id: Q8IPG8
gene_symbol: CG31606
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: Secretion is supported by sequence topology; lipid transport, lipid binding and lipoprotein
  metabolism remain unresolved.
source_documents:
- genes/DROME/CG31606/CG31606-predictions-source.json
- genes/DROME/CG31606/CG31606-uniprot-source.json
references:
- id: file:DROME/CG31606/CG31606-bioinformatics/RESULTS.md
  title: DROME/CG31606/CG31606-bioinformatics/RESULTS.md
  findings: []
- id: file:DROME/CG31606/CG31606-uniprot.txt
  title: DROME/CG31606/CG31606-uniprot.txt
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/CG31606/CG31606-predictions-source.json
  predicted_term:
    id: GO:0006869
    label: lipid transport
  predicted_term_type: GO_BP
  review:
    assessment: UNC
    confidence_score: 1
    summary: Lipid transport is not established for CG31606. The raw structural donor is mammalian apolipoprotein
      A-V, but the strongly asymmetric TM scores do not establish target orthology or a conserved lipid-carrying
      mechanism. A signal peptide supports secretion rather than cargo specificity. Target lipid transport
      or convincing subfamily evidence is missing, and the claim is neither validated nor refuted.
    supported_by:
    - &id001
      reference_id: file:DROME/CG31606/CG31606-uniprot.txt
      supporting_text: SIGNAL          1..18
    - &id002
      reference_id: file:DROME/CG31606/CG31606-bioinformatics/RESULTS.md
      supporting_text: The lipid-function donor P0DTS2 is a 367-residue northern elephant seal apolipoprotein
        A-V. The two supplied TM scores are 0.50614 and 0.30402.
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/CG31606/CG31606-predictions-source.json
  predicted_term:
    id: GO:0005576
    label: extracellular region
  predicted_term_type: GO_CC
  review:
    assessment: COR
    confidence_score: 2
    summary: Extracellular localization is a reasonable inference from the cleavable N-terminal signal
      peptide and soluble mature sequence lacking a membrane anchor or canonical ER-retention terminus.
      It is not an experimentally measured compartment, and the bacterial IpgD donor is not its biological
      justification. This broad localization is absent from the ND-only GOA record, so it is a supported
      novel sequence-based prediction. It does not establish extracellular-matrix residence or lipid handling.
    supported_by:
    - *id001
    - reference_id: file:DROME/CG31606/CG31606-bioinformatics/RESULTS.md
      supporting_text: The C-terminal sequence is EEIASRILALKDNYQCA, without a hydrophobic anchor or canonical
        KDEL/HDEL retention terminus.
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/CG31606/CG31606-predictions-source.json
  predicted_term:
    id: GO:0008289
    label: lipid binding
  predicted_term_type: GO_MF
  review:
    assessment: UNC
    confidence_score: 1
    summary: No lipid-binding assay or defensible apolipoprotein subfamily placement is available for
      CG31606. The partial structural match to seal apolipoprotein A-V is a hypothesis lead rather than
      conserved ligand-binding evidence. Secretion does not identify a ligand. The exact binding claim
      remains unresolved.
    supported_by:
    - *id002
    - *id001
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  source_reference_id: file:DROME/CG31606/CG31606-predictions-source.json
  predicted_term:
    id: GO:0042157
    label: lipoprotein metabolic process
  predicted_term_type: GO_BP
  review:
    assessment: UNC
    confidence_score: 1
    summary: No evidence connects CG31606 to lipoprotein metabolism. The structurally matched apolipoprotein
      donor is not established as an ortholog, and a predicted signal peptide does not identify a pathway.
      Target perturbation, biochemical context or sound comparative functional transfer is needed to evaluate
      this process.
    supported_by:
    - *id002
    - *id001