Protein kinase B (Akt) that transduces PI3K signals to control growth, metabolism, survival, and development.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004674 protein serine/threonine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes file:genes/DROME/Akt1/Akt1-deep-research-falcon.md RecName: Full=RAC serine/threonine-protein kinase |
| GO:0035556 intracellular signal transduction | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Akt1 participates in intracellular signal transduction. Reason: Akt1 is a core kinase in insulin/PI3K signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway |
| GO:0043066 negative regulation of apoptotic process | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Akt1 negatively regulates apoptosis. Reason: Akt1 is described as a survival protein and dephosphorylation triggers apoptosis. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt During early embryogenesis, acts as a survival protein file:genes/DROME/Akt1/Akt1-uniprot.txt Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth |
| GO:0008286 insulin receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway |
| GO:0043536 positive regulation of blood vessel endothelial cell migration | IBA GO_REF:0000033 | MARK AS OVER ANNOTATED | Summary: Blood vessel endothelial cell migration is not applicable to Drosophila Akt1. Reason: Drosophila lacks vascular endothelium; this term is too specific for fly Akt1. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: Akt1 binds nucleotides as part of its kinase reaction. Reason: The catalytic reaction uses ATP, indicating nucleotide binding. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Akt1 has protein kinase activity. Reason: Catalytic activity confirms protein kinase function. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Akt1 uses ATP in its catalytic reaction. Reason: The kinase reaction explicitly consumes ATP. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0005829 cytosol | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Akt1 can localize to the plasma membrane upon activation. Reason: UniProt notes membrane recruitment upon activation. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0006915 apoptotic process | IEA GO_REF:0000043 | MODIFY | Summary: Akt1 regulates apoptosis rather than executing apoptotic processes. Reason: Akt1 functions as a survival protein and opposes apoptosis; use regulation term. Proposed replacements: negative regulation of apoptotic process Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt During early embryogenesis, acts as a survival protein |
| GO:0008286 insulin receptor signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway |
| GO:0008582 regulation of synaptic assembly at neuromuscular junction | IEA GO_REF:0000117 | UNDECIDED | Summary: Regulation of synaptic assembly at the NMJ is not clearly supported for Akt1. Reason: No direct NMJ synaptic assembly evidence for Akt1 was found in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway |
| GO:0016301 kinase activity | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: Akt1 has kinase activity. Reason: Catalytic activity confirms kinase function. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: Akt1 is a transferase (kinase) enzyme. Reason: Kinases transfer phosphate groups from ATP. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | KEEP AS NON CORE | Summary: Akt1 has protein serine kinase activity. Reason: Akt1 is a serine/threonine kinase. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes |
| GO:0005515 protein binding | IPI PMID:24068890 A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K... | KEEP AS NON CORE | Summary: Akt1 interacts with protein partners such as Trbl. Reason: UniProt reports interaction with Trbl, supporting protein binding. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Interacts with trbl. PMID:24068890 A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. |
| GO:0005515 protein binding | IPI PMID:24413555 The SCFSlimb E3 ligase complex regulates asymmetric division... | KEEP AS NON CORE | Summary: Akt1 interacts with protein partners such as Trbl. Reason: UniProt reports interaction with Trbl, supporting protein binding. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Interacts with trbl. PMID:24413555 The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-DME-110475 | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-DME-169828 | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:20585550 Dynamic switch of negative feedback regulation in Drosophila... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:20585550 Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:36730473 A genetic strategy to measure insulin signaling regulation a... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:36730473 A genetic strategy to measure insulin signaling regulation and physiology in Drosophila. |
