id: Q8IMT2
gene_symbol: CG31099
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Phosphorylation is plausible for this EcKL/CHK-kinase-like protein, but the available family
  study proposes rather than demonstrates the relevant reactions across this diverse family.
source_documents:
- genes/DROME/CG31099/CG31099-predictions-source.json
- genes/DROME/CG31099/CG31099-uniprot-source.json
references:
- id: PMID:32540344
  title: Genomic and transcriptomic analyses in Drosophila suggest that the ecdysteroid kinase-like (EcKL)
    gene family encodes the 'detoxification-by-phosphorylation' enzymes of insects.
  findings: []
  full_text_unavailable: true
- id: file:DROME/CG31099/CG31099-uniprot.txt
  title: DROME/CG31099/CG31099-uniprot.txt
  findings: []
- id: PMID:38291829
  title: Phylogenomics of the Ecdysteroid Kinase-like (EcKL) Gene Family in Insects Highlights Roles in
    Both Steroid Hormone Metabolism and Detoxification.
  full_text_unavailable: false
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/CG31099/CG31099-predictions-source.json
  predicted_term:
    id: GO:0016310
    label: phosphorylation
  predicted_term_type: GO_BP
  review:
    assessment: UNC
    confidence_score: 1
    summary: Phosphorylation is plausible for this EcKL/CHK-kinase-like protein, but the available family
      study proposes rather than demonstrates the relevant reactions across this diverse family. No CG31099
      substrate, product or catalytic assay is established in the accessible evidence, and the existing
      ecdysteroid 22-kinase TAS annotation is itself unresolved. Domain nomenclature and agreement with
      that annotation therefore cannot independently validate the process, although there is no evidence
      refuting it.
    supported_by:
    - reference_id: PMID:32540344
      supporting_text: We propose the hypothesis that members of the arthropod-specific ecdysteroid kinase-like
        (EcKL) gene family encode detoxicative kinases.
    - reference_id: file:DROME/CG31099/CG31099-uniprot.txt
      supporting_text: /note="CHK kinase-like"
    - reference_id: PMID:38291829
      supporting_text: Our results show the only two genes known to encode ecdysteroid kinases belong
        to different subfamilies and therefore ecdysteroid metabolism functions must be spread throughout
        the EcKL family.