K9J287

UniProt ID: K9J287
Organism: Desmodus rotundus
Review Status: INITIALIZED
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Gene Description

DNase I-like 1 fragment from vampire bat salivary gland; predicted nuclease with ER localization.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0003677 DNA binding
IEA
GO_REF:0000118 		MARK AS OVER ANNOTATED
Summary: DNA binding is a generic inference for a DNase I-like protein and may be over-annotated without direct evidence.
Reason: Annotation is inferred from domain/TreeGrafter without direct experimental evidence.
GO:0004530 deoxyribonuclease I activity
IEA
GO_REF:0000118 		ACCEPT
Summary: DNase I-like annotation supports deoxyribonuclease I activity.
Reason: UniProt names this protein deoxyribonuclease-1-like 1, consistent with DNase I activity.
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"
file:DESRO/K9J287/K9J287-deep-research-falcon.md
The UniProt accession K9J287 provided corresponds to a protein annotated as a deoxyribonuclease I-like 1 (DNASE1L1; also known as DNase X) fragment in Desmodus rotundus (vampire bat), belonging to the DNase I family
GO:0005634 nucleus
IEA
GO_REF:0000118 		REMOVE
Summary: Nuclear localization is not supported by UniProt, which indicates ER localization.
Reason: UniProt subcellular location indicates endoplasmic reticulum, not nucleus.
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"SUBCELLULAR LOCATION: Endoplasmic reticulum"
GO:0003824 catalytic activity
IEA
GO_REF:0000002 		MODIFY
Summary: Catalytic activity is too general for this DNase I-like protein.
Reason: Use the specific deoxyribonuclease I activity term.
Proposed replacements: deoxyribonuclease I activity
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"
GO:0004518 nuclease activity
IEA
GO_REF:0000120 		MODIFY
Summary: Nuclease activity is a broad parent term for DNase I activity.
Reason: Use the specific deoxyribonuclease I activity term.
Proposed replacements: deoxyribonuclease I activity
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"
GO:0004519 endonuclease activity
IEA
GO_REF:0000043 		MODIFY
Summary: Endonuclease activity is a broad parent term for DNase I activity.
Reason: Use the specific deoxyribonuclease I activity term.
Proposed replacements: deoxyribonuclease I activity
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"
GO:0004536 DNA nuclease activity
IEA
GO_REF:0000002 		MODIFY
Summary: DNA nuclease activity is a broad parent term for DNase I activity.
Reason: Use the specific deoxyribonuclease I activity term.
Proposed replacements: deoxyribonuclease I activity
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"
GO:0005783 endoplasmic reticulum
IEA
GO_REF:0000044 		ACCEPT
Summary: UniProt annotates endoplasmic reticulum localization.
Reason: Subcellular location indicates ER.
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"SUBCELLULAR LOCATION: Endoplasmic reticulum"
GO:0006259 DNA metabolic process
IEA
GO_REF:0000117 		MODIFY
Summary: DNA metabolic process is broad; the more specific DNA catabolic process is appropriate for DNase activity.
Reason: Use the specific DNA catabolic process term already present.
Proposed replacements: DNA catabolic process
GO:0006308 DNA catabolic process
IEA
GO_REF:0000120 		ACCEPT
Summary: DNase I-like activity supports DNA catabolic process.
Reason: DNase activity implies DNA catabolism.
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"
GO:0016787 hydrolase activity
IEA
GO_REF:0000043 		MODIFY
Summary: Hydrolase activity is too general for a DNase I-like protein.
Reason: Use the specific deoxyribonuclease I activity term.
Proposed replacements: deoxyribonuclease I activity
Supporting Evidence:
file:DESRO/K9J287/K9J287-uniprot.txt
"RecName: Full=Deoxyribonuclease-1-like 1"

Core Functions

DNase I-like nuclease activity contributing to DNA catabolism; predicted ER localization.

Molecular Function:
deoxyribonuclease I activity
Directly Involved In:
DNA catabolic process
Cellular Locations:
endoplasmic reticulum
Supporting Evidence:
  • file:DESRO/K9J287/K9J287-uniprot.txt
    RecName: Full=Deoxyribonuclease-1-like 1
  • file:DESRO/K9J287/K9J287-uniprot.txt
    SUBCELLULAR LOCATION: Endoplasmic reticulum
  • file:DESRO/K9J287/K9J287-deep-research-falcon.md
    The UniProt accession K9J287 provided corresponds to a protein annotated as a deoxyribonuclease I-like 1 (DNASE1L1; also known as DNase X) fragment in Desmodus rotundus (vampire bat), belonging to the DNase I family

References

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Deep Research

Falcon

(K9J287-deep-research-falcon.md)

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📚 Additional Documentation

Notes

(K9J287-notes.md)

K9J287 Research Notes

Key findings

  • UniProt names this protein deoxyribonuclease-1-like 1 [file:DESRO/K9J287/K9J287-uniprot.txt "RecName: Full=Deoxyribonuclease-1-like 1"].
  • UniProt subcellular location indicates endoplasmic reticulum [file:DESRO/K9J287/K9J287-uniprot.txt "SUBCELLULAR LOCATION: Endoplasmic reticulum"].
  • Deep research summary links the accession to DNASE1L1/DNase X and the DNase I family [file:DESRO/K9J287/K9J287-deep-research-falcon.md "The UniProt accession K9J287 provided corresponds to a protein annotated as a deoxyribonuclease I-like 1 (DNASE1L1; also known as DNase X) fragment in Desmodus rotundus (vampire bat), belonging to the DNase I family"].
  • Deep research summary notes limited species-specific literature [file:DESRO/K9J287/K9J287-deep-research-falcon.md "Specific primary literature on DNASE1L1 from Desmodus rotundus is limited."].

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