| GO:0043524 negative regulation of neuron apoptotic process | IGI PMID:24916379 Genetic dissection reveals that Akt is the critical kinase d... | KEEP AS NON CORE | Summary: Akt1 promotes neuron survival. Reason: Akt is described as promoting neuron survival downstream of LRRK2. Supporting Evidence: PMID:24916379 Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IGI PMID:34751396 Pvr and distinct downstream signaling factors are required f... | MARK AS OVER ANNOTATED | Summary: VEGF receptor signaling pathway is not directly supported for Drosophila Akt1. Reason: No direct VEGF receptor signaling evidence was identified for Akt1 in available sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:34751396 Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites. |
| GO:0044319 wound healing, spreading of cells | IGI PMID:34751396 Pvr and distinct downstream signaling factors are required f... | UNDECIDED | Summary: Wound healing, spreading of cells is not directly supported by accessible Akt1 evidence. Reason: No direct evidence for wound healing roles of Akt1 was identified in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:34751396 Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites. |
| GO:0030307 positive regulation of cell growth | IMP PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. | KEEP AS NON CORE | Summary: Akt1 promotes cell growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls cell growth. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:12893776 Control of cell number by Drosophila FOXO: downstream and fe... | KEEP AS NON CORE | Summary: Akt1 promotes cell population proliferation through growth signaling. Reason: Insulin receptor signaling regulated by Akt1 promotes growth and organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:12893776 Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. |
| GO:0030307 positive regulation of cell growth | IMP PMID:17462592 Discrete functions of rictor and raptor in cell growth regul... | KEEP AS NON CORE | Summary: Akt1 promotes cell growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls cell growth. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:17462592 Discrete functions of rictor and raptor in cell growth regulation in Drosophila. |
| GO:0030307 positive regulation of cell growth | IMP PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signali... | KEEP AS NON CORE | Summary: Akt1 promotes cell growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls cell growth. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation. |
| GO:0035206 regulation of hemocyte proliferation | IMP PMID:20688956 Genetic manipulation of AML1-ETO-induced expansion of hemato... | UNDECIDED | Summary: Hemocyte proliferation regulation is not supported by accessible Akt-specific evidence. Reason: The cited study does not directly mention Akt in hemocyte proliferation in the abstract. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:20688956 Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. |
| GO:0035264 multicellular organism growth | IMP PMID:21464442 Drosophila insulin pathway mutants affect visual physiology ... | KEEP AS NON CORE | Summary: Akt1 contributes to multicellular organism growth. Reason: Insulin receptor signaling regulated by Akt1 controls growth and organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:21464442 Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. |
| GO:0040014 regulation of multicellular organism growth | IMP PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | KEEP AS NON CORE | Summary: Akt1 regulates multicellular organism growth via insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls growth and organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0040018 positive regulation of multicellular organism growth | IGI PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signali... | KEEP AS NON CORE | Summary: Akt1 positively regulates multicellular organism growth. Reason: Insulin receptor signaling regulated by Akt1 controls growth and organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation. |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:9601646 Genetic analysis of protein kinase B (AKT) in Drosophila. | KEEP AS NON CORE | Summary: Akt1 negatively regulates apoptosis. Reason: Akt1 is described as a survival protein and dephosphorylation triggers apoptosis. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt During early embryogenesis, acts as a survival protein file:genes/DROME/Akt1/Akt1-uniprot.txt Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth PMID:9601646 Genetic analysis of protein kinase B (AKT) in Drosophila. |
| GO:0045793 positive regulation of cell size | IMP PMID:10587646 Cell-autonomous regulation of cell and organ growth in Droso... | KEEP AS NON CORE | Summary: Akt1 promotes cell size via insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls growth and size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10587646 Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. |
| GO:0045793 positive regulation of cell size | IMP PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | KEEP AS NON CORE | Summary: Akt1 promotes cell size via insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls growth and size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0045793 positive regulation of cell size | IMP PMID:19216764 PDGF/VEGF signaling controls cell size in Drosophila. | KEEP AS NON CORE | Summary: Akt1 promotes cell size via insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls growth and size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:19216764 PDGF/VEGF signaling controls cell size in Drosophila. |
