TODO: Add description for K9J2R0
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IEA GO_REF:0000118 | ACCEPT | Summary: Plasma membrane localization is supported by UniProt subcellular location annotations. Reason: UniProt lists apical cell membrane and other membrane localizations. Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "SUBCELLULAR LOCATION: Apical cell membrane" |
| GO:0004177 aminopeptidase activity | IEA GO_REF:0000043 | MODIFY | Summary: Aminopeptidase activity is a broad parent term; dipeptidyl-peptidase activity is the specific function. Reason: Use the specific dipeptidyl-peptidase activity term supported by UniProt catalytic description. Proposed replacements: dipeptidyl-peptidase activity Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0004252 serine-type endopeptidase activity | IEA GO_REF:0000002 | MODIFY | Summary: Serine-type endopeptidase activity is too general; the specific dipeptidyl-peptidase activity is appropriate. Reason: DPP4 is a dipeptidyl peptidase (EC 3.4.14.5). Proposed replacements: dipeptidyl-peptidase activity Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Secretion is noted, so extracellular region is defensible, but the main localization is membrane. Reason: UniProt notes a secreted form, so extracellular region is defensible, but the main localization is membrane/apical membrane. GO has since obsoleted GO:0005615 extracellular space, the replacement previously proposed here, and merged it into GO:0005576 (replaced_by), so this term is now the correct location term. Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Secreted" |
| GO:0006508 proteolysis | IEA GO_REF:0000120 | MODIFY | Summary: Proteolysis is a broad parent term; dipeptidyl-peptidase activity is more specific. Reason: Use the specific dipeptidyl-peptidase activity term. Proposed replacements: dipeptidyl-peptidase activity Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0007155 cell adhesion | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Cell adhesion is an inferred keyword-based annotation without direct evidence in DESRO. Reason: No direct experimental evidence for cell adhesion function in DESRO DPP4. |
| GO:0008233 peptidase activity | IEA GO_REF:0000043 | MODIFY | Summary: Peptidase activity is a broad parent term; dipeptidyl-peptidase activity is more specific. Reason: Use the specific dipeptidyl-peptidase activity term. Proposed replacements: dipeptidyl-peptidase activity Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0008236 serine-type peptidase activity | IEA GO_REF:0000120 | MODIFY | Summary: Serine-type peptidase activity is too general; DPP4 is a dipeptidyl peptidase. Reason: Use the specific dipeptidyl-peptidase activity term. Proposed replacements: dipeptidyl-peptidase activity Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0008239 dipeptidyl-peptidase activity | IEA GO_REF:0000120 | ACCEPT | Summary: UniProt catalytic description supports dipeptidyl-peptidase activity. Reason: UniProt describes DPP4 reaction releasing N-terminal dipeptides. Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0016324 apical plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Apical plasma membrane localization is supported by UniProt subcellular location. Reason: UniProt lists apical cell membrane localization. Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "SUBCELLULAR LOCATION: Apical cell membrane" |
| GO:0016787 hydrolase activity | IEA GO_REF:0000043 | MODIFY | Summary: Hydrolase activity is too general; dipeptidyl-peptidase activity is more specific. Reason: Use the specific dipeptidyl-peptidase activity term. Proposed replacements: dipeptidyl-peptidase activity Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Reaction=Release of an N-terminal dipeptide" |
| GO:0031258 lamellipodium membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Lamellipodium membrane localization is listed in UniProt subcellular location. Reason: UniProt subcellular location includes lamellipodium membrane. Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Cell projection, lamellipodium membrane" |
| GO:0042995 cell projection | IEA GO_REF:0000044 | MODIFY | Summary: Cell projection is a broad parent term; lamellipodium membrane provides specific localization. Reason: Use lamellipodium membrane instead of the general cell projection term. Proposed replacements: lamellipodium membrane Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Cell projection, lamellipodium membrane" |
| GO:0045121 membrane raft | IEA GO_REF:0000044 | ACCEPT | Summary: Membrane raft localization is listed in UniProt subcellular location. Reason: UniProt subcellular location includes membrane raft. Supporting Evidence: file:DESRO/K9J2R0/K9J2R0-uniprot.txt "Membrane raft" |
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