CG14662

UniProt ID: Q9VN74
Organism: Drosophila melanogaster
Review Status: DRAFT
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Gene Description

CG14662 is a 550-residue leucine-rich-repeat protein with two predicted hydrophobic membrane-spanning segments. It is a plausible membrane interaction protein, while ligand recognition, membrane topology, and physiological function remain unresolved.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0003674 molecular_function
ND
GO_REF:0000015 		ACCEPT
Summary: Molecular activity remains unknown.
Reason: A leucine-rich-repeat scaffold can mediate many interactions and does not establish a specific receptor or ligand-binding activity.
Supporting Evidence:
file:DROME/CG14662/CG14662-uniprot.txt
DR InterPro; IPR032675; LRR_dom_sf.
file:DROME/CG14662/CG14662-uniprot.txt
FT TRANSMEM 29..50 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius"
file:DROME/CG14662/CG14662-uniprot.txt
FT TRANSMEM 421..447 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius"
GO:0005575 cellular_component
ND
GO_REF:0000015 		UNDECIDED
Summary: Membrane residence is plausible but not experimentally established.
Reason: Two Phobius hydrophobic segments at residues 29-50 and 421-447 suggest membrane insertion. The source GOA unknown-component placeholder and sequence-level inference do not resolve localization or topology experimentally.
Supporting Evidence:
file:DROME/CG14662/CG14662-uniprot.txt
DR InterPro; IPR032675; LRR_dom_sf.
file:DROME/CG14662/CG14662-uniprot.txt
FT TRANSMEM 29..50 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius"
file:DROME/CG14662/CG14662-uniprot.txt
FT TRANSMEM 421..447 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius"
GO:0008150 biological_process
ND
GO_REF:0000015 		ACCEPT
Summary: Biological process remains unknown.
Reason: Neither an LRR domain nor membrane-spanning architecture identifies the pathway in which this protein acts.
Supporting Evidence:
file:DROME/CG14662/CG14662-uniprot.txt
DR InterPro; IPR032675; LRR_dom_sf.
file:DROME/CG14662/CG14662-uniprot.txt
FT TRANSMEM 29..50 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius"
file:DROME/CG14662/CG14662-uniprot.txt
FT TRANSMEM 421..447 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius"

References

GO_REF:0000015
Use of the ND evidence code for Gene Ontology (GO) terms
file:DROME/CG14662/CG14662-uniprot.txt
DROME/CG14662/CG14662-uniprot.txt

Deep Research

Falcon

(CG14662-deep-research-falcon.md)

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📚 Additional Documentation

Notes

(CG14662-notes.md)

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