| GO:0046622 positive regulation of organ growth | IMP PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | KEEP AS NON CORE | Summary: Akt1 promotes organ growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:1904263 positive regulation of TORC1 signaling | IMP PMID:28829944 Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F... | KEEP AS NON CORE | Summary: Akt1 can promote TORC1 signaling via Tsc2 inhibition. Reason: UniProt notes Akt1 may stimulate growth by inactivating the Tsc complex. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex PMID:28829944 Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:32998936 Meep, a Novel Regulator of Insulin Signaling, Supports Devel... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:32998936 Meep, a Novel Regulator of Insulin Signaling, Supports Development and Insulin Sensitivity via Maintenance of Protein Homeostasis in Drosophila melanogaster. |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:31613895 The Hippo pathway integrates PI3K-Akt signals with mechanica... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:31613895 The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. |
| GO:0035331 negative regulation of hippo signaling | IMP PMID:31613895 The Hippo pathway integrates PI3K-Akt signals with mechanica... | MARK AS OVER ANNOTATED | Summary: Negative regulation of Hippo signaling is not directly supported for Akt1. Reason: The cited Hippo study shows IIS/PI3K/PDK1/Akt inputs but not specific negative regulation by Akt. Supporting Evidence: PMID:31613895 via phosphatidyl inositol-3-kinase (PI3K), phosphoinositide-dependent kinase 1 (PDK1 or PDPK1), and protein kinase B (Akt or PKB) |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IDA PMID:18000865 Gliatrophic and gliatropic roles of PVF/PVR signaling during... | MARK AS OVER ANNOTATED | Summary: VEGF receptor signaling pathway is not directly supported for Drosophila Akt1. Reason: No direct VEGF receptor signaling evidence was identified for Akt1 in available sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:18000865 Gliatrophic and gliatropic roles of PVF/PVR signaling during axon guidance. |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. | KEEP AS NON CORE | Summary: Akt1 is a central kinase in PI3K/PKB signal transduction. Reason: Akt1 operates downstream of PI3K in insulin signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signali... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:29514084 Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation. |
| GO:1903688 positive regulation of border follicle cell migration | IGI PMID:29950391 Insulin signaling modulates border cell movement in Drosophi... | KEEP AS NON CORE | Summary: Insulin signaling modulates border cell migration in oogenesis. Reason: Insulin signaling regulates border cell movement during oogenesis. Supporting Evidence: PMID:29950391 insulin signaling modulates collective BC movement during Drosophila oogenesis |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but ... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but ... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. |
| GO:0032869 cellular response to insulin stimulus | IDA PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but ... | KEEP AS NON CORE | Summary: Akt1 mediates cellular responses to insulin. Reason: Akt1 acts downstream of insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:11862217 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:29045833 Intestinal Fork Head Regulates Nutrient Absorption and Promo... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:29045833 Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. |
| GO:0055088 lipid homeostasis | IMP PMID:21464442 Drosophila insulin pathway mutants affect visual physiology ... | KEEP AS NON CORE | Summary: Lipid homeostasis involvement is supported through Akt-dependent lipid storage regulation. Reason: Activated Akt affects lipid droplet accumulation in nurse cells. Supporting Evidence: PMID:17079271 accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2 PMID:21464442 Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:22242005 MAPK/ERK signaling regulates insulin sensitivity to control ... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:22242005 MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IMP PMID:25749252 A systems-level interrogation identifies regulators of Droso... | MARK AS OVER ANNOTATED | Summary: VEGF receptor signaling pathway is not directly supported for Drosophila Akt1. Reason: No direct VEGF receptor signaling evidence was identified for Akt1 in available sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:25749252 A systems-level interrogation identifies regulators of Drosophila blood cell number and survival. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IGI PMID:19216764 PDGF/VEGF signaling controls cell size in Drosophila. | MARK AS OVER ANNOTATED | Summary: VEGF receptor signaling pathway is not directly supported for Drosophila Akt1. Reason: No direct VEGF receptor signaling evidence was identified for Akt1 in available sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:19216764 PDGF/VEGF signaling controls cell size in Drosophila. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:21565616 A hormone-dependent module regulating energy balance. | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:21565616 A hormone-dependent module regulating energy balance. |
