Kunitz-type serine protease inhibitor expressed in salivary gland; single-pass membrane protein with predicted inhibitor function.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004867 serine-type endopeptidase inhibitor activity | IEA GO_REF:0000120 | ACCEPT | Summary: Kunitz-type inhibitor annotation supports serine-type endopeptidase inhibitor activity. Reason: UniProt describes this protein as a Kunitz-type protease inhibitor. Supporting Evidence: file:DESRO/K9IZA2/K9IZA2-uniprot.txt "RecName: Full=Kunitz-type protease inhibitor 2" file:DESRO/K9IZA2/K9IZA2-deep-research-falcon.md Protein class: HAI-2/SPINT2 is a Kunitz-type serine protease inhibitor, typically a membrane-associated glycoprotein with one or more Kunitz domains that can also be shed to yield soluble forms. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: UniProt annotates cytoplasmic localization. Reason: Subcellular location includes cytoplasm in the UniProt record. Supporting Evidence: file:DESRO/K9IZA2/K9IZA2-uniprot.txt "Cytoplasm" |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: UniProt annotates cell membrane localization for this single-pass protein. Reason: Subcellular location includes cell membrane. Supporting Evidence: file:DESRO/K9IZA2/K9IZA2-uniprot.txt "SUBCELLULAR LOCATION: Cell membrane" file:DESRO/K9IZA2/K9IZA2-deep-research-falcon.md Protein class: HAI-2/SPINT2 is a Kunitz-type serine protease inhibitor, typically a membrane-associated glycoprotein with one or more Kunitz domains that can also be shed to yield soluble forms. |
| GO:0030414 peptidase inhibitor activity | IEA GO_REF:0000043 | MODIFY | Summary: Peptidase inhibitor activity is a broad parent term; a more specific serine-type endopeptidase inhibitor term is appropriate. Reason: Use the specific Kunitz-type serine protease inhibitor activity already supported by the UniProt name. Proposed replacements: serine-type endopeptidase inhibitor activity Supporting Evidence: file:DESRO/K9IZA2/K9IZA2-uniprot.txt "RecName: Full=Kunitz-type protease inhibitor 2" |
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