K9IYM3

UniProt ID: K9IYM3
Organism: Desmodus rotundus
Review Status: INITIALIZED
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Gene Description

Secreted serpin-like plasma protease C1 inhibitor candidate from vampire bat salivary gland.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0004867 serine-type endopeptidase inhibitor activity
IEA
GO_REF:0000120 		ACCEPT
Summary: Putative plasma protease C1 inhibitor annotation supports serine-type endopeptidase inhibitor activity.
Reason: UniProt classifies this protein as a plasma protease C1 inhibitor (serpin family).
Supporting Evidence:
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"SubName: Full=Putative plasma protease c1 inhibitor"
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"Belongs to the serpin family."
file:DESRO/K9IYM3/K9IYM3-deep-research-falcon.md
K9IYM3 is annotated as a putative plasma protease C1 inhibitor from Desmodus rotundus (common vampire bat), belonging to the serpin superfamily.
GO:0005576 extracellular region
IEA
GO_REF:0000120 		ACCEPT
Summary: Extracellular region is the appropriate localization term for a secreted protein. GO:0005615 (extracellular space) is obsolete.
Reason: UniProt indicates secretion; extracellular region is the correct term since GO:0005615 (extracellular space) is obsolete.
Supporting Evidence:
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"SUBCELLULAR LOCATION: Secreted"
GO:0005615 extracellular space
IEA
GO_REF:0000120 		MODIFY
Summary: GO:0005615 (extracellular space) is obsolete; use GO:0005576 (extracellular region) instead.
Reason: GO:0005615 is obsolete; replace with GO:0005576 (extracellular region).
Proposed replacements: extracellular region
Supporting Evidence:
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"SUBCELLULAR LOCATION: Secreted"
GO:0006508 proteolysis
IEA
GO_REF:0000043 		REMOVE
Summary: Proteolysis is inappropriate for a serpin inhibitor and lacks supporting evidence.
Reason: Serpins inhibit proteases rather than catalyze proteolysis; no evidence for proteolytic activity in this protein.
Supporting Evidence:
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"Belongs to the serpin family."
GO:0007596 blood coagulation
IEA
GO_REF:0000043 		MARK AS OVER ANNOTATED
Summary: Blood coagulation annotation is inferred from keywords without direct evidence in DESRO.
Reason: No experimental evidence for this specific process in DESRO K9IYM3; annotation is keyword-based.
GO:0007599 hemostasis
IEA
GO_REF:0000043 		MARK AS OVER ANNOTATED
Summary: Hemostasis annotation is broad and inferred without direct evidence for this DESRO protein.
Reason: Keyword-based inference lacks direct experimental support.
GO:0008233 peptidase activity
IEA
GO_REF:0000043 		REMOVE
Summary: Peptidase activity is inconsistent with a serpin inhibitor and lacks evidence.
Reason: This protein is annotated as a protease inhibitor rather than an enzyme.
Supporting Evidence:
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"Belongs to the serpin family."
GO:0030414 peptidase inhibitor activity
IEA
GO_REF:0000043 		MODIFY
Summary: Peptidase inhibitor activity is a broad parent term; use the specific serine-type endopeptidase inhibitor activity.
Reason: Serpin annotation supports serine-type endopeptidase inhibitor activity.
Supporting Evidence:
file:DESRO/K9IYM3/K9IYM3-uniprot.txt
"Belongs to the serpin family."
GO:0042730 fibrinolysis
IEA
GO_REF:0000043 		MARK AS OVER ANNOTATED
Summary: Fibrinolysis annotation is inferred without direct evidence for this DESRO protein.
Reason: Keyword-based inference lacks experimental support in DESRO.

Core Functions

Secreted serpin-family protease inhibitor (plasma protease C1 inhibitor-like).

Molecular Function:
serine-type endopeptidase inhibitor activity
Cellular Locations:
extracellular region
Supporting Evidence:
  • file:DESRO/K9IYM3/K9IYM3-uniprot.txt
    SubName: Full=Putative plasma protease c1 inhibitor
  • file:DESRO/K9IYM3/K9IYM3-uniprot.txt
    Belongs to the serpin family.
  • file:DESRO/K9IYM3/K9IYM3-uniprot.txt
    SUBCELLULAR LOCATION: Secreted
  • file:DESRO/K9IYM3/K9IYM3-deep-research-falcon.md
    K9IYM3 is annotated as a putative plasma protease C1 inhibitor from Desmodus rotundus (common vampire bat), belonging to the serpin superfamily.

References

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Deep Research

Falcon

(K9IYM3-deep-research-falcon.md)

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📚 Additional Documentation

Notes

(K9IYM3-notes.md)

K9IYM3 Research Notes

Key findings

  • UniProt annotates this protein as a putative plasma protease C1 inhibitor [file:DESRO/K9IYM3/K9IYM3-uniprot.txt "SubName: Full=Putative plasma protease c1 inhibitor"].
  • UniProt indicates the protein is secreted [file:DESRO/K9IYM3/K9IYM3-uniprot.txt "SUBCELLULAR LOCATION: Secreted"].
  • UniProt places the protein in the serpin family [file:DESRO/K9IYM3/K9IYM3-uniprot.txt "Belongs to the serpin family."].
  • Deep research summary notes the Desmodus rotundus serpin annotation [file:DESRO/K9IYM3/K9IYM3-deep-research-falcon.md "K9IYM3 is annotated as a putative plasma protease C1 inhibitor from Desmodus rotundus (common vampire bat), belonging to the serpin superfamily."].

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