K9IWR0

UniProt ID: K9IWR0
Organism: Desmodus rotundus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for K9IWR0

Existing Annotations Review

GO Term Evidence Action Reason
GO:0007165 signal transduction
IEA
GO_REF:0000108 		MARK AS OVER ANNOTATED
Summary: Signal transduction is a broad inference without direct evidence for this DESRO cytokine.
Reason: Annotation is generic and not directly supported in DESRO; core function is cytokine activity.
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
IEA
GO_REF:0000118 		MARK AS OVER ANNOTATED
Summary: Positive regulation of canonical NF-kappaB signaling is a downstream effect inferred from orthology.
Reason: Specific pathway regulation is not directly evidenced for this DESRO protein.
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
IEA
GO_REF:0000118 		MARK AS OVER ANNOTATED
Summary: Positive regulation of extrinsic apoptotic signaling pathway is a downstream inference without direct evidence in DESRO.
Reason: Specific apoptotic pathway regulation is not directly evidenced for this protein.
GO:0005125 cytokine activity
IEA
GO_REF:0000120 		ACCEPT
Summary: UniProt describes this protein as a cytokine that binds TNF receptors.
Reason: UniProt functional description supports cytokine activity.
Supporting Evidence:
file:DESRO/K9IWR0/K9IWR0-uniprot.txt
"Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1"
GO:0005164 tumor necrosis factor receptor binding
IEA
GO_REF:0000120 		ACCEPT
Summary: UniProt functional description indicates TNF receptor binding.
Reason: Functional description notes binding to TNF receptors.
Supporting Evidence:
file:DESRO/K9IWR0/K9IWR0-uniprot.txt
"Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1"
GO:0005576 extracellular region
IEA
GO_REF:0000044 		ACCEPT
Summary: A secreted cytokine; extracellular region is the appropriate location term.
Reason: UniProt indicates secretion; extracellular region is correct. GO has since obsoleted GO:0005615 extracellular space, the replacement previously proposed here, and merged it into GO:0005576 (replaced_by), so this term is now the correct location term.
Supporting Evidence:
file:DESRO/K9IWR0/K9IWR0-uniprot.txt
"SUBCELLULAR LOCATION: Secreted"
GO:0005615 extracellular space
IEA
GO_REF:0000120 		ACCEPT
Summary: UniProt annotates this protein as secreted.
Reason: Secreted localization is supported in UniProt.
Supporting Evidence:
file:DESRO/K9IWR0/K9IWR0-uniprot.txt
"SUBCELLULAR LOCATION: Secreted"
GO:0006955 immune response
IEA
GO_REF:0000002 		MARK AS OVER ANNOTATED
Summary: Immune response is a broad inference without direct evidence in DESRO.
Reason: General immune response annotation is inferred and not directly supported.
GO:0006959 humoral immune response
IEA
GO_REF:0000104 		MARK AS OVER ANNOTATED
Summary: Humoral immune response is a specific process inferred from orthology without direct DESRO evidence.
Reason: Specific humoral response evidence is lacking for this DESRO protein.
GO:0016020 membrane
IEA
GO_REF:0000120 		ACCEPT
Summary: UniProt indicates membrane localization in addition to secretion.
Reason: Subcellular location includes membrane.
Supporting Evidence:
file:DESRO/K9IWR0/K9IWR0-uniprot.txt
"Membrane"

References

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Deep Research

Falcon

(K9IWR0-deep-research-falcon.md)

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📚 Additional Documentation

Notes

(K9IWR0-notes.md)

K9IWR0 Research Notes

Key findings

  • UniProt names this protein lymphotoxin-alpha [file:DESRO/K9IWR0/K9IWR0-uniprot.txt "RecName: Full=Lymphotoxin-alpha"].
  • UniProt indicates the protein is secreted [file:DESRO/K9IWR0/K9IWR0-uniprot.txt "SUBCELLULAR LOCATION: Secreted"].
  • Deep research confirms the identity as lymphotoxin-alpha [file:DESRO/K9IWR0/K9IWR0-deep-research-falcon.md "K9IWR0 is a UniProt accession for lymphotoxin-alpha"]
  • UniProt places this protein in the tumor necrosis factor family [file:DESRO/K9IWR0/K9IWR0-uniprot.txt "Belongs to the tumor necrosis factor family."].

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