id: Q8IRM9
gene_symbol: CG32706
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: 'The ProtNLM2 API snapshot retrieved 2026-09-08 contains no GO-term predictions for Q8IRM9.
  RNA binding (GO:0003723) and small-subunit processome assembly (GO:0034462) are supported omission candidates:
  the target has the specific ABT1/Esf2 family assignment and retained RNA-recognition motif, existing
  PAINT/IBA annotations, and a characterized yeast Esf2 homolog that binds pre-rRNA and supports processome
  assembly. This is a conserved family inference, not a direct fly biochemical assay. The separate FUNCTION
  paragraph has CNN judgments for the broad processome/18S-rRNA claims and UNC for the exact yeast-named
  A0/A1/A2 cleavage-site requirements. No intrinsic nuclease activity is inferred. This completed record
  assesses the absence of GO output; predictions is empty because no GO or EC prediction was emitted.
  The narrative assessments remain in the linked function review and are not scores assigned to the omission.'
source_documents:
- genes/DROME/CG32706/CG32706-predictions-source.json
- projects/PROTNLM_EVALUATION/fly-benchmark/manifest.json
- genes/DROME/CG32706/CG32706-protnlm-function-review.md
- genes/DROME/CG32706/CG32706-uniprot.txt
- publications/PMID_15964808.md
references:
- id: file:DROME/CG32706/CG32706-uniprot.txt
  title: CG32706 UniProt sequence, family and annotation record
  findings:
  - statement: The target has an ABT1/Esf2 family assignment.
    supporting_text: DR   InterPro; IPR039119; ABT1/Esf2.
  - statement: Existing PAINT/IBA annotations represent RNA binding and processome assembly.
    supporting_text: DR   GO; GO:0034462; P:small-subunit processome assembly; IBA:GO_Central.
  - statement: The retained RNA-recognition motif supports an RNA-associated role.
    supporting_text: 'FT   DOMAIN          62..140

      FT                   /note="RRM"'
- id: PMID:15964808
  title: Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.
  findings:
  - statement: Yeast Esf2 associates with pre-rRNA and processome factors, supporting a conserved family
      inference rather than a direct fly experiment.
    supporting_text: 'Esf2p was stably associated with the 5''

      external transcribed spacer (ETS) and the box C+D snoRNA U3'
  - statement: Esf2 depletion impairs processome assembly.
    supporting_text: 'upon Esf2p depletion, chromatin spreads revealed that SSU processome

      assembly and compaction are inhibited'
predictions: []