| GO:0005829 cytosol | IDA PMID:18827008 The protein phosphatase PP2A-B' subunit Widerborst is a nega... | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. PMID:18827008 The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:14645523 Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:14645523 Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. |
| GO:0010884 positive regulation of lipid storage | IMP PMID:18827008 The protein phosphatase PP2A-B' subunit Widerborst is a nega... | KEEP AS NON CORE | Summary: Activated Akt promotes lipid storage in nurse cells. Reason: Activated Akt increases LSD2 expression linked to lipid droplet accumulation. Supporting Evidence: PMID:17079271 accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2 PMID:18827008 The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:17183368 Insulin delays the progression of Drosophila cells through G... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:17183368 Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. |
| GO:0010897 negative regulation of triglyceride catabolic process | IMP PMID:21565616 A hormone-dependent module regulating energy balance. | KEEP AS NON CORE | Summary: Akt1 promotes lipid storage, consistent with reduced triglyceride catabolism. Reason: Activated Akt increases lipid storage markers. Supporting Evidence: PMID:17079271 accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2 PMID:21565616 A hormone-dependent module regulating energy balance. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:17369395 Re-evaluating AKT regulation: role of TOR complex 2 in tissu... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:17369395 Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:17369395 Re-evaluating AKT regulation: role of TOR complex 2 in tissu... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:17369395 Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. |
| GO:0032869 cellular response to insulin stimulus | IDA PMID:17369395 Re-evaluating AKT regulation: role of TOR complex 2 in tissu... | KEEP AS NON CORE | Summary: Akt1 mediates cellular responses to insulin. Reason: Akt1 acts downstream of insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:17369395 Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:12893776 Control of cell number by Drosophila FOXO: downstream and fe... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:12893776 Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:15337530 Drosophila PI3 kinase and Akt involved in insulin-stimulated... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:15337530 Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:7876156 Developmental regulation of expression and activity of multi... | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:7876156 Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. |
| GO:0005634 nucleus | IDA PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-dro... | UNDECIDED | Summary: Nuclear localization is not supported by the UniProt subcellular location statement. Reason: UniProt lists cytosol/cell membrane, not nuclear localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. |
| GO:0005829 cytosol | IDA PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-dro... | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. |
| GO:0005938 cell cortex | IDA PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-dro... | UNDECIDED | Summary: Cell cortex localization is not supported by available sources for Akt1. Reason: No direct evidence for cortical localization was identified in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. |
| GO:0008286 insulin receptor signaling pathway | IMP PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:12172554 Akt regulates growth by directly phosphorylating Tsc2. |
| GO:0010884 positive regulation of lipid storage | IGI PMID:17079271 Cytoplasmic activated protein kinase Akt regulates lipid-dro... | KEEP AS NON CORE | Summary: Activated Akt promotes lipid storage in nurse cells. Reason: Activated Akt increases LSD2 expression linked to lipid droplet accumulation. Supporting Evidence: PMID:17079271 accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2 |
| GO:0042632 cholesterol homeostasis | IMP PMID:27326933 A Drosophila Genome-Wide Screen Identifies Regulators of Ste... | UNDECIDED | Summary: Cholesterol homeostasis is not directly supported by accessible evidence. Reason: Available sources focus on insulin signaling and lipid storage rather than cholesterol homeostasis. Supporting Evidence: PMID:17079271 accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2 PMID:27326933 A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing. |
