CG34117 is a small animal FMC1-family protein inferred to participate in mitochondrial ATP-synthase assembly. The characterized yeast Fmc1 comparison acts in the mitochondrial matrix to support F1 assembly or stability, particularly under heat stress. The fly protein is an assembly-factor homolog rather than an ATP-synthase catalytic subunit; target-specific localization and assembly assays remain unavailable.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0003674 molecular_function | ND GO_REF:0000015 | ACCEPT | Summary: No specific enzymatic molecular function is assigned to the assembly-factor homolog. Reason: FMC1 supports ATP-synthase assembly and is not itself an ATP-producing catalytic subunit. Retaining an unspecified molecular-function annotation is compatible with a supported assembly-factor process. Supporting Evidence: PMID:11096112 required at elevated temperatures (37 degrees C) for the formation/stability of the F(1) sector of the mitochondrial ATP synthase. |
| GO:0005739 mitochondrion | IBA GO_REF:0000033 | ACCEPT | Summary: Mitochondrial residence is supported by the FMC1 ortholog inference. Reason: The compact animal FMC1 classification and curated phylogenetic placement are consistent with experimentally characterized mitochondrial Fmc1. This is comparative support; a fly localization assay is not claimed. Supporting Evidence: file:DROME/CG34117/CG34117-uniprot.txt DR PANTHER; PTHR31716; PROTEIN FMC1 HOMOLOG; 1. PMID:11096112 Fmc1p is a soluble protein located in the mitochondrial matrix. |
| GO:0005759 mitochondrial matrix | ISS GO_REF:0000024 | ACCEPT | Summary: Matrix localization fits an F1 assembly-factor role. Reason: The experimentally characterized yeast comparison is a soluble matrix protein. The animal FMC1 homology and curated ISS assignment support the matrix location while retaining its inferential provenance. Supporting Evidence: file:DROME/CG34117/CG34117-uniprot.txt DR PANTHER; PTHR31716; PROTEIN FMC1 HOMOLOG; 1. PMID:11096112 Fmc1p is a soluble protein located in the mitochondrial matrix. |
| GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly | IBA GO_REF:0000033 | ACCEPT | Summary: ATP-synthase assembly is a defensible inherited process. Reason: FMC1 comparison connects this short protein to assembly/stability of the F1 sector. The PAINT and ISS annotations are retained as an evolutionary inference; yeast temperature dependence and intrinsic ATP-synthesis activity are not transferred to fly. Supporting Evidence: PMID:11096112 required at elevated temperatures (37 degrees C) for the formation/stability of the F(1) sector of the mitochondrial ATP synthase. file:DROME/CG34117/CG34117-uniprot.txt DR PANTHER; PTHR31716; PROTEIN FMC1 HOMOLOG; 1. |
| GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly | ISS GO_REF:0000024 | ACCEPT | Summary: ATP-synthase assembly is a defensible inherited process. Reason: FMC1 comparison connects this short protein to assembly/stability of the F1 sector. The PAINT and ISS annotations are retained as an evolutionary inference; yeast temperature dependence and intrinsic ATP-synthesis activity are not transferred to fly. Supporting Evidence: PMID:11096112 required at elevated temperatures (37 degrees C) for the formation/stability of the F(1) sector of the mitochondrial ATP synthase. file:DROME/CG34117/CG34117-uniprot.txt DR PANTHER; PTHR31716; PROTEIN FMC1 HOMOLOG; 1. |
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