id: Q9VQD1
gene_symbol: CG3515
taxon:
  id: NCBITaxon:7227
  label: Drosophila melanogaster
status: COMPLETE
description: The nucleus prediction is supported as a conserved WDR82-family localization and is already
  represented in the annotation record.
source_documents:
- projects/PROTNLM_EVALUATION/fly-benchmark/predictions.jsonl.gz
- genes/DROME/CG3515/CG3515-predictions-source.json
references:
- id: file:DROME/CG3515/CG3515-uniprot.txt
  title: DROME/CG3515/CG3515-uniprot.txt
  findings: []
- id: PMID:18838538
  title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
  full_text_unavailable: true
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0005634
    label: nucleus
  predicted_term_type: GO_CC
  review:
    assessment: CNN
    confidence_score: 2
    summary: Nuclear localization is a reasonable conserved inference from the diagnostic Swd2/WDR82 family
      assignment and curated chromatin/COMPASS placement. Primary WDR82 experiments establish chromatin
      association and Set1-complex membership, providing the biological basis for that transfer. CG3515
      is a separate fly paralog from Wdr82/CG17293, so these are not claimed as direct target experiments.
      The nucleus term is already present, making this supported prediction non-novel.
    supported_by:
    - reference_id: file:DROME/CG3515/CG3515-uniprot.txt
      supporting_text: DR   InterPro; IPR037867; Swd2/WDR82.
    - reference_id: PMID:18838538
      supporting_text: 'We have shown that Wdr82,

        which associates with chromatin in a histone H2B ubiquitination-dependent

        manner, is a specific component of Set1 complexes but not that of MLL1-4

        complexes.'