| GO:0005829 cytosol | TAS Reactome:R-DME-110463 | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0005829 cytosol | TAS Reactome:R-DME-110468 | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0005829 cytosol | TAS Reactome:R-DME-110475 | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0005829 cytosol | TAS Reactome:R-DME-169828 | KEEP AS NON CORE | Summary: Akt1 localizes to the cytosol/cytoplasm. Reason: UniProt reports cytosolic and cytoplasmic localization. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0005886 plasma membrane | TAS Reactome:R-DME-110463 | KEEP AS NON CORE | Summary: Akt1 can localize to the plasma membrane upon activation. Reason: UniProt notes membrane recruitment upon activation. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0005886 plasma membrane | TAS Reactome:R-DME-110468 | KEEP AS NON CORE | Summary: Akt1 can localize to the plasma membrane upon activation. Reason: UniProt notes membrane recruitment upon activation. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. |
| GO:0090278 negative regulation of peptide hormone secretion | IMP PMID:25101872 A genetic strategy to measure circulating Drosophila insulin... | UNDECIDED | Summary: Negative regulation of peptide hormone secretion is not supported by accessible Akt1 evidence. Reason: No direct evidence for Akt1 in peptide hormone secretion was identified in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:25101872 A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion. |
| GO:0048477 oogenesis | IMP PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive res... | KEEP AS NON CORE | Summary: Akt1 functions in oogenesis by controlling follicle cell size. Reason: UniProt reports control of follicle cell size during oogenesis. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Controls follicle cell size during oogenesis PMID:24786828 The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. |
| GO:0043025 neuronal cell body | IDA PMID:24068890 A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K... | UNDECIDED | Summary: Neuronal cell body localization is not supported by accessible sources. Reason: No direct neuronal cell body localization evidence was identified in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation. PMID:24068890 A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. |
| GO:0045886 negative regulation of synaptic assembly at neuromuscular junction | IMP PMID:23393158 Tuberous sclerosis complex regulates Drosophila neuromuscula... | UNDECIDED | Summary: Negative regulation of synaptic assembly at the NMJ is not clearly supported for Akt1. Reason: No direct NMJ synaptic assembly evidence for Akt1 was found in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:23393158 Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway. |
| GO:0031104 dendrite regeneration | IMP PMID:22759636 Regeneration of Drosophila sensory neuron axons and dendrite... | KEEP AS NON CORE | Summary: Akt pathway promotes dendrite regeneration. Reason: Akt pathway activity affects dendrite regeneration in sensory neurons. Supporting Evidence: PMID:22759636 dendrite regeneration is restrained via inhibition of the Akt pathway |
| GO:0048680 positive regulation of axon regeneration | IMP PMID:22759636 Regeneration of Drosophila sensory neuron axons and dendrite... | KEEP AS NON CORE | Summary: Akt pathway activation enhances axon regeneration. Reason: Akt activation enhances axon regeneration in the CNS. Supporting Evidence: PMID:22759636 activating the Akt pathway enhances axon regeneration in the CNS |
| GO:0005515 protein binding | IPI PMID:15808505 PHLPP: a phosphatase that directly dephosphorylates Akt, pro... | KEEP AS NON CORE | Summary: Akt1 interacts with protein partners such as Trbl. Reason: UniProt reports interaction with Trbl, supporting protein binding. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Interacts with trbl. PMID:15808505 PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. |
| GO:0006979 response to oxidative stress | IMP PMID:17895391 FOXO and insulin signaling regulate sensitivity of the circa... | KEEP AS NON CORE | Summary: Akt influences circadian clock sensitivity to oxidative stress. Reason: Akt overexpression increases susceptibility of the central clock to oxidative stress. Supporting Evidence: PMID:17895391 such as the insulin receptor or Akt, in the fat body also increased susceptibility of the central clock to oxidative stress. |
| GO:0007623 circadian rhythm | IMP PMID:17895391 FOXO and insulin signaling regulate sensitivity of the circa... | KEEP AS NON CORE | Summary: Akt impacts circadian rhythm via insulin/FOXO signaling. Reason: Akt overexpression affects central clock function under oxidative stress. Supporting Evidence: PMID:17895391 such as the insulin receptor or Akt, in the fat body also increased susceptibility of the central clock to oxidative stress. |
