id: Q9VIU4
gene_symbol: CG33116
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: All three broad predictions are supported but less precise than the ER-localized phosphatidylethanolamine-synthesis
  function.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/CG33116/CG33116-predictions-source.json
references:
- id: PMID:23449981
  title: Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine
    phosphotransferase in the Golgi lumen.
  full_text_unavailable: false
  findings: []
- id: file:DROME/CG33116/CG33116-uniprot.txt
  title: DROME/CG33116/CG33116-uniprot.txt
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0016780
    label: phosphotransferase activity, for other substituted phosphate groups
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: The phosphotransferase prediction agrees with CG33116 membership in the choline/ethanolamine
      phosphotransferase subfamily established in a primary comparative study. The PAINT assignment of
      ethanolaminephosphotransferase activity is more specific and is a reasonable conserved-reaction
      inference for this ER protein. The exact substrate activity has not been directly measured in the
      cited localization study.
    supported_by:
    - &id002
      reference_id: PMID:23449981
      supporting_text: three proteins from the CEPT subfamily (dCCS1/CG33116, dCCS2/CG6016 and dCCS3/CG7149)
    - &id001
      reference_id: PMID:23449981
      supporting_text: Both dCCS1-V5 and dCCS2-V5 localized exclusively to the ER, as evidenced by a reticular
        and nuclear envelope staining that overlapped extensively with the ER marker PE-methyltransferase
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0016020
    label: membrane
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Membrane residence is supported by the membrane phosphotransferase architecture and direct
      localization of CG33116/dCCS1 to the ER. The existing ER-membrane annotation specifies the relevant
      compartment and is more informative than membrane.
    supported_by:
    - *id001
    - reference_id: file:DROME/CG33116/CG33116-uniprot.txt
      supporting_text: DR   InterPro; IPR000462; CDP-OH_P_trans.
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0008654
    label: phospholipid biosynthetic process
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: The predicted phospholipid biosynthetic process is consistent with the conserved choline/ethanolamine
      phosphotransferase subfamily and ER localization. The curated phosphatidylethanolamine biosynthetic
      process is the supported, more specific pathway assignment. This inference concerns glycerophospholipid
      synthesis, distinct from the ceramide phosphoethanolamine synthesis experimentally assigned to CG4585.
    supported_by:
    - *id002
    - *id001