CG42404 is a 1133-residue VWFC-domain protein with a predicted membrane-spanning segment near its N terminus. Its extracellular-domain-like architecture and membrane association are compatible with a cell-surface interaction protein, but ligand specificity, topology, and biological activity are unresolved.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0003674 molecular_function | ND GO_REF:0000015 | ACCEPT | Summary: Molecular activity remains unknown. Reason: A VWFC domain does not specify a ligand or a receptor activity for this fly product. Supporting Evidence: file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR042378; IDD. file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR001007; VWF_dom. file:DROME/CG42404/CG42404-uniprot.txt FT TRANSMEM 103..125 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG42404/CG42404-uniprot.txt FT DOMAIN 27..92 FT /note="VWFC" FT /evidence="ECO:0000259|PROSITE:PS50184" |
| GO:0005575 cellular_component | ND GO_REF:0000015 | MODIFY | Summary: Membrane localization is supported more specifically than the unknown-component placeholder. Reason: The exact record carries a Phobius transmembrane segment at residues 103-125 and a curated IBA membrane annotation. The broad membrane term is supported without identifying a particular organelle. Proposed replacements: membrane Supporting Evidence: file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR042378; IDD. file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR001007; VWF_dom. file:DROME/CG42404/CG42404-uniprot.txt FT TRANSMEM 103..125 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG42404/CG42404-uniprot.txt FT DOMAIN 27..92 FT /note="VWFC" FT /evidence="ECO:0000259|PROSITE:PS50184" |
| GO:0008150 biological_process | ND GO_REF:0000015 | ACCEPT | Summary: Biological process remains unknown. Reason: Domain and topology evidence do not establish a developmental or signaling pathway. Supporting Evidence: file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR042378; IDD. file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR001007; VWF_dom. file:DROME/CG42404/CG42404-uniprot.txt FT TRANSMEM 103..125 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG42404/CG42404-uniprot.txt FT DOMAIN 27..92 FT /note="VWFC" FT /evidence="ECO:0000259|PROSITE:PS50184" |
| GO:0016020 membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Membrane association is supported. Reason: A predicted membrane-spanning segment at residues 103-125 is consistent with the existing phylogenetically curated membrane annotation; specific topology and tissue function are unresolved. Supporting Evidence: file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR042378; IDD. file:DROME/CG42404/CG42404-uniprot.txt DR InterPro; IPR001007; VWF_dom. file:DROME/CG42404/CG42404-uniprot.txt FT TRANSMEM 103..125 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" file:DROME/CG42404/CG42404-uniprot.txt FT DOMAIN 27..92 FT /note="VWFC" FT /evidence="ECO:0000259|PROSITE:PS50184" |
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