CG32354 is a 662-residue protein with seven Kazal-like domains and a predicted N-terminal membrane-spanning segment. It is compatible with an extracellular or cell-surface interaction protein; intrinsic protease-inhibitor activity, soluble secretion, and the precise developmental role remain unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004867 serine-type endopeptidase inhibitor activity | IEA GO_REF:0000104 | UNDECIDED | Summary: Kazal-domain presence does not alone establish enzyme inhibition. Reason: Repeated Kazal-like domains support a protease-interaction hypothesis, but the exact inhibitory loops and target protease have not been functionally resolved. This fold also occurs in non-inhibitory extracellular proteins. Supporting Evidence: file:DROME/CG32354/CG32354-uniprot.txt DR InterPro; IPR002350; Kazal_dom. file:DROME/CG32354/CG32354-uniprot.txt DR InterPro; IPR036058; Kazal_dom_sf. file:DROME/CG32354/CG32354-uniprot.txt FT TRANSMEM 57..78 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG32354/CG32354-uniprot.txt FT DOMAIN 158..214 FT /note="Kazal-like" FT /evidence="ECO:0000259|PROSITE:PS51465" |
| GO:0005576 extracellular region | IBA GO_REF:0000033 | ACCEPT | Summary: An extracellular region or ectodomain is compatible with the architecture. Reason: Seven Kazal-like domains and an N-terminal hydrophobic segment support the existing curated IBA extracellular localization. This does not imply release as a soluble secreted protein. Supporting Evidence: file:DROME/CG32354/CG32354-uniprot.txt DR InterPro; IPR002350; Kazal_dom. file:DROME/CG32354/CG32354-uniprot.txt DR InterPro; IPR036058; Kazal_dom_sf. file:DROME/CG32354/CG32354-uniprot.txt FT TRANSMEM 57..78 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG32354/CG32354-uniprot.txt FT DOMAIN 158..214 FT /note="Kazal-like" FT /evidence="ECO:0000259|PROSITE:PS51465" |
| GO:0030154 cell differentiation | IBA GO_REF:0000033 | UNDECIDED | Summary: The specific differentiation role remains unresolved. Reason: Extracellular Kazal-domain proteins can have regulatory or structural functions; family architecture does not establish which differentiation process this fly protein participates in. The ancestral assertion and target function need resolution. Supporting Evidence: file:DROME/CG32354/CG32354-uniprot.txt DR InterPro; IPR002350; Kazal_dom. file:DROME/CG32354/CG32354-uniprot.txt DR InterPro; IPR036058; Kazal_dom_sf. file:DROME/CG32354/CG32354-uniprot.txt FT TRANSMEM 57..78 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG32354/CG32354-uniprot.txt FT DOMAIN 158..214 FT /note="Kazal-like" FT /evidence="ECO:0000259|PROSITE:PS51465" |
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