| GO:0060292 long-term synaptic depression | IMP PMID:16611817 Requirement of Akt to mediate long-term synaptic depression ... | UNDECIDED | Summary: Long-term synaptic depression is not supported by accessible Akt1-specific evidence. Reason: No direct evidence for Akt1 in long-term synaptic depression was identified in accessible sources. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:16611817 Requirement of Akt to mediate long-term synaptic depression in Drosophila. |
| GO:0050773 regulation of dendrite development | IMP PMID:19778508 The microRNA bantam functions in epithelial cells to regulat... | KEEP AS NON CORE | Summary: Akt activity influences dendrite development. Reason: Akt kinase activity in neurons influences dendrite growth. Supporting Evidence: PMID:19778508 ban in epithelial cells dampens Akt kinase activity in adjacent neurons to influence dendrite growth |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:9601646 Genetic analysis of protein kinase B (AKT) in Drosophila. | ACCEPT | Summary: Akt1 is a serine/threonine protein kinase. Reason: UniProt describes Akt1 as a serine/threonine kinase involved in developmental processes. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Serine/threonine kinase involved in various developmental processes PMID:9601646 Genetic analysis of protein kinase B (AKT) in Drosophila. |
| GO:0007424 open tracheal system development | IMP PMID:11740943 Regulation of Drosophila tracheal system development by prot... | KEEP AS NON CORE | Summary: Akt1 regulates tracheal development by activating Trh. Reason: Akt1 phosphorylates Trh required for tracheal cell fate. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination PMID:11740943 Regulation of Drosophila tracheal system development by protein kinase B. |
| GO:0007427 epithelial cell migration, open tracheal system | IMP PMID:14525946 Coordinated functions of Akt/PKB and ETS1 in tubule formatio... | KEEP AS NON CORE | Summary: Akt1 regulates tracheal cell migration. Reason: UniProt notes Akt1 regulates tracheal cell migration. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt Also regulates tracheal cell migration PMID:14525946 Coordinated functions of Akt/PKB and ETS1 in tubule formation. |
| GO:0008284 positive regulation of cell population proliferation | IMP NOT PMID:10587646 Cell-autonomous regulation of cell and organ growth in Droso... | KEEP AS NON CORE | Summary: Akt1 promotes cell population proliferation through growth signaling. Reason: Insulin receptor signaling regulated by Akt1 promotes growth and organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10587646 Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. |
| GO:0008286 insulin receptor signaling pathway | IDA PMID:10587646 Cell-autonomous regulation of cell and organ growth in Droso... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:10587646 Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. |
| GO:0008286 insulin receptor signaling pathway | IGI PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | ACCEPT | Summary: Akt1 acts in the insulin receptor signaling pathway. Reason: UniProt states Akt1 functions downstream of PI3K/PDK1 in insulin receptor signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0030307 positive regulation of cell growth | IMP PMID:10587646 Cell-autonomous regulation of cell and organ growth in Droso... | KEEP AS NON CORE | Summary: Akt1 promotes cell growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls cell growth. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10587646 Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. |
| GO:0030307 positive regulation of cell growth | IMP PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | KEEP AS NON CORE | Summary: Akt1 promotes cell growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls cell growth. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0030307 positive regulation of cell growth | IMP PMID:15712201 dAkt kinase controls follicle cell size during Drosophila oo... | KEEP AS NON CORE | Summary: Akt1 promotes cell growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls cell growth. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:15712201 dAkt kinase controls follicle cell size during Drosophila oogenesis. |
| GO:0035556 intracellular signal transduction | IGI PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates bot... | KEEP AS NON CORE | Summary: Akt1 participates in intracellular signal transduction. Reason: Akt1 is a core kinase in insulin/PI3K signaling. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway PMID:10962553 The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. |
| GO:0046622 positive regulation of organ growth | IMP PMID:10587646 Cell-autonomous regulation of cell and organ growth in Droso... | KEEP AS NON CORE | Summary: Akt1 promotes organ growth downstream of insulin signaling. Reason: Insulin receptor signaling regulated by Akt1 controls organ size. Supporting Evidence: file:genes/DROME/Akt1/Akt1-uniprot.txt insulin receptor transduction pathway which regulates cell growth and organ size PMID:10587646 Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. |
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