 or any bat defensin and emphasized that beta-defensin receptor usage varies. Treat the interaction as a low-confidence non-core molecular-function inference rather than as the salivary antimicrobial core. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-hypotheses/defensin-orthology-and-ccr6-binding/openscientist.md the CCR6-binding term is defensible only as a low-confidence, homology-transferred (IEA), non-core molecular function
GO:0050829 defense response to Gram-negative bacterium	IEA GO_REF:0000118	ACCEPT	Summary: Retain the inherited defense response to Gram-negative bacterium. Reason: The secreted beta-defensin 1-like architecture supports the ancestral antimicrobial-spectrum inference, and no target-specific loss of this defense role is established. Human beta-defensin 1 activity can depend strongly on redox conditions, so this term does not assert equal potency against every bacterial species or in every environment. Exact K9IFT7 MICs remain unmeasured. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt Belongs to the beta-defensin family.
GO:0050830 defense response to Gram-positive bacterium	IEA GO_REF:0000118	ACCEPT	Summary: Retain the inherited defense response to Gram-positive bacterium. Reason: The secreted beta-defensin 1-like architecture supports the ancestral antimicrobial-spectrum inference, and no target-specific loss of this defense role is established. Human beta-defensin 1 activity can depend strongly on redox conditions, so this term does not assert equal potency against every bacterial species or in every environment. Exact K9IFT7 MICs remain unmeasured. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt Belongs to the beta-defensin family. PMID:21248850 against anaerobic, Gram-positive commensals of Bifidobacterium and Lactobacillus species.
GO:0005576 extracellular region	IEA GO_REF:0000120	ACCEPT	Summary: Retain extracellular localization of the secreted defensin precursor. Reason: The 1–23 signal peptide and UniProt secretion assignment support the extracellular mature peptide. Extracellular region and extracellular space are compatible; a broad parent is not an erroneous location. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt SUBCELLULAR LOCATION: Secreted
GO:0006952 defense response	IEA GO_REF:0000120	ACCEPT	Summary: Retain the antibacterial defense function. Reason: This is a secreted beta-defensin 1-like peptide from salivary gland. Conserved antimicrobial family function supports defense response and defense response to bacterium; the broader label remains biologically correct. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt Belongs to the beta-defensin family.
GO:0042742 defense response to bacterium	IEA GO_REF:0000043	ACCEPT	Summary: Retain the antibacterial defense function. Reason: This is a secreted beta-defensin 1-like peptide from salivary gland. Conserved antimicrobial family function supports defense response and defense response to bacterium; the broader label remains biologically correct. Supporting Evidence: file:DESRO/K9IFT7/K9IFT7-uniprot.txt Belongs to the beta-